Search Results - "Grötzinger, Joachim"

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation by Riethmueller, Steffen, Somasundaram, Prasath, Ehlers, Johanna C, Hung, Chien-Wen, Flynn, Charlotte M, Lokau, Juliane, Agthe, Maria, Düsterhöft, Stefan, Zhu, Yijue, Grötzinger, Joachim, Lorenzen, Inken, Koudelka, Tomas, Yamamoto, Kosuke, Pickhinke, Ute, Wichert, Rielana, Becker-Pauly, Christoph, Rädisch, Marisa, Albrecht, Alexander, Hessefort, Markus, Stahnke, Dominik, Unverzagt, Carlo, Rose-John, Stefan, Tholey, Andreas, Garbers, Christoph

“…Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes…”
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Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes by Groth, Esther, Pruessmeyer, Jessica, Babendreyer, Aaron, Schumacher, Julian, Pasqualon, Tobias, Dreymueller, Daniela, Higashiyama, Shigeki, Lorenzen, Inken, Grötzinger, Joachim, Cataldo, Didier, Ludwig, Andreas

“…By mediating proteolytic shedding on the cell surface the disintegrin and metalloproteinases ADAM10 and ADAM17 function as critical regulators of growth…”
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The Nucleotide-Binding Oligomerization Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses by Kuenzel, Sven, Till, Andreas, Winkler, Michael, Hasler, Robert, Lipinski, Simone, Jung, Sascha, Grotzinger, Joachim, Fickenscher, Helmut, Schreiber, Stefan, Rosenstiel, Philip

“…Nucleotide-binding oligomerization domain-like receptors (NLRs) are a group of intracellular proteins that mediate recognition of pathogen-associated molecular…”
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Plasticity and cross-talk of Interleukin 6-type cytokines by Garbers, Christoph, Hermanns, Heike M, Schaper, Fred, Müller-Newen, Gerhard, Grötzinger, Joachim, Rose-John, Stefan, Scheller, Jürgen

“…Abstract Interleukin (IL)-6-type cytokines are critically involved in health and disease. The duration and strength of IL-6-type cytokine-mediated signaling is…”
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Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide by Hein, Kyaw Zaw, Takahashi, Hitoshi, Tsumori, Toshiko, Yasui, Yukihiko, Nanjoh, Yasuko, Toga, Tetsuo, Wu, Zhihong, Grötzinger, Joachim, Jung, Sascha, Wehkamp, Jan, Schroeder, Bjoern O., Schroeder, Jens M., Morita, Eishin

“…The unexpected resistance of psoriasis lesions to fungal infections suggests local production of an antifungal factor. We purifiedTrichophyton…”
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Phosphatidylserine exposure is required for ADAM17 sheddase function by Sommer, Anselm, Kordowski, Felix, Büch, Joscha, Maretzky, Thorsten, Evers, Astrid, Andrä, Jörg, Düsterhöft, Stefan, Michalek, Matthias, Lorenzen, Inken, Somasundaram, Prasath, Tholey, Andreas, Sönnichsen, Frank D., Kunzelmann, Karl, Heinbockel, Lena, Nehls, Christian, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit, Reiss, Karina

“…ADAM17, a prominent member of the ‘Disintegrin and Metalloproteinase’ (ADAM) family, controls vital cellular functions through cleavage of transmembrane…”
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Membrane-Proximal Domain of a Disintegrin and Metalloprotease-17 Represents the Putative Molecular Switch of Its Shedding Activity Operated by Protein-disulfide Isomerase by Düsterhöft, Stefan, Jung, Sascha, Hung, Chien-Wen, Tholey, Andreas, Sönnichsen, Frank D, Grötzinger, Joachim, Lorenzen, Inken

“…A disintegrin and metalloprotease-17 (ADAM17) is a major sheddase responsible for the regulation of a wide range of biological processes, like cellular…”
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A secreted antibacterial neuropeptide shapes the microbiome of Hydra by Augustin, René, Schröder, Katja, Murillo Rincón, Andrea P., Fraune, Sebastian, Anton-Erxleben, Friederike, Herbst, Eva-Maria, Wittlieb, Jörg, Schwentner, Martin, Grötzinger, Joachim, Wassenaar, Trudy M., Bosch, Thomas C. G.

