Search Results - "Gristick, Harry B."

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies by Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.

“…The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding…”
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies by Barnes, Christopher O., West, Anthony P., Huey-Tubman, Kathryn E., Hoffmann, Magnus A.G., Sharaf, Naima G., Hoffman, Pauline R., Koranda, Nicholas, Gristick, Harry B., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. Cetrulo, Finkin, Shlomo, Hägglöf, Thomas, Hurley, Arlene, Millard, Katrina G., Weisblum, Yiska, Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Caskey, Marina, Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal…”
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Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop by Wang, Haoqing, Cohen, Alexander A., Galimidi, Rachel P., Gristick, Harry B., Jensen, Grant J., Bjorkman, Pamela J.

“…The HIV-1 envelope (Env) glycoprotein, a trimer of gp120–gp41 heterodimers, relies on conformational flexibility to function in fusing the viral and host…”
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Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody by Schommers, Philipp, Gruell, Henning, Abernathy, Morgan E., Tran, My-Kim, Dingens, Adam S., Gristick, Harry B., Barnes, Christopher O., Schoofs, Till, Schlotz, Maike, Vanshylla, Kanika, Kreer, Christoph, Weiland, Daniela, Holtick, Udo, Scheid, Christof, Valter, Markus M., van Gils, Marit J., Sanders, Rogier W., Vehreschild, Jörg J., Cornely, Oliver A., Lehmann, Clara, Fätkenheuer, Gerd, Seaman, Michael S., Bloom, Jesse D., Bjorkman, Pamela J., Klein, Florian

“…Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and treat HIV-1 infection. However, viral escape through mutation of the…”
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Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope by Barnes, Christopher O., Gristick, Harry B., Freund, Natalia T., Escolano, Amelia, Lyubimov, Artem Y., Hartweger, Harald, West, Anthony P., Cohen, Aina E., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals inform HIV-1 vaccine design efforts. Developing bNAbs with increased efficacy…”
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Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer by Yang, Zhi, Dam, Kim-Marie A., Bridges, Michael D., Hoffmann, Magnus A. G., DeLaitsch, Andrew T., Gristick, Harry B., Escolano, Amelia, Gautam, Rajeev, Martin, Malcolm A., Nussenzweig, Michel C., Hubbell, Wayne L., Bjorkman, Pamela J.

“…Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We characterize Ab1303 and Ab1573, heterologously-neutralizing…”
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HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design by Dam, Kim-Marie A., Barnes, Christopher O., Gristick, Harry B., Schoofs, Till, Gnanapragasam, Priyanthi N. P., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…BG24, a VRC01-class broadly neutralizing antibody (bNAb) against HIV-1 Env with relatively few somatic hypermutations (SHMs), represents a promising target for…”
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Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4 by Gristick, Harry B, Rao, Meera, Chartron, Justin W, Rome, Michael E, Shan, Shu-ou, Clemons, William M

“…Tail-anchor proteins are targeted post-translationally to the endoplasmic reticulum via the conserved GET pathway, in which the Get4–Get5 complex mediates…”
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Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies by Wang, Haoqing, Gristick, Harry B, Scharf, Louise, West, Anthony P, Galimidi, Rachel P, Seaman, Michael S, Freund, Natalia T, Nussenzweig, Michel C, Bjorkman, Pamela J

“…The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that…”
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A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch by Wang, Zijun, Barnes, Christopher O, Gautam, Rajeev, Cetrulo Lorenzi, Julio C, Mayer, Christian T, Oliveira, Thiago Y, Ramos, Victor, Cipolla, Melissa, Gordon, Kristie M, Gristick, Harry B, West, Anthony P, Nishimura, Yoshiaki, Raina, Henna, Seaman, Michael S, Gazumyan, Anna, Martin, Malcolm, Bjorkman, Pamela J, Nussenzweig, Michel C, Escolano, Amelia

“…A small fraction of HIV-1- infected humans develop broadly neutralizing antibodies (bNAbs) against HIV-1 that protect macaques from simian immunodeficiency HIV…”
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Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope by Abernathy, Morgan E., Gristick, Harry B., Vielmetter, Jost, Keeffe, Jennifer R., Gnanapragasam, Priyanthi N. P., Lee, Yu E., Escolano, Amelia, Gautam, Rajeev, Seaman, Michael S., Martin, Malcolm A., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to…”
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Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site by Gristick, Harry B, von Boehmer, Lotta, West Jr, Anthony P, Schamber, Michael, Gazumyan, Anna, Golijanin, Jovana, Seaman, Michael S, Fätkenheuer, Gerd, Klein, Florian, Nussenzweig, Michel C, Bjorkman, Pamela J

“…Crystal structures of HIV Env trimer with native glycosylation in complex with neutralizing antibodies reveal a glycan shield of high-mannose and complex-type…”
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Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody by Yang, Zhi, Wang, Haoqing, Liu, Albert Z., Gristick, Harry B., Bjorkman, Pamela J.

