Search Results - "Griswold, Anthony"

The intricate cellular ecosystem of human peripheral veins as revealed by single-cell transcriptomic analysis by Rojas, Miguel G, Zigmond, Zachary M, Pereira-Simon, Simone, Santos Falcon, Nieves, Suresh Kumar, Maya, Stoyell-Conti, Filipe F, Kosanovic, Christina, Griswold, Anthony J, Salama, Alghidak, Yang, Xiaofeng, Tabbara, Marwan, Vazquez-Padron, Roberto I, Martinez, Laisel

“…The venous system has been historically understudied despite its critical roles in blood distribution, heart function, and systemic immunity. This study…”
Get full text

Whole Exome Sequencing Identifies a Rare CFTR Mutation in Brothers With Anomalies of the Vas Deferens: A Case Study by Campbell, Katherine, Dullea, Alexandra, Schuppe, Kyle, Ghomeshi, Armin, Ramsoomair, Christian, Griswold, Anthony J., Khodamoradi, Kajal, Ramasamy, Ranjith

“…Congenital bilateral absence of the vas deferens (CBAVD) occurs in almost all men with cystic fibrosis. Prevailing theories on this pathophysiology relate to…”
Get full text

Whole-genome sequencing reveals complex genomic features underlying anti-CD19 CAR T-cell treatment failures in lymphoma by Jain, Michael D., Ziccheddu, Bachisio, Coughlin, Caroline A., Faramand, Rawan, Griswold, Anthony J., Reid, Kayla M., Menges, Meghan, Zhang, Yonghong, Cen, Ling, Wang, Xuefeng, Hussaini, Mohammad, Landgren, Ola, Davila, Marco L., Schatz, Jonathan H., Locke, Frederick L., Maura, Francesco

“…CD19-directed chimeric antigen receptor (CAR-19) T cells are groundbreaking immunotherapies approved for use against large B-cell lymphomas. Although host…”
Get full text

Identification of a genetic variant underlying familial cases of recurrent benign paroxysmal positional vertigo by Xu, Yinfang, Zhang, Yan, Lopez, Ivan A, Hilbers, Jacey, Griswold, Anthony J, Ishiyama, Akira, Blanton, Susan, Liu, Xue Zhong, Lundberg, Yunxia Wang

“…Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo in humans, yet the molecular etiology is currently unknown. Evidence suggests…”
Get full text

Absence of both MGME1 and POLG EXO abolishes mtDNA whereas absence of either creates unique mtDNA duplications by Gonzalez, Christian D., Nissanka, Nadee, Van Booven, Derek, Griswold, Anthony J., Moraes, Carlos T.

“…Both POLG and MGME1 are needed for mitochondrial DNA (mtDNA) maintenance in animal cells. POLG, the primary replicative polymerase of the mitochondria, has an…”
Get full text

Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche by Qadir, Mirza Muhammad Fahd, Álvarez-Cubela, Silvia, Klein, Dagmar, van Dijk, Jasmijn, Muñiz-Anquela, Rocío, Moreno-Hernández, Yaisa B., Lanzoni, Giacomo, Sadiq, Saad, Navarro-Rubio, Belén, García, Michael T., Díaz, Ángela, Johnson, Kevin, Sant, David, Ricordi, Camillo, Griswold, Anthony, Pastori, Ricardo Luis, Domínguez-Bendala, Juan

“…We have described multipotent progenitor-like cells within the major pancreatic ducts (MPDs) of the human pancreas. They express PDX1, its surrogate surface…”
Get full text

Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance by Tan, Sze Kiat, Mahmud, Iqbal, Fontanesi, Flavia, Puchowicz, Michelle, Neumann, Chase K A, Griswold, Anthony J, Patel, Rutulkumar, Dispagna, Marco, Ahmed, Hamzah H, Gonzalgo, Mark L, Brown, J Mark, Garrett, Timothy J, Welford, Scott M

