Search Results - "Gris, Pavel"

NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses by Gris, Denis, Ye, Zhengmao, Iocca, Heather A, Wen, Haitao, Craven, Robin R, Gris, Pavel, Huang, Max, Schneider, Monika, Miller, Stephen D, Ting, Jenny P-Y

“…The interplay between innate and adaptive immunity is important in multiple sclerosis (MS). The inflammasome complex, which activates caspase-1 to process…”
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Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly by Goldman, Jennifer S, Ashour, Mohammed A, Magdesian, Margaret H, Tritsch, Nicolas X, Harris, Stephanie N, Christofi, Nicolas, Chemali, Raja, Stern, Yaakov E, Thompson-Steckel, Greta, Gris, Pavel, Glasgow, Stephen D, Grutter, Peter, Bouchard, Jean-Francois, Ruthazer, Edward S, Stellwagen, David, Kennedy, Timothy E

“…Netrin-1 is a secreted protein that directs long-range axon guidance during early stages of neural circuit formation and continues to be expressed in the…”
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The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis by Gharagozloo, Marjan, Mahvelati, Tara M, Imbeault, Emilie, Gris, Pavel, Zerif, Echarki, Bobbala, Diwakar, Ilangumaran, Subburaj, Amrani, Abdelaziz, Gris, Denis

“…Multiple sclerosis (MS) is an organ-specific autoimmune disease resulting in demyelinating plaques throughout the central nervous system. In MS, the exact role…”
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A Novel Alternatively Spliced Isoform of the Mu-Opioid Receptor: Functional Antagonism by Gris, Pavel, Gauthier, Josee, Cheng, Philip, Gibson, Dustin G, Gris, Denis, Laur, Oskar, Pierson, John, Wentworth, Sean, Nackley, Andrea G, Maixner, William, Diatchenko, Luda

“…Background: Opioids are the most widely used analgesics for the treatment of clinical pain. They produce their therapeutic effects by binding to μ-opioid…”
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Exhaustive Multi-Parametric Assessment of the Behavioral Array of Daily Activities of Mice Using Cluster and Factor Analysis by Yamamoto, Kenzo, Gris, Katsiaryna V, Sotelo Fonseca, Jesús E, Gharagozloo, Marjan, Mahmoud, Shaimaa, Simard, Camille, Houle-Martel, Daphné, Cloutier, Theodore, Gris, Pavel, Gris, Denis

“…Using automated supervised behavioral assessment software, we recorded and analyzed 24 h non-interrupted recordings of mice for a duration of 11 days. With the…”
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Exhaustive behavioral profile assay to detect genotype differences between wild-type, inflammasome-deficient, and Nlrp12 knock-out mice by V Gris, Katsiaryna, Yamamoto, Kenzo, Gharagozloo, Marjan, Mahmoud, Shaimaa, Simard, Camille, Gris, Pavel, Gris, Denis

“…Technological advances in computer vision led to the development of various algorithms that are designed to analyze human and animal behavior. We have used an…”
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Oligodendrocyte Progenitor Cell Susceptibility to Injury in Multiple Sclerosis by Cui, Qiao-Ling, Kuhlmann, Tanja, Miron, Veronique E, Leong, Soo Yuen, Fang, Jun, Gris, Pavel, Kennedy, Timothy E, Almazan, Guillermina, Antel, Jack

“…Remyelination in multiple sclerosis (MS) is often incomplete. In experimental models, oligodendrocyte progenitor cells (OPCs) rather than previously…”
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Nlrx1 regulates neuronal cell death by Imbeault, Emilie, Mahvelati, Tara M, Braun, Ralf, Gris, Pavel, Gris, Denis

“…Regulation of cell death during neurodegeneration is one of the key factors that play a role in the speed at which a disease progresses. Out of several…”
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Relative Expression of Anti-Oxidant Genes in Adult Human Progenitor and Mature Oligodendrocytes (S12.005) by Cui, Qiao Ling, Gris, Pavel, Kennedy, Timothy, Antel, Jack

“…Abstract only…”
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Identification and characterization of novel candidate compounds targeting 6‐ and 7‐transmembrane μ‐opioid receptor isoforms by Muralidharan, Arjun, Samoshkin, Alexander, Convertino, Marino, Piltonen, Marjo Hannele, Gris, Pavel, Wang, Jian, Jiang, Changyu, Klares, Richard, Linton, Alexander, Ji, Ru‐Rong, Maixner, William, Dokholyan, Nikolay V., Mogil, Jeffrey S., Diatchenko, Luda