“…The human immunodeficiency virus (HIV-1) envelope (Env) glycoprotein, a (gp120–gp41) 3 trimer, mediates fusion of viral and host cell membranes after gp120…”
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Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques by Escolano, Amelia, Gristick, Harry B., Abernathy, Morgan E., Merkenschlager, Julia, Gautam, Rajeev, Oliveira, Thiago Y., Pai, Joy, West, Anthony P., Barnes, Christopher O., Cohen, Alexander A., Wang, Haoqing, Golijanin, Jovana, Yost, Daniel, Keeffe, Jennifer R., Wang, Zijun, Zhao, Peng, Yao, Kai-Hui, Bauer, Jens, Nogueira, Lilian, Gao, Han, Voll, Alisa V., Montefiori, David C., Seaman, Michael S., Gazumyan, Anna, Silva, Murillo, McGuire, Andrew T., Stamatatos, Leonidas, Irvine, Darrell J., Wells, Lance, Martin, Malcolm A., Bjorkman, Pamela J., Nussenzweig, Michel C.

“…Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal models, suggesting that a vaccine that elicits these antibodies would…”
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X‐ray and EM structures of a natively glycosylated HIV‐1 envelope trimer by Gristick, Harry B., Wang, Haoqing, Bjorkman, Pamela J.

“…The structural and biochemical characterization of broadly neutralizing anti‐HIV‐1 antibodies (bNAbs) has been essential in guiding the design of potential…”
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Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller by Freund, Natalia T, Wang, Haoqing, Scharf, Louise, Nogueira, Lilian, Horwitz, Joshua A, Bar-On, Yotam, Golijanin, Jovana, Sievers, Stuart A, Sok, Devin, Cai, Hui, Cesar Lorenzi, Julio C, Halper-Stromberg, Ariel, Toth, Ildiko, Piechocka-Trocha, Alicja, Gristick, Harry B, van Gils, Marit J, Sanders, Rogier W, Wang, Lai-Xi, Seaman, Michael S, Burton, Dennis R, Gazumyan, Anna, Walker, Bruce D, West, Jr, Anthony P, Bjorkman, Pamela J, Nussenzweig, Michel C

“…Some HIV-1-infected patients develop broad and potent HIV-1 neutralizing antibodies (bNAbs) that when passively transferred to mice or macaques can treat or…”
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Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells by Hoffmann, Magnus A. G., Bar-On, Yotam, Yang, Zhi, Gristick, Harry B., Gnanapragasam, Priyanthi N. P., Vielmetter, Jost, Nussenzweig, Michel C., Bjorkman, Pamela J.

“…CD4-based decoy approaches against HIV-1 are attractive options for long-term viral control, but initial designs, including soluble CD4 (sCD4) and CD4-Ig, were…”
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Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env by Escolano, Amelia, Gristick, Harry B, Gautam, Rajeev, DeLaitsch, Andrew T, Abernathy, Morgan E, Yang, Zhi, Wang, Haoqing, Hoffmann, Magnus A G, Nishimura, Yoshiaki, Wang, Zijun, Koranda, Nicholas, Kakutani, Leesa M, Gao, Han, Gnanapragasam, Priyanthi N P, Raina, Henna, Gazumyan, Ana, Cipolla, Melissa, Oliveira, Thiago Y, Ramos, Victor, Irvine, Darrell J, Silva, Murillo, West, Jr, Anthony P, Keeffe, Jennifer R, Barnes, Christopher O, Seaman, Michael S, Nussenzweig, Michel C, Martin, Malcolm A, Bjorkman, Pamela J

“…Broadly neutralizing antibodies (bNAbs) against HIV-1 develop after prolonged virus and antibody coevolution. Previous studies showed that sequential…”
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Publisher Correction: Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody by Yang, Zhi, Wang, Haoqing, Liu, Albert Z., Gristick, Harry B., Bjorkman, Pamela J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Publisher Correction: Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody by Yang, Zhi, Wang, Haoqing, Liu, Albert Z., Gristick, Harry B., Bjorkman, Pamela J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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