“…Clear cell renal cell carcinoma (ccRCC) is characterized by accumulation of neutral lipids and adipogenic transdifferentiation. We assessed adipokine…”
Get more information

coMethDMR: accurate identification of co-methylated and differentially methylated regions in epigenome-wide association studies with continuous phenotypes by Gomez, Lissette, Odom, Gabriel J, Young, Juan I, Martin, Eden R, Liu, Lizhong, Chen, Xi, Griswold, Anthony J, Gao, Zhen, Zhang, Lanyu, Wang, Lily

“…Recent technology has made it possible to measure DNA methylation profiles in a cost-effective and comprehensive genome-wide manner using array-based…”
Get full text

Whole Exome Sequencing Identifies a Rare Nonsense Mutation in FAM47C as a Possible Cause of Severe Oligospermia in Brothers With Varicocele by Chertman, Willy, Arora, Himanshu, Griswold, Anthony J., Lopategui, Diana M., Ramasamy, Ranjith

“…Varicocele is a common cause of impaired semen parameters in men with infertility. Here, we investigated genetic variants as possible causes of varicocele with…”
Get full text

A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry by Rajabli, Farid, Beecham, Gary W, Hendrie, Hugh C, Baiyewu, Olusegun, Ogunniyi, Adesola, Gao, Sujuan, Kushch, Nicholas A, Lipkin-Vasquez, Marina, Hamilton-Nelson, Kara L, Young, Juan I, Dykxhoorn, Derek M, Nuytemans, Karen, Kunkle, Brian W, Wang, Liyong, Jin, Fulai, Liu, Xiaoxiao, Feliciano-Astacio, Briseida E, Schellenberg, Gerard D, Dalgard, Clifton L, Griswold, Anthony J, Byrd, Goldie S, Reitz, Christiane, Cuccaro, Michael L, Haines, Jonathan L, Pericak-Vance, Margaret A, Vance, Jeffery M

“…African descent populations have a lower Alzheimer disease risk from ApoE ε4 compared to other populations. Ancestry analysis showed that the difference in…”
Get full text

Therapeutic Perspectives for Inflammation and Senescence in Osteoarthritis Using Mesenchymal Stem Cells, Mesenchymal Stem Cell-Derived Extracellular Vesicles and Senolytic Agents by Rizzo, Michael G, Best, Thomas M, Huard, Johnny, Philippon, Marc, Hornicek, Francis, Duan, Zhenfeng, Griswold, Anthony J, Kaplan, Lee D, Hare, Joshua M, Kouroupis, Dimitrios

“…Osteoarthritis (OA) is the most common cause of disability worldwide among the elderly. Alarmingly, the incidence of OA in individuals less than 40 years of…”
Get full text

Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways by GRISWOLD, Anthony J, DEQIONG MA, WRIGHT, Harry H, ABRAMSON, Ruth K, WILLIAMS, Scott M, MENON, Ramkumar, MARTIN, Eden R, HAINES, Jonathan L, GILBERT, John R, CUCCARO, Michael L, PERICAK-VANCE, Margaret A, CUKIER, Holly N, NATIONS, Laura D, SCHMIDT, Mike A, CHUNG, Ren-Hua, JAWORSKI, James M, SALYAKINA, Daria, KONIDARI, Loanna, WHITEHEAD, Patrice L

“…Autism spectrum disorders (ASDs) are highly heritable, yet relatively few associated genetic loci have been replicated. Copy number variations (CNVs) have been…”
Get full text

Infrapatellar Fat Pad/Synovium Complex in Early-Stage Knee Osteoarthritis: Potential New Target and Source of Therapeutic Mesenchymal Stem/Stromal Cells by Greif, Dylan N., Kouroupis, Dimitrios, Murdock, Christopher J., Griswold, Anthony J., Kaplan, Lee D., Best, Thomas M., Correa, Diego

