Search Results - "Grönholm, Mikaela"

How integrin phosphorylations regulate cell adhesion and signaling by Gahmberg, Carl G., Grönholm, Mikaela

“…Cell adhesion is essential for the formation of organs, cellular migration, and interaction with target cells and the extracellular matrix. Integrins are large…”
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Patient-Derived Organoids for Precision Cancer Immunotherapy by Grönholm, Mikaela, Feodoroff, Michaela, Antignani, Gabriella, Martins, Beatriz, Hamdan, Firas, Cerullo, Vincenzo

“…Cancer immunotherapy has revolutionized the way tumors are treated. Nevertheless, efficient and robust testing platforms are still missing, including…”
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Bioadhesive supramolecular hydrogel from unprotected, short d,l-peptides with Phe-Phe and Leu-Asp-Val motifs by Cringoli, Maria Cristina, Romano, Chiara, Parisi, Evelina, Waddington, Lynne J, Melchionna, Michele, Semeraro, Sabrina, De Zorzi, Rita, Grönholm, Mikaela, Marchesan, Silvia

“…The uncapped tripeptide DPhe-Phe-Leu acts as self-assembly template to yield supramolecular hydrogel biomaterials. As an example, self-assembling…”
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Regulation of cell adhesion: a collaborative effort of integrins, their ligands, cytoplasmic actors, and phosphorylation by Gahmberg, Carl G, Grönholm, Mikaela, Madhavan, Sudarrshan, Jahan, Farhana, Mikkola, Esa, Viazmina, Larisa, Koivunen, Erkki

“…Integrins are large heterodimeric type 1 membrane proteins expressed in all nucleated mammalian cells. Eighteen α-chains and eight β-chains can combine to form…”
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Isolation and characterization of platelet-derived extracellular vesicles by Aatonen, Maria T., Öhman, Tiina, Nyman, Tuula A., Laitinen, Saara, Grönholm, Mikaela, Siljander, Pia R.-M.

“…Platelet-derived extracellular vesicles (EVs) participate, for example, in haemostasis, immunity and development. Most studies of platelet EVs have targeted…”
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Platelet-derived microvesicles: multitalented participants in intercellular communication by Aatonen, Maria, Grönholm, Mikaela, Siljander, Pia R-M

“…Platelets can release a heterogeneous pool of vesicles which include plasma membrane-derived microparticles (PMPs) and multivesicular body-derived exosomes. As…”
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Regulation of integrin activity and signalling by Gahmberg, Carl G., Fagerholm, Susanna C., Nurmi, Susanna M., Chavakis, Triantafyllos, Marchesan, Silvia, Grönholm, Mikaela

“…The ability of cells to attach to each other and to the extracellular matrix is of pivotal significance for the formation of functional organs and for the…”
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Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids by Hamdan, Firas, Ylösmäki, Erkko, Chiaro, Jacopo, Giannoula, Yvonne, Long, Maeve, Fusciello, Manlio, Feola, Sara, Martins, Beatriz, Feodoroff, Michaela, Antignani, Gabriella, Russo, Salvatore, Kari, Otto, Lee, Moon Hee, Järvinen, Petrus, Nisen, Harry, Kreutzman, Anna, Leusen, Jeanette, Mustjoki, Satu, McWilliams, Thomas G, Grönholm, Mikaela, Cerullo, Vincenzo

“…BackgroundDespite the success of immune checkpoint inhibitors against PD-L1 in the clinic, only a fraction of patients benefit from such therapy. A theoretical…”
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Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma by Chiaro, Jacopo, Kasanen, Henna H E, Whalley, Thomas, Capasso, Cristian, Grönholm, Mikaela, Feola, Sara, Peltonen, Karita, Hamdan, Firas, Hernberg, Micaela, Mäkelä, Siru, Karhapää, Hanna, Brown, Paul E, Martins, Beatriz, Fusciello, Manlio, Ylösmäki, Erkko O, Greco, Dario, Kreutzman, Anna S, Mustjoki, Satu, Szomolay, Barbara, Cerullo, Vincenzo

“…Molecular mimicry is one of the leading mechanisms by which infectious agents can induce autoimmunity. Whether a similar mechanism triggers an antitumor immune…”
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Novel peptide-based oncolytic vaccine for enhancement of adaptive antitumor immune response via co-engagement of innate Fcγ and Fcα receptors by Feola, Sara, Hamdan, Firas, Russo, Salvatore, Chiaro, Jacopo, Fusciello, Manlio, Feodoroff, Michaela, Antignani, Gabriella, D'Alessio, Federica, Mölsä, Riikka, Stigzelius, Virpi, Bottega, Paolo, Pesonen, Sari, Leusen, Jeanette, Grönholm, Mikaela, Cerullo, Vincenzo

“…BackgroundCancer immunotherapy relies on using the immune system to recognize and eradicate cancer cells. Adaptive immunity, which consists of mainly…”
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PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification by Feola, Sara, Haapala, Markus, Peltonen, Karita, Capasso, Cristian, Martins, Beatriz, Antignani, Gabriella, Federico, Antonio, Pietiäinen, Vilja, Chiaro, Jacopo, Feodoroff, Michaela, Russo, Salvatore, Rannikko, Antti, Fusciello, Manlio, Koskela, Satu, Partanen, Jukka, Hamdan, Firas, Tähkä, Sari M, Ylösmäki, Erkko, Greco, Dario, Grönholm, Mikaela, Kekarainen, Tuija, Eshaghi, Masoumeh, Gurvich, Olga L, Ylä-Herttuala, Seppo, M. Branca, Rui M, Lehtiö, Janne, Sikanen, Tiina M, Cerullo, Vincenzo

