Search Results - "Grocott, Michael PW"

Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial by McAuley, Daniel F, Prof, Cross, LJ Mark, PhD, Hamid, Umar, MD, Gardner, Evie, MSc, Elborn, J Stuart, Prof, Cullen, Kathy M, PhD, Dushianthan, Ahilanandan, PhD, Grocott, Michael PW, Prof, Matthay, Michael A, Prof, O'Kane, Cecilia M, PhD

“…Summary Background Data from in-vitro, animal, and human lung injury models suggest that keratinocyte growth factor (KGF) might be beneficial in acute…”
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Exercise rehabilitation following intensive care unit discharge for recovery from critical illness by Connolly, Bronwen, Salisbury, Lisa, O'Neill, Brenda, Geneen, Louise, Douiri, Abdel, Grocott, Michael P W, Hart, Nicholas, Walsh, Timothy S, Blackwood, Bronagh

“…Skeletal muscle wasting and weakness are significant complications of critical illness, associated with degree of illness severity and periods of reduced…”
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Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery by Grocott, Michael P W, Dushianthan, Ahilanandan, Hamilton, Mark A, Mythen, Michael G, Harrison, David, Rowan, Kathy

“…Studies have suggested that increasing whole body blood flow and oxygen delivery around the time of surgery reduces mortality, morbidity and the expense of…”
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The physiological effects of hypobaric hypoxia versus normobaric hypoxia: a systematic review of crossover trials by Coppel, Jonny, Hennis, Philip, Gilbert-Kawai, Edward, Grocott, Michael Pw

“…Much hypoxia research has been carried out at high altitude in a hypobaric hypoxia (HH) environment. Many research teams seek to replicate high-altitude…”
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Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia by Levett, Denny Z H, Martin, Daniel S, Wilson, Mark H, Mitchell, Kay, Dhillon, Sundeep, Rigat, Fabio, Montgomery, Hugh E, Mythen, Monty G, Grocott, Michael P W

“…The physiological responses to hypoxaemia and cellular hypoxia are poorly understood, and inter-individual differences in performance at altitude and outcome…”
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Goal-directed haemodynamic therapy (GDHT) in surgical patients: systematic review and meta-analysis of the impact of GDHT on post-operative pulmonary complications by Dushianthan, Ahilanandan, Knight, Martin, Russell, Peter, Grocott, Michael Pw

“…Perioperative goal-directed haemodynamic therapy (GDHT), defined as the administration of fluids with or without inotropes or vasoactive agents against…”
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Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients by Gilbert-Kawai, Edward T, Mitchell, Kay, Martin, Daniel, Carlisle, John, Grocott, Michael P W

“…Permissive hypoxaemia describes a concept in which a lower level of arterial oxygenation (PaO2) than usual is accepted to avoid the detrimental effects of high…”
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Immunonutrition for acute respiratory distress syndrome (ARDS) in adults by Dushianthan, Ahilanandan, Cusack, Rebecca, Burgess, Victoria A, Grocott, Michael Pw, Calder, Philip C

“…Acute respiratory distress syndrome (ARDS) is an overwhelming systemic inflammatory process associated with significant morbidity and mortality…”
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Eye movement desensitisation and reprocessing for survivors of life-threatening medical events by Bates, Andrew, Baldwin, David S, Pattison, Natalie, Moyses, Helen, Huneke, Nathan Tm, Cortese, Samuele, Grocott, Michael Pw, Cusack, Rebecca

“…This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of eye movement desensitisation and reprocessing…”
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Mt Everest trek causes impaired cardiac high energy phosphate metabolism and diastolic impairment by Holloway, Cameorn J, Murray, Andrew, Cochlin, Lowri E, Emmanuel, Yaso, Levett, Denny ZH, Rider, Oliver J, Tyler, Damian J, Robson, Matthew, Francis, Jane M, Montgomery, Hugh, Grocott, Michael PW, Neubauer, Stefan, Clarke, Kieran