“…The infrapatellar fat pad (IFP) has until recently been viewed as a densely vascular and innervated intracapsular/extrasynovial tissue with biomechanical roles…”
Get full text

A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease by Bai, Haimeng, Naj, Adam C, Benchek, Penelope, Dumitrescu, Logan, Hohman, Timothy, Hamilton-Nelson, Kara, Kallianpur, Asha R, Griswold, Anthony J, Vardarajan, Badri, Martin, Eden R, Beecham, Gary W, Below, Jennifer E, Schellenberg, Gerard, Mayeux, Richard, Farrer, Lindsay, Pericak-Vance, Margaret A, Haines, Jonathan L, Bush, William S

“…Haptoglobin (HP) is an antioxidant of apolipoprotein E (APOE), and previous reports have shown HP binds with APOE and amyloid beta (Aβ) to aid its clearance. A…”
Get full text

Utilizing RNA sequencing to identify gene expression markers of stroke-causing thrombi origin: A pilot study by Atchaneeyasakul, Kunakorn, Bates, Karen E., Toledo, Alyssa, Griswold, Anthony J., Ramdas, Kevin, Watanabe, Mitsuyoshi, Shownkeen, Meghana, Guada, Luis, Yavagal, Dileep

“…Stroke embolic source have an unknown origin in 30-40% of cases. Mechanical thrombectomy for acute large vessel occlusion stroke has provided us with a method…”
Get full text

Alveolar epithelial cell growth hormone releasing hormone receptor in alveolar epithelial inflammation by Cui, Tengjiao, Wangpaichitr, Medhi, Schally, Andrew V., Griswold, Anthony J., Vidaurre, Irving, Sha, Wei, Jackson, Robert M.

Get full text

A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury by Soundararajan, Ramani, Hernández-Cuervo, Helena, Stearns, Timothy M, Griswold, Anthony J, Patil, Sahebgowda Sidramagowda, Fukumoto, Jutaro, Narala, Venkata Ramireddy, Galam, Lakshmi, Lockey, Richard, Kolliputi, Narasaiah

“…Background: Critically ill patients on supplemental oxygen therapy eventually develop acute lung injury (ALI). Reactive oxygen species (ROS) produced during…”
Get full text

Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells by Hardin, Haley M, Dinh, Christine T, Huegel, Julianne, Petrilli, Alejandra M, Bracho, Olena, Allaf, Abdulrahman M, Karajannis, Matthias A, Griswold, Anthony J, Ivan, Michael E, Morcos, Jacques, Gultekin, Sakir H, Telischi, Fred F, Liu, Xue Zhong, Fernandez-Valle, Cristina

“…Neurofibromatosis Type 2 (NF2) is a tumor predisposition syndrome caused by germline inactivating mutations in the NF2 gene encoding the merlin tumor…”
Get full text

Transcriptomics of Human Arteriovenous Fistula Failure: Genes Associated With Nonmaturation by Martinez, Laisel, Tabbara, Marwan, Duque, Juan C., Selman, Guillermo, Falcon, Nieves Santos, Paez, Angela, Griswold, Anthony J., Ramos-Echazabal, Gioser, Hernandez, Diana R., Velazquez, Omaida C., Salman, Loay H., Vazquez-Padron, Roberto I.

“…Improving arteriovenous fistula (AVF) outcomes requires better understanding of the biology underlying maturation or failure. Our current knowledge of…”
Get full text

A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism by Hussman, John P, Chung, Ren-Hua, Griswold, Anthony J, Jaworski, James M, Salyakina, Daria, Ma, Deqiong, Konidari, Ioanna, Whitehead, Patrice L, Vance, Jeffery M, Martin, Eden R, Cuccaro, Michael L, Gilbert, John R, Haines, Jonathan L, Pericak-Vance, Margaret A

“…Genome-wide Association Studies (GWAS) have proved invaluable for the identification of disease susceptibility genes. However, the prioritization of candidate…”
Get full text