Search Results - "Grininger, Martin"

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production by Gajewski, Jan, Pavlovic, Renata, Fischer, Manuel, Boles, Eckhard, Grininger, Martin

“…Fatty acids (FAs) are considered strategically important platform compounds that can be accessed by sustainable microbial approaches. Here we report the…”
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Protein denaturation at the air-water interface and how to prevent it by D'Imprima, Edoardo, Floris, Davide, Joppe, Mirko, Sánchez, Ricardo, Grininger, Martin, Kühlbrandt, Werner

“…Electron cryo-microscopy analyzes the structure of proteins and protein complexes in vitrified solution. Proteins tend to adsorb to the air-water interface in…”
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Fatty Acid Biosynthesis: Chain‐Length Regulation and Control by Heil, Christina S., Wehrheim, S. Sophia, Paithankar, Karthik S., Grininger, Martin

“…De novo biosynthesis of fatty acids is an iterative process requiring strict regulation of the lengths of the produced fatty acids. In this review, we focus on…”
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Type I fatty acid synthase trapped in the octanoyl‐bound state by Rittner, Alexander, Paithankar, Karthik S., Himmler, Aaron, Grininