Search Results - "Grinspan, Judith B"

Oxidative stress disrupts oligodendrocyte maturation by French, Heather Morein, Reid, Mary, Mamontov, Polina, Simmons, Rebecca A., Grinspan, Judith B.

“…Periventricular white matter injury (PWMI) is the leading cause of chronic neurologic injury among survivors of preterm birth. The hallmark of PWMI is…”
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Delayed Myelination in an Intrauterine Growth Retardation Model Is Mediated by Oxidative Stress Upregulating Bone Morphogenetic Protein 4 by Reid, Mary V, Murray, Kaitlin A, Marsh, Eric D, Golden, Jeffrey A, Simmons, Rebecca A, Grinspan, Judith B

“…ABSTRACTIntrauterine growth retardation (IUGR) is associated with neurological deficits including cerebral palsy and cognitive and behavioral disabilities. The…”
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Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination by Bloom, Mara S., Orthmann-Murphy, Jennifer, Grinspan, Judith B.

“…The idea that myelination is driven by both intrinsic and extrinsic cues has gained much traction in recent years. Studies have demonstrated that myelination…”
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Update on Central Nervous System Effects of HIV in Adolescents and Young Adults by McGuire, Jennifer L., Grinspan, Judith B., Jordan-Sciutto, Kelly L.

“…Purpose of Review. Behaviorally acquired (non-perinatal) HIV infection during adolescence and young adulthood occurs in the midst of key brain developmental…”
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Reduced sterol regulatory element‐binding protein (SREBP) processing through site‐1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro by Monnerie, Hubert, Romer, Micah, Jensen, Brigid K., Millar, John S., Jordan‐Sciutto, Kelly L., Kim, Sangwon F., Grinspan, Judith B.

“…The formation of the myelin membrane of the oligodendrocyte in the CNS is a fundamental process requiring the coordinated synthesis of many different…”
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Inducible knockout of Clec16a in mice results in sensory neurodegeneration by Hain, Heather S., Pandey, Rahul, Bakay, Marina, Strenkowski, Bryan P., Harrington, Danielle, Romer, Micah, Motley, William W., Li, Jian, Lancaster, Eunjoo, Roth, Lindsay, Grinspan, Judith B., Scherer, Steven S., Hakonarson, Hakon

“…CLEC16A has been shown to play a role in autophagy/mitophagy processes. Additionally, genetic variants in CLEC16A have been implicated in multiple autoimmune…”
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Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures by Monnerie, Hubert, Romer, Micah, Roth, Lindsay M, Long, Caela, Millar, John S, Jordan-Sciutto, Kelly L, Grinspan, Judith B

“…Combined antiretroviral therapy (cART) has greatly decreased mortality and morbidity among persons with HIV; however, neurologic impairments remain prevalent,…”
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Magnetic cell sorting: A fast and effective method of concurrent isolation of high purity viable astrocytes and microglia from neonatal mouse brain tissue by Marek, Ryan, Caruso, Michael, Rostami, Abdolmohamad, Grinspan, Judith. B., Sarma, Jayasri Das

“…Pathologically altered functions of astrocytes and microglia play a pivotal role in diseases of the central nervous system (CNS). The complexity of the CNS…”
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Reducing Th2 inflammation through neutralizing IL-4 antibody rescues myelination in IUGR rat brain by Zanno, Allison E, Romer, Micah A, Fox, Lauren, Golden, Thea, Jaeckle-Santos, Lane, Simmons, Rebecca A, Grinspan, Judith B

“…Intrauterine growth restriction (IUGR) is a common complication of pregnancy and is associated with significant neurological deficits in infants, including…”
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Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis by Ara, Jahan, See, Jill, Mamontov, Polina, Hahn, Ashleigh, Bannerman, Peter, Pleasure, David, Grinspan, Judith B.

“…Although spontaneous remyelination occurs in multiple sclerosis (MS), the extent of myelin repair is often inadequate to restore normal function…”
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Inhibitors of Myelination and Remyelination, Bone Morphogenetic Proteins, are Upregulated in Human Neurological Disease by Grinspan, Judith B.

“…During demyelinating disease such as multiple sclerosis and stroke, myelin is destroyed and along with it, the oligodendrocytes that synthesize the myelin…”
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Gliopathy of Demyelinating and Non-Demyelinating Strains of Mouse Hepatitis Virus by Kenyon, Lawrence C, Biswas, Kaushiki, Shindler, Kenneth S, Nabar, Manasi, Stout, Marjorie, Hingley, Susan T, Grinspan, Judith B, Das Sarma, Jayasri

“…Demyelination in the central nervous system induced by neurovirulent strains of Mouse Hepatitis Virus (MHV) is mediated by the viral spike glycoprotein, but it…”
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White matter injury across neurodegenerative disease by Festa, Lindsay K, Grinspan, Judith B, Jordan-Sciutto, Kelly L

“…Oligodendrocytes (OLs), the myelin-generating cells of the central nervous system (CNS), are active players in shaping neuronal circuitry and function. It has…”
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Canonical Wnt signalling requires the BMP pathway to inhibit oligodendrocyte maturation by Feigenson, Keith, Reid, Mary, See, Jill, Crenshaw III, E Bryan, Grinspan, Judith B

“…OLs (oligodendrocytes) are the myelinating cells of the CNS (central nervous system), wrapping axons in conductive sheathes to ensure effective transmission of…”
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Bone Morphogenetic Proteins: Inhibitors of Myelination in Development and Disease by Grinspan, Judith B

“…Myelin, the lipid membrane that surrounds axons, is critical for the propagation of nervous impulses and axonal maintenance. The destruction of myelin or lack…”
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3285 Toxicity of Released B Cell Products in Multiple Sclerosis: Effects on Neurons and Oligodendrocytes by Zuroff, Leah, Touil, Hanane, Romer, Micah, Nedelkoska, Liljana, Benjamins, Joyce A., Lisak, Robert P., Grinspan, Judith B., Bar-Or, Amit

“…OBJECTIVES/SPECIFIC AIMS: We previously demonstrated that products released by cultured B cells from patients with Multiple Sclerosis (MS) are cytotoxic to…”
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White matter loss and oligodendrocyte dysfunction in HIV: A consequence of the infection, the antiretroviral therapy or both? by Jensen, Brigid K., Roth, Lindsay M., Grinspan, Judith B., Jordan-Sciutto, Kelly L.

“…•White matter abnormalities are persistent in HIV+ individuals with HAND.•This may be due to HIV reservoirs in the CNS, side effects of antiretroviral…”
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Axonal Interactions Regulate Schwann Cell Apoptosis in Developing Peripheral Nerve: Neuregulin Receptors and the Role of Neuregulins by Grinspan, Judith B, Marchionni, Mark A, Reeves, Matthew, Coulaloglou, Markella, Scherer, Steven S

“…Programmed cell death during development resulting from the lack of appropriate survival factors has been demonstrated in both neurons and oligodendrocytes and…”
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Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response by Roth, Lindsay M., Zidane, Bassam, Festa, Lindsay, Putatunda, Raj, Romer, Micah, Monnerie, Hubert, Jordan‐Sciutto, Kelly L., Grinspan, Judith B.

“…Regardless of adherence to combined antiretroviral therapy, white matter and myelin pathologies persist in patients with HIV‐associated neurocognitive…”
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HIV‐induced neuroinflammation inhibits oligodendrocyte maturation via glutamate‐dependent activation of the PERK arm of the integrated stress response by Roth, Lindsay M., Akay‐Espinoza, Cagla, Grinspan, Judith B., Jordan‐Sciutto, Kelly L.

“…Despite combined antiretroviral therapy (cART), HIV‐associated neurocognitive disorder (HAND) affects 30–50% of HIV‐positive patients. Importantly, persistent…”
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