“…Identification of HLA class I ligands from the tumor surface (ligandome or immunopeptidome) is essential for designing T-cell mediated cancer therapeutic…”
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Low-dose decitabine enhances the efficacy of viral cancer vaccines for immunotherapy by Russo, Salvatore, Feola, Sara, Feodoroff, Michaela, Chiaro, Jacopo, Antignani, Gabriella, Fusciello, Manlio, D'Alessio, Federica, Hamdan, Firas, Pellinen, Teijo, Mölsä, Riikka, Tripodi, Lorella, Pastore, Lucio, Grönholm, Mikaela, Cerullo, Vincenzo

“…Cancer immunotherapy requires a specific antitumor CD8 T cell-driven immune response; however, upon genetic and epigenetic alterations of the antigen…”
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HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation by Rouhiainen, Ari, Zhao, Xiang, Vanttola, Päivi, Qian, Kui, Kulesskiy, Evgeny, Kuja-Panula, Juha, Gransalke, Kathleen, Grönholm, Mikaela, Unni, Emmanual, Meistrich, Marvin, Tian, Li, Auvinen, Petri, Rauvala, Heikki

“…HMGB4 is a new member in the family of HMGB proteins that has been characterized in sperm cells, but little is known about its functions in somatic cells. Here…”
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Regulation of Dynamic Cell Adhesion by Integrin-Integrin Crosstalk by Gahmberg, Carl G, Grönholm, Mikaela, Madhavan, Sudarrshan

“…Most cells express several integrins. The integrins are able to respond to various cellular functions and needs by modifying their own activation state, but in…”
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Controlled release of enhanced cross-hybrid IgGA Fc PD-L1 inhibitors using oncolytic adenoviruses by Hamdan, Firas, Feodoroff, Michaela, Russo, Salvatore, Fusciello, Manlio, Feola, Sara, Chiaro, Jacopo, Antignani, Gabriella, Greco, Francesca, Leusen, Jeanette, Ylösmäki, Erkko, Grönholm, Mikaela, Cerullo, Vincenzo

“…Immune checkpoint inhibitors have clinical success in prolonging the life of many cancer patients. However, only a minority of patients benefit from such…”
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GAMER-Ad: a novel and rapid method for generating recombinant adenoviruses by Hamdan, Firas, Martins, Beatriz, Feodoroff, Michaela, Giannoula, Yvonne, Feola, Sara, Fusciello, Manlio, Chiaro, Jacopo, Antignani, Gabriella, Grönholm, Mikaela, Ylösmäki, Erkko, Cerullo, Vincenzo

“…Oncolytic adenoviruses have become ideal agents in the path toward treating cancer. Such viruses have been engineered to conditionally replicate in malignant…”
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Abnormal actin binding of aberrant β-tropomyosins is a molecular cause of muscle weakness in TPM2-related nemaline and cap myopathy by Marttila, Minttu, Lemola, Elina, Wallefeld, William, Memo, Massimiliano, Donner, Kati, Laing, Nigel G, Marston, Steven, Grönholm, Mikaela, Wallgren-Pettersson, Carina

“…NM (nemaline myopathy) is a rare genetic muscle disorder defined on the basis of muscle weakness and the presence of structural abnormalities in the muscle…”
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A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines by Feola, Sara, Chiaro, Jacopo, Martins, Beatriz, Russo, Salvatore, Fusciello, Manlio, Ylösmäki, Erkko, Bonini, Chiara, Ruggiero, Eliana, Hamdan, Firas, Feodoroff, Michaela, Antignani, Gabriella, Viitala, Tapani, Pesonen, Sari, Grönholm, Mikaela, Branca, Rui M M, Lehtiö, Janne, Cerullo, Vincenzo

“…Besides the isolation and identification of major histocompatibility complex I-restricted peptides from the surface of cancer cells, one of the challenges is…”
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TCR-induced activation of LFA-1 involves signaling through Tiam1 by Grönholm, Mikaela, Jahan, Farhana, Marchesan, Silvia, Karvonen, Ulla, Aatonen, Maria, Narumanchi, Suneeta, Gahmberg, Carl G

“…Adhesion is pivotal for most leukocyte functions, and the β(2) integrin family of adhesion molecules plays a central role. The integrins need activation to…”
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Peptides-Coated Oncolytic Vaccines for Cancer Personalized Medicine by Feola, Sara, Russo, Salvatore, Martins, Beatriz, Lopes, Alessandra, Vandermeulen, Gaëlle, Fluhler, Vinciane, De Giorgi, Camilla, Fusciello, Manlio, Pesonen, Sari, Ylösmäki, Erkko, Antignani, Gabriella, Chiaro, Jacopo, Hamdan, Firas, Feodoroff, Michaela, Grönholm, Mikaela, Cerullo, Vincenzo

“…Oncolytic Viruses (OVs) work through two main mechanisms of action: the direct lysis of the virus-infected cancer cells and the release of tumor antigens as a…”
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