Search Results - "Griswold, Andrew R."

The NLRP1 and CARD8 inflammasomes by Taabazuing, Cornelius Y., Griswold, Andrew R., Bachovchin, Daniel A.

“…Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce pyroptosis in response to intracellular danger‐associated signals…”
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N-terminal degradation activates the NLRP1B inflammasome by Chui, Ashley J, Okondo, Marian C, Rao, Sahana D, Gai, Kuo, Griswold, Andrew R, Johnson, Darren C, Ball, Daniel P, Taabazuing, Cornelius Y, Orth, Elizabeth L, Vittimberga, Brooke A, Bachovchin, Daniel A

“…Intracellular pathogens and danger signals trigger the formation of inflammasomes, which activate inflammatory caspases and induce pyroptosis. The anthrax…”
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Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes by Robert Hollingsworth, L., David, Liron, Li, Yang, Griswold, Andrew R., Ruan, Jianbin, Sharif, Humayun, Fontana, Pietro, Orth-He, Elizabeth L., Fu, Tian-Min, Bachovchin, Daniel A., Wu, Hao

“…NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in…”
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Students as Community Vaccinators: Implementation of A Service-Learning COVID-19 Vaccination Program by Griswold, Andrew R, Klein, Julia, Dusaj, Neville, Zhu, Jeff, Keeler, Allegra, Abramson, Erika L, Gurvitch, Dana

“…While the COVID-19 pandemic has caused major educational disruptions, it has also catalyzed innovation in service-learning as a real-time response to…”
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DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation by Hollingsworth, L. Robert, Sharif, Humayun, Griswold, Andrew R., Fontana, Pietro, Mintseris, Julian, Dagbay, Kevin B., Paulo, Joao A., Gygi, Steven P., Bachovchin, Daniel A., Wu, Hao

“…Nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1 (NLRP1) is an inflammasome sensor that mediates the activation of caspase-1…”
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The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells by Griswold, Andrew R, Huang, Hsin-Che, Bachovchin, Daniel A

“…Inflammasomes are multiprotein complexes that detect danger-associated signals and trigger an immunostimulatory form of cell death called pyroptosis. NLRP1 is…”
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Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment by Sharif, Humayun, Hollingsworth, L. Robert, Griswold, Andrew R., Hsiao, Jeffrey C., Wang, Qinghui, Bachovchin, Daniel A., Wu, Hao

“…CARD8 detects intracellular danger signals and forms a caspase-1 activating inflammasome. Like the related inflammasome sensor NLRP1, CARD8 autoprocesses into…”
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A Chemical Strategy for Protease Substrate Profiling by Griswold, Andrew R, Cifani, Paolo, Rao, Sahana D, Axelrod, Abram J, Miele, Matthew M, Hendrickson, Ronald C, Kentsis, Alex, Bachovchin, Daniel A

“…The dipeptidyl peptidases (DPPs) regulate hormones, cytokines, and neuropeptides by cleaving dipeptides after proline from their amino termini. Due to…”
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DPP9’s Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation by Griswold, Andrew R, Ball, Daniel P, Bhattacharjee, Abir, Chui, Ashley J, Rao, Sahana D, Taabazuing, Cornelius Y, Bachovchin, Daniel A

“…Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the…”
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A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome by Hsiao, Jeffrey C., Neugroschl, Atara R., Chui, Ashley J., Taabazuing, Cornelius Y., Griswold, Andrew R., Wang, Qinghui, Huang, Hsin-Che, Orth-He, Elizabeth L., Ball, Daniel P., Hiotis, Giorgos, Bachovchin, Daniel A.

“…CARD8 is a pattern-recognition receptor that forms a caspase-1-activating inflammasome. CARD8 undergoes constitutive autoproteolysis, generating an N-terminal…”
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M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome by Rao, Sahana D., Chen, Qifeng, Wang, Qinghui, Orth-He, Elizabeth L., Saoi, Michelle, Griswold, Andrew R., Bhattacharjee, Abir, Ball, Daniel P., Huang, Hsin-Che, Chui, Ashley J., Covelli, Dominic J., You, Shaochen, Cross, Justin R., Bachovchin, Daniel A.

“…Inflammasomes are multiprotein complexes that sense intracellular danger signals and induce pyroptosis. CARD8 and NLRP1 are related inflammasomes that are…”
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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation by Orth-He, Elizabeth L., Huang, Hsin-Che, Rao, Sahana D., Wang, Qinghui, Chen, Qifeng, O’Mara, Claire M., Chui, Ashley J., Saoi, Michelle, Griswold, Andrew R., Bhattacharjee, Abir, Ball, Daniel P., Cross, Justin R., Bachovchin, Daniel A.

“…NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular danger signals and form inflammasomes. Both undergo autoproteolysis,…”
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Activation of the CARD8 Inflammasome Requires a Disordered Region by Chui, Ashley J., Griswold, Andrew R., Taabazuing, Cornelius Y., Orth, Elizabeth L., Gai, Kuo, Rao, Sahana D., Ball, Daniel P., Hsiao, Jeffrey C., Bachovchin, Daniel A.

“…Several cytosolic pattern-recognition receptors (PRRs) form multiprotein complexes called canonical inflammasomes in response to intracellular danger signals…”
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Caspase-1 interdomain linker cleavage is required for pyroptosis by Ball, Daniel P, Taabazuing, Cornelius Y, Griswold, Andrew R, Orth, Elizabeth L, Rao, Sahana D, Kotliar, Ilana B, Vostal, Lauren E, Johnson, Darren C, Bachovchin, Daniel A

“…Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs) to form canonical inflammasomes, which activate pro-caspase-1 and…”
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Oxidized thioredoxin-1 restrains the NLRP1 inflammasome by Ball, Daniel P, Tsamouri, Lydia P, Wang, Alvin E, Huang, Hsin-Che, Warren, Charles D, Wang, Qinghui, Edmondson, Isabelle H, Griswold, Andrew R, Rao, Sahana D, Johnson, Darren C, Bachovchin, Daniel A

“…The danger signals that activate the NLRP1 inflammasome have not been established. Here, we report that the oxidized, but not the reduced, form of…”
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Characterization of the DPP8/9 Pyroptotic Checkpoints by Griswold, Andrew R

“…The innate immune system wields an arsenal of pattern-recognition receptors (PRRs) to detect cellular danger signals including pathogens and sterile injury…”
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