Search Results - "Großmann, Dajana"

Increased Vulnerability to Ferroptosis in FUS-ALS by Ismail, Muhammad, Großmann, Dajana, Hermann, Andreas

“…Ferroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxide accumulation, plays a pivotal role in various pathological…”
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The Emerging Role of RHOT1/Miro1 in the Pathogenesis of Parkinson's Disease by Grossmann, Dajana, Berenguer-Escuder, Clara, Chemla, Axel, Arena, Giuseppe, Krüger, Rejko

“…The expected increase in prevalence of Parkinson's disease (PD) as the most common neurodegenerative movement disorder over the next years underscores the need…”
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Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1 by Chemla, Axel, Arena, Giuseppe, Onal, Gizem, Walter, Jonas, Berenguer-Escuder, Clara, Grossmann, Dajana, Grünewald, Anne, Schwamborn, Jens C., Krüger, Rejko

“…Fibroblasts from two Parkinson’s disease (PD) patients carrying either the heterozygous mutation c.815G > A (Miro1 p.R272Q) or c.1348C > T (Miro1 p.R450C) in…”
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Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.1290A > G (p.T351A) or c.2067A > G (p.T610A) in the RHOT1 gene encoding Miro1 by Chemla, Axel, Arena, Giuseppe, Saraiva, Claudia, Berenguer-Escuder, Clara, Grossmann, Dajana, Grünewald, Anne, Klein, Christine, Seibler, Philip, Schwamborn, Jens C., Krüger, Rejko

“…Primary skin fibroblasts from two Parkinson’s disease (PD) patients carrying distinct heterozygous mutations in the RHOT1 gene encoding Miro1, namely…”
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Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons by Zimyanin, Vitaly L, Pielka, Anna-Maria, Glaß, Hannes, Japtok, Julia, Großmann, Dajana, Martin, Melanie, Deussen, Andreas, Szewczyk, Barbara, Deppmann, Chris, Zunder, Eli, Andersen, Peter M, Boeckers, Tobias M, Sterneckert, Jared, Redemann, Stefanie, Storch, Alexander, Hermann, Andreas

“…Motoneurons are one of the most energy-demanding cell types and a primary target in Amyotrophic lateral sclerosis (ALS), a debilitating and lethal…”
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Mitochondria interaction networks show altered topological patterns in Parkinson’s disease by Zanin, Massimiliano, Santos, Bruno F. R., Antony, Paul M. A., Berenguer-Escuder, Clara, Larsen, Simone B., Hanss, Zoé, Barbuti, Peter A., Baumuratov, Aidos S., Grossmann, Dajana, Capelle, Christophe M., Weber, Joseph, Balling, Rudi, Ollert, Markus, Krüger, Rejko, Diederich, Nico J., He, Feng Q.

“…Mitochondrial dysfunction is linked to pathogenesis of Parkinson’s disease (PD). However, individual mitochondria-based analyses do not show a uniform feature…”
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Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease by Pereira, Sandro L., Grossmann, Dajana, Delcambre, Sylvie, Hermann, Andreas, Grünewald, Anne

“…Mutations in PRKN cause the second most common genetic form of Parkinson's disease (PD)—a debilitating movement disorder that is on the rise due to population…”
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Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease by Berenguer-Escuder, Clara, Grossmann, Dajana, Antony, Paul, Arena, Giuseppe, Wasner, Kobi, Massart, François, Jarazo, Javier, Walter, Jonas, Schwamborn, Jens C, Grünewald, Anne, Krüger, Rejko

“…Abstract Mitochondrial Rho GTPase 1 (Miro1) protein is a well-known adaptor for mitochondrial transport and also regulates mitochondrial quality control and…”
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Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons by Grossmann, Dajana, Malburg, Nina, Glaß, Hannes, Weeren, Veronika, Sondermann, Verena, Pfeiffer, Julia F, Petters, Janine, Lukas, Jan, Seibler, Philip, Klein, Christine, Grünewald, Anne, Hermann, Andreas

“…It is generally believed that the pathogenesis of PINK1/parkin-related Parkinson's disease (PD) is due to a disturbance in mitochondrial quality control…”
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Polygenic Risk Scores Validated in Patient‐Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease by Arena, Giuseppe, Landoulsi, Zied, Grossmann, Dajana, Payne, Thomas, Vitali, Armelle, Delcambre, Sylvie, Baron, Alexandre, Antony, Paul, Boussaad, Ibrahim, Bobbili, Dheeraj Reddy, Sreelatha, Ashwin Ashok Kumar, Pavelka, Lukas, Diederich, Nico, Klein, Christine, Seibler, Philip, Glaab, Enrico, Foltynie, Thomas, Bandmann, Oliver, Sharma, Manu, Krüger, Rejko, May, Patrick, Grünewald, Anne

“…Objective The aim of our study is to better understand the genetic architecture and pathological mechanisms underlying neurodegeneration in idiopathic…”
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Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy by Neumann, Marie Anne-Catherine, Grossmann, Dajana, Schimpf-Linzenbold, Simone, Dayan, Dana, Stingl, Katarina, Ben-Menachem, Reut, Pines, Ophry, Massart, François, Delcambre, Sylvie, Ghelfi, Jenny, Bohler, Jill, Strom, Tim, Kessel, Amit, Azem, Abdussalam, Schöls, Ludger, Grünewald, Anne, Wissinger, Bernd, Krüger, Rejko

“…ACO2 is a mitochondrial protein, which is critically involved in the function of the tricarboxylic acid cycle (TCA), the maintenance of iron homeostasis,…”
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Variants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson's Disease Patients by Berenguer-Escuder, Clara, Grossmann, Dajana, Massart, Franҫois, Antony, Paul, Burbulla, Lena F, Glaab, Enrico, Imhoff, Sophie, Trinh, Joanne, Seibler, Philip, Grünewald, Anne, Krüger, Rejko

“…Although most cases of Parkinson´s disease (PD) are idiopathic with unknown cause, an increasing number of genes and genetic risk factors have been discovered…”
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Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS by Pal, Arun, Grossmann, Dajana, Glaß, Hannes, Zimyanin, Vitaly, Günther, René, Catinozzi, Marica, Boeckers, Tobias M, Sterneckert, Jared, Storkebaum, Erik, Petri, Susanne, Wegner, Florian, Grill, Stephan W, Pan-Montojo, Francisco, Hermann, Andreas

“…Amyotrophic lateral sclerosis (ALS) leads to death within 2-5 yr. Currently, available drugs only slightly prolong survival. We present novel insights into the…”
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Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in IFUS/I ALS Motoneurons by Zimyanin, Vitaly L, Pielka, Anna-Maria, Glaß, Hannes, Japtok, Julia, Großmann, Dajana, Ma, Deussen, Andreas, Szewczyk, Barbara, Deppmann, Chris, Zunder, Eli, Andersen, Peter M, Boeckers, Tobias M, Sterneckert, Jared, Redemann, Stefanie, Storch, Alexander, Hermann, Andreas

“…Motoneurons are one of the most energy-demanding cell types and a primary target in Amyotrophic lateral sclerosis (ALS), a debilitating and lethal…”
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