“…Colonization of body epithelial surfaces with a highly specific microbial community is a fundamental feature of all animals, yet the underlying mechanisms by…”
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Molecular Determinants of KCNQ (Kv7) K+ Channel Sensitivity to the Anticonvulsant Retigabine by Schenzer, Anne, Friedrich, Thomas, Pusch, Michael, Saftig, Paul, Jentsch, Thomas J, Grotzinger, Joachim, Schwake, Michael

“…Epilepsy is caused by an electrical hyperexcitability in the CNS. Because K+ channels are critical for establishing and stabilizing the resting potential of…”
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Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity by Düsterhöft, Stefan, Michalek, Matthias, Kordowski, Felix, Oldefest, Mirja, Sommer, Anselm, Röseler, Jona, Reiss, Karina, Grötzinger, Joachim, Lorenzen, Inken

“…A wide variety of biological processes including differentiation, regeneration, and cancer progression are regulated by shedding of membrane-anchored proteins…”
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Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17 by Riethmueller, Steffen, Ehlers, Johanna C., Lokau, Juliane, Düsterhöft, Stefan, Knittler, Katharina, Dombrowsky, Gregor, Grötzinger, Joachim, Rabe, Björn, Rose-John, Stefan, Garbers, Christoph

“…Limited proteolysis of the Interleukin-6 Receptor (IL-6R) leads to the release of the IL-6R ectodomain. Binding of the cytokine IL-6 to the soluble IL-6R…”
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The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II by Lorenzen, Inken, Lokau, Juliane, Düsterhöft, Stefan, Trad, Ahmad, Garbers, Christoph, Scheller, Jürgen, Rose-John, Stefan, Grötzinger, Joachim

“…► The transmembrane protease ADAM17 recognizes more than 70 substrates. ► The minimal requirement for recognition of two substrates was identified. ► The…”
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Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells by Lokau, Juliane, Kleinegger, Florian, Garbers, Yvonne, Waetzig, Georg H, Grötzinger, Joachim, Rose-John, Stefan, Haybaeck, Johannes, Garbers, Christoph

“…Tocilizumab is a humanized monoclonal antibody that is approved for the treatment of different human inflammatory diseases, including rheumatoid arthritis and…”
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A role for IL-27p28 as an antagonist of gp130-mediated signaling by Hunter, Christopher A, Stumhofer, Jason S, Tait, Elia D, III, William J Quinn, Hosken, Nancy, Spudy, Björn, Goenka, Radhika, Fielding, Ceri A, O'Hara, Aisling C, Chen, Yi, Jones, Michael L, Saris, Christiaan J M, Rose-John, Stefan, Cua, Daniel J, Jones, Simon A, Elloso, Merle M, Grötzinger, Joachim, Cancro, Michael P, Levin, Steven D

“…The heterodimeric cytokine IL-27 consists of the subunits p28 and EBI3. Hunter and colleagues demonstrate that p28 acting alone can inhibit the signaling of…”
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ADAM10 sheddase activation is controlled by cell membrane asymmetry by Bleibaum, Florian, Sommer, Anselm, Veit, Martin, Rabe, Björn, Andrä, Jörg, Kunzelmann, Karl, Nehls, Christian, Correa, Wilmar, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit, Reiss, Karina

“…Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer's disease. The…”
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An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer by Garbers, Christoph, Spudy, Björn, Aparicio-Siegmund, Samadhi, Waetzig, Georg H., Sommer, Jan, Hölscher, Christoph, Rose-John, Stefan, Grötzinger, Joachim, Lorenzen, Inken, Scheller, Jürgen

“…IL-27 consists of the cytokine subunit p28 and the non-signaling α-receptor EBI3. p28 was shown to additionally act via the non-signaling membrane-bound IL-6…”
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Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice by Roderfeld, Martin, Weiskirchen, Ralf, Wagner, Sandra, Berres, Marie-Luise, Henkel, Corinna, Grötzinger, Joachim, Gressner, Axel M, Matern, Siegfried, Roeb, Elke

“…Tissue inhibitor of metalloproteinases-1 (TIMP-1) plays a crucial role in the pathogenesis of hepatic fibrosis and thus may represent an important therapeutic…”
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Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor by Garbers, Christoph, Thaiss, Wolfgang, Jones, Gareth W., Waetzig, Georg H., Lorenzen, Inken, Guilhot, Florence, Lissilaa, Rami, Ferlin, Walter G., Grötzinger, Joachim, Jones, Simon A., Rose-John, Stefan, Scheller, Jürgen

“…IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically…”
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A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor by Düsterhöft, Stefan, Höbel, Katharina, Oldefest, Mirja, Lokau, Juliane, Waetzig, Georg H., Chalaris, Athena, Garbers, Christoph, Scheller, Jürgen, Rose-John, Stefan, Lorenzen, Inken, Grötzinger, Joachim

“…A disintegrin and metalloprotease 17 (ADAM17) is a major sheddase involved in the regulation of a wide range of biological processes. Key substrates of ADAM17…”
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Two N-Linked Glycans Differentially Control Maturation, Trafficking and Proteolysis, but not Activity of the IL-11 Receptor by Agthe, Maria, Garbers, Yvonne, Grötzinger, Joachim, Garbers, Christoph

“…Background/Aims: The cytokine interleukin-11 (IL-11) has important pro- and anti-inflammatory functions. It activates its target cells through binding to the…”
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