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King of the mountains: Tibetan and Sherpa physiological adaptations for life at high altitude by Gilbert-Kawai, Edward T, Milledge, James S, Grocott, Michael P W, Martin, Daniel S

“…Anecdotal evidence surrounding Tibetans' and Sherpas' exceptional tolerance to hypobaric hypoxia has been recorded since the beginning of high-altitude…”
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Arterial Blood Gases and Oxygen Content in Climbers on Mount Everest by Grocott, Michael P.W, Martin, Daniel S, Levett, Denny Z.H, McMorrow, Roger, Windsor, Jeremy, Montgomery, Hugh E

“…Ambient oxygen tension falls with decreasing barometric pressure, limiting the ability of oxygen to diffuse into the blood. In this field study, the authors…”
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Immunonutrition for Adults With ARDS: Results From a Cochrane Systematic Review and Meta-Analysis by Dushianthan, Ahilanandan, Cusack, Rebecca, Burgess, Victoria A, Grocott, Michael Pw, Calder, Philip

“…ARDS is an overwhelming systemic inflammatory process associated with significant morbidity and mortality. Several trials have evaluated the effects of…”
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Exercise interventions for people undergoing multimodal cancer treatment that includes surgery by Loughney, Lisa A, West, Malcolm A, Kemp, Graham J, Grocott, Michael Pw, Jack, Sandy

“…People undergoing multimodal cancer treatment are at an increased risk of adverse events. Physical fitness significantly reduces following cancer treatment,…”
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Oxygen targets in the intensive care unit during mechanical ventilation for acute respiratory distress syndrome: a rapid review by Cumpstey, Andrew F, Oldman, Alex H, Smith, Andrew F, Martin, Daniel, Grocott, Michael Pw

“…Supplemental oxygen is frequently administered to patients with acute respiratory distress syndrome (ARDS), including ARDS secondary to viral illness such as…”
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Pathway redesign: putting patients ahead of professionals by Grocott, Michael PW

“…Many perioperative clinical pathways, and therefore patient journeys, are focused around provider, rather than patient, convenience. Business process…”
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Perioperative administration of buffered versus non-buffered crystalloid intravenous fluid to improve outcomes following adult surgical procedures by Bampoe, Sohail, Odor, Peter M, Dushianthan, Ahilanandan, Bennett-Guerrero, Elliott, Cro, Suzie, Gan, Tong J, Grocott, Michael Pw, James, Michael Fm, Mythen, Michael G, O'Malley, Catherine Mn, Roche, Anthony M, Rowan, Kathy, Burdett, Edward

“…Perioperative fluid strategies influence clinical outcomes following major surgery. Many intravenous fluid preparations are based on simple solutions, such as…”
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Cardiopulmonary exercise testing has greater prognostic value than sarcopenia in oesophago‐gastric cancer patients undergoing neoadjuvant therapy and surgical resection by West, Malcolm A, Baker, William CA, Rahman, Saqib, Munro, Alicia, Jack, Sandy, Grocott, Michael PW, Underwood, Timothy J, Levett, Denny ZH

“…Background Sarcopenia (low skeletal muscle mass), myosteatosis (low skeletal muscle radiation‐attenuation) and fitness are independently associated with…”
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The effects of exercise on pain, fatigue, insomnia, and health perceptions in patients with operable advanced stage rectal cancer prior to surgery: a pilot trial by Brunet, Jennifer, Burke, Shaunna, Grocott, Michael P W, West, Malcolm A, Jack, Sandy

“…Promoting quality of life (QoL) is a key priority in cancer care. We investigated the hypothesis that, in comparison to usual care, exercise post-neoadjuvant…”
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High sensitivity troponin measurement in critical care: Flattering to deceive or ‘never means nothing’? by Hinton, Jonathan, Mariathas, Mark, Grocott, Michael PW, Curzen, Nick

“…Introduction Troponin elevation is central to the diagnosis of acute type 1 myocardial infarction. It is, however, elevated in a range of other conditions,…”
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