“…Background and Purpose The μ‐opioid receptor (μ receptor) is the primary target for opioid analgesics. The 7‐transmembrane (TM) and 6TM μ receptor isoforms…”
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Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons by Khoury, Samar, Wang, Qiao-Ping, Parisien, Marc, Gris, Pavel, Bortsov, Andrey V, Linnstaedt, Sarah D, McLean, Samuel A, Tungate, Andrew S, Sofer, Tamar, Lee, Jiwon, Louie, Tin, Redline, Susan, Kaunisto, Mari Anneli, Kalso, Eija A, Munter, Hans Markus, Nackley, Andrea G, Slade, Gary D, Smith, Shad B, Zaykin, Dmitri V, Fillingim, Roger B, Ohrbach, Richard, Greenspan, Joel D, Maixner, William, Neely, G Gregory, Diatchenko, Luda

“…Abstract Poor sleep quality can have harmful health consequences. Although many aspects of sleep are heritable, the understandings of genetic factors involved…”
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Expansion of the human μ-opioid receptor gene architecture: novel functional variants by Shabalina, Svetlana A., Zaykin, Dmitri V., Gris, Pavel, Ogurtsov, Aleksey Y., Gauthier, Josee, Shibata, Kyoko, Tchivileva, Inna E., Belfer, Inna, Mishra, Bikashkumar, Kiselycznyk, Carly, Wallace, Margaret R., Staud, Roland, Spiridonov, Nikolay A., Max, Mitchell B., Goldman, David, Fillingim, Roger B., Maixner, William, Diatchenko, Luda

“…The μ-opioid receptor (OPRM1) is the principal receptor target for both endogenous and exogenous opioid analgesics. There are substantial individual…”
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Oligodendrocyte Progenitor Cells (OPCs) from Adult Human Brain Expressed Distinct microRNAs Compared to OPCs in Development (P1.155) by Leong, Soo Yuen, Rao, Vijayaraghava, Bin, Jenea, Gris, Pavel, Sangaralingam, Mugundhine, Kennedy, Timothy, Antel, Jack

“…Abstract only…”
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Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation by Wu, Celina, Leong, Soo Y, Moore, Craig S, Cui, Qiao Ling, Gris, Pavel, Bernier, Louis-Philippe, Johnson, Trina A, Séguéla, Philippe, Kennedy, Timothy E, Bar-Or, Amit, Antel, Jack P

“…FTY720 (fingolimod, Gilenya) is a daily oral therapy for multiple sclerosis that readily accesses the central nervous system (CNS). FTY720 is a structural…”
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Heterogeneity of oligodendrocyte progenitor cells in adult human brain by Leong, Soo Yuen, Rao, Vijayaraghava T. S., Bin, Jenea M., Gris, Pavel, Sangaralingam, Mugundhine, Kennedy, Timothy E., Antel, Jack P.

“…Objective Remyelination in multiple sclerosis has been attributed to the presence of oligodendrocyte progenitor cells (OPCs) in brain parenchyma. However, the…”
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Molecular assays for characterization of alternatively spliced isoforms of the u opioid receptor (MOR) by Gris, Pavel, Cheng, Philip, Pierson, John, Maixner, William, Diatchenko, Luda

“…Mu-opioid receptor (MOR) belongs to a family of heptahelical G-protein-coupled receptors (GPCRs). Studies in humans and rodents demonstrated that the OPRM1…”
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Expansion of the human [mu]-opioid receptor gene architecture: novel functional variants by Shabalina, Svetlana A, Zaykin, Dmitri V, Gris, Pavel, Ogurtsov, Aleksey Y, Gauthier, Josee, Shibata, Kyoko, Tchivileva, Inna E, Belfer, Inna, Mishra, Bikashkumar, Kiselycznyk, Carly, Wallace, Margaret R, Staud, Roland, Spiridonov, Nikolay A, Max, Mitchell B, Goldman, David, Fillingim, Roger B, Maixner, William, Diatchenko, Luda

“…The μ-opioid receptor (OPRM1) is the principal receptor target for both endogenous and exogenous opioid analgesics. There are substantial individual…”
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Expansion of the human k-opioid receptor gene architecture: novel functional variants by Shabalina, Svetlana A, Zaykin, Dmitri V, Gris, Pavel, Ogurtsov, Aleksey Y, Gauthier, Josee, Shibata, Kyoko, Tchivileva, Inna E, Belfer, Inna, Mishra, Bikashkumar, Kiselycznyk, Carly, Wallace, Margaret R, Staud, Roland, Spiridonov, Nikolay A, Max, Mitchell B, Goldman, David, Fillingim, Roger B, Maixner, William, Diatchenko, Luda

“…The k-opioid receptor (OPRM1) is the principal receptor target for both endogenous and exogenous opioid analgesics. There are substantial individual…”
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Strategies to identify differentially regulated genetic programs after spinal cord injury by Gris, Pavel

“…This dissertation studied changes in the regulation of genetic programs following spinal cord injury (SCI). The hypothesis of the study is that the analysis of…”
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