Search Results - "Grizzell, J Alex"

Strategies for the Treatment of Parkinson's Disease: Beyond Dopamine by Iarkov, Alexandre, Barreto, George E, Grizzell, J Alex, Echeverria, Valentina

“…Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra…”
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Neuroinflammation: A Therapeutic Target of Cotinine for the Treatment of Psychiatric Disorders? by Echeverria, Valentina, Grizzell, J Alex, Barreto, George E

“…Neuroinflammation is a common characteristic of several mental health conditions such as major depression, bipolar disorder, post-traumatic stress disorder…”
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Chemogenetic activation of an infralimbic cortex to basolateral amygdala projection promotes resistance to acute social defeat stress by Dulka, Brooke N., Bagatelas, Elena D., Bress, Kimberly S., Grizzell, J. Alex, Cannon, Megan K., Whitten, Conner J., Cooper, Matthew A.

“…Tremendous individual differences exist in stress responsivity and social defeat stress is a key approach for identifying cellular mechanisms of stress…”
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Dominance status alters restraint-induced neural activity in brain regions controlling stress vulnerability by Cooper, Matthew A, Seddighi, Sahba, Barnes, Abigail K, Alex Grizzell, J, Dulka, Brooke N, Clinard, Catherine T

“…Abstract Understanding the cellular mechanisms that control resistance and vulnerability to stress is an important step toward identifying novel targets for…”
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Activity of a vmPFC-DRN Pathway Corresponds With Resistance to Acute Social Defeat Stress by Grizzell, J. Alex, Clarity, Thomas T., Graham, Nate B., Dulka, Brooke N., Cooper, Matthew A.

“…The ventromedial prefrontal cortex (vmPFC) plays a critical role in stress resilience through top-down inhibition of key stress-sensitive limbic and hindbrain…”
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The role of estrogen receptor β and nicotinic cholinergic receptors in postpartum depression by Fernandez, Jamie Winderbaum, Grizzell, J. Alex, Wecker, Lynn

“…Postpartum depression (PPD) is a devastating disease occurring in approximately 20% of women. Women who suffer from PPD appear to be more sensitive to…”
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Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice by Patel, Sagar, Grizzell, J Alex, Holmes, Rosalee, Zeitlin, Ross, Solomon, Rosalynn, Sutton, Thomas L, Rohani, Adeeb, Charry, Laura C, Iarkov, Alexandre, Mori, Takashi, Echeverria Moran, Valentina

“…Alzheimer's disease (AD) is associated with cognitive and non-cognitive symptoms for which there are currently no effective therapies. We have previously…”
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New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine by Grizzell, J. Alex, Echeverria, Valentina

“…Tobacco consumption is far higher among a number of psychiatric and neurological diseases, supporting the notion that some component(s) of tobacco may underlie…”
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Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice by Grizzell, J. Alex, Iarkov, Alexandre, Holmes, Rosalee, Mori, Takahashi, Echeverria, Valentina

“…•Cotinine reduces depressive-like behavior and memory loss in the restrained mice.•Cotinine increases synaptic density in the stressed mouse brains.•Cotinine…”
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Voluntary alcohol consumption during distinct phases of adolescence differentially alters adult fear acquisition, extinction and renewal in male and female rats by Grizzell, J Alex, Vanbaelinghem, Maryam, Westerman, Jessica, Saddoris, Michael P

“…Alcohol use during adolescence coincides with elevated risks of stress-related impairment in adults, particularly via disrupted developmental trajectories of…”
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Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats by Cooper, Matthew A., Grizzell, J. Alex, Whitten, Conner J., Burghardt, Gordon M.

“…Syrian hamsters show complex social play behavior and provide a valuable animal model for delineating the neurobiological mechanisms and functions of social…”
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Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice by Grizzell, J. Alex, Patel, Sagar, Barreto, George E., Echeverria, Valentina

“…Alzheimer's disease (AD) is associated with the progressive aggregation of hyperphosphorylated forms of the microtubule associated protein Tau in the central…”
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Effects of social dominance and acute social stress on morphology of microglia and structural integrity of the medial prefrontal cortex by Grizzell, J. Alex, Clarity, Thomas T., Rodriguez, R. Mason, Marshall, Zachary Q., Cooper, Matthew A.

“…•Acute social defeat alters morphology of microglia in infralimbic cortex.•Dominant hamsters show less reactive microglia and cell damage than…”
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Social Dominance Modulates Stress-induced Neural Activity in Medial Prefrontal Cortex Projections to the Basolateral Amygdala by Dulka, Brooke N., Bress, Kimberly S., Grizzell, J. Alex, Cooper, Matthew A.

“…•The retrograde tracer CTB labeled PL, IL, and vHPC efferents to the hamster amygdala.•Dominants have elevated c-Fos in the PL and IL during acute social…”
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Gonadal steroid hormone receptors in the medial amygdala contribute to experience-dependent changes in stress vulnerability by Cooper, Matthew A., Clinard, Catherine T., Dulka, Brooke N., Grizzell, J. Alex, Loewen, Annie L., Campbell, Ashley V., Adler, Samuel G.

“…Social experience can generate neural plasticity that changes how individuals respond to stress. Winning aggressive encounters alters how animals respond to…”
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Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP+ cells loss induced by restraint stress in mice by Perez-Urrutia, Nelson, Mendoza, Cristhian, Alvarez-Ricartes, Nathalie, Oliveros-Matus, Patricia, Echeverria, Florencia, Grizzell, J. Alex, Barreto, George E., Iarkov, Alexandre, Echeverria, Valentina

“…Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease…”
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Postpartum depression in rats: Differences in swim test immobility, sucrose preference and nurturing behaviors by Fernandez, Jamie Winderbaum, Grizzell, J. Alex, Philpot, Rex M., Wecker, Lynn

“…•Sucrose preference and forced swim immobility varied widely within postpartum dams.•Dams with either low sucrose preference or high immobility exhibit altered…”
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Cotinine Reduces Depressive-Like Behavior and Hippocampal Vascular Endothelial Growth Factor Downregulation After Forced Swim Stress in Mice by Grizzell, J. Alex, Mullins, Michelle, Iarkov, Alexandre, Rohani, Adeeb, Charry, Laura C, Echeverria, Valentina

“…Cotinine, the predominant metabolite of nicotine, appears to act as an antidepressant. We have previously shown that cotinine reduced immobile postures in…”
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A Conceptual Framework for Non-Disposable Assignments: Inspiring Implementation, Innovation, and Research by Seraphin, Sally B., Grizzell, J. Alex, Kerr-German, Anastasia, Perkins, Marjorie A., Grzanka, Patrick R., Hardin, Erin E.

“…The concept of “non-disposable assignments” (NDAs), including those referred to as “renewable assignments,” has grown in popularity in recent years in select…”
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What Happens When Trained Graduate Student Instructors Switch to an Open Textbook? A Controlled Study of the Impact on Student Learning Outcomes by Hardin, Erin E., Eschman, Bret, Spengler, Elliot S., Grizzell, J. Alex, Moody, Anahvia Taiyib, Ross-Sheehy, Shannon, Fry, Kevin M.

“…Open educational resources (OER) are increasingly attractive options for reducing educational costs, yet controlled studies of their efficacy are lacking. The…”
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