Search Results - "Gris, Georgia"

Intestinal inflammation-associated hypersensitivity is attenuated in a DSS model of colitis in Sigma-1 knockout C57BL/6 mice by López-Estévez, Sergio, Gris, Georgia, de la Puente, Beatriz, Carceller, Alicia, Martínez, Vicente

“…Sigma-1 receptors (σ1R) have been implicated in several pain pathways. We assessed the implication of σ1Rs in the development of intestinal inflammation and…”
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Genetic and Pharmacological Blockade of Sigma-1 Receptors Attenuates Inflammation-Associated Hypersensitivity during Acute Colitis in CD1 Mice by López-Estévez, Sergio, Aguilera, Mònica, Gris, Georgia, de la Puente, Beatriz, Carceller, Alicia, Martínez, Vicente

“…Sigma-1 receptors (σ1Rs) are implicated in nociception, including pain sensitization, and inflammation. We assessed the role of σ1Rs on acute…”
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Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice by Castany, Sílvia, Gris, Georgia, Vela, José Miguel, Verdú, Enrique, Boadas-Vaello, Pere

“…Sigma-1 receptor (σ 1 R) knockout (KO) CD1 mice, generated by homologous recombination, and separate pharmacological studies in wild type (WT) mice were done…”
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The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats by Gris, Georgia, Portillo-Salido, Enrique, Aubel, Bertrand, Darbaky, Yassine, Deseure, Kristof, Vela, José Miguel, Merlos, Manuel, Zamanillo, Daniel

“…E-52862 is a selective σ 1 R antagonist currently undergoing phase II clinical trials for neuropathic pain and represents a potential first-in-class analgesic…”
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Sigma-1 receptor and inflammatory pain by Gris, Georgia, Cobos, Enrique José, Zamanillo, Daniel, Portillo-Salido, Enrique

“…Introduction The sigma-1 receptor (Sig-1R) is a unique ligand-regulated molecular chaperone that interacts with several protein targets such as G…”
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Propionamide Derivatives as Dual μ-Opioid Receptor Agonists and σ 1 Receptor Antagonists for the Treatment of Pain by García, Mónica, Llorente, Virginia, Garriga, Lourdes, Christmann, Ute, Rodríguez-Escrich, Sergi, Virgili, Marina, Fernández, Begoña, Bordas, Magda, Ayet, Eva, Burgueño, Javier, Pujol, Marta, Dordal, Albert, Portillo-Salido, Enrique, Gris, Georgia, Vela, José Miguel, Almansa, Carmen

“…A new series of propionamide derivatives was developed as dual μ-opioid receptor agonists and σ receptor antagonists. Modification of a high-throughput…”
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Propionamide Derivatives as Dual μ‑Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain by García, Mónica, Llorente, Virginia, Garriga, Lourdes, Christmann, Ute, Rodríguez-Escrich, Sergi, Virgili, Marina, Fernández, Begoña, Bordas, Magda, Ayet, Eva, Burgueño, Javier, Pujol, Marta, Dordal, Albert, Portillo-Salido, Enrique, Gris, Georgia, Vela, José Miguel, Almansa, Carmen

“…A new series of propionamide derivatives was developed as dual μ-opioid receptor agonists and σ1 receptor antagonists. Modification of a high-throughput…”
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Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective sigma-1 ligands and sigma-1 knockout mice by Entrena, José Manuel, Cobos, Enrique José, Nieto, Francisco Rafael, Cendán, Cruz Miguel, Gris, Georgia, Del Pozo, Esperanza, Zamanillo, Daniel, Baeyens, José Manuel

“…We evaluated the role of σ1 receptors on capsaicin-induced mechanical hypersensitivity and on nociceptive pain induced by punctate mechanical stimuli, using…”
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S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund’s adjuvant models in mice by Gris, Georgia, Merlos, Manuel, Vela, José M, Zamanillo, Daniel, Portillo-Salido, Enrique

“…The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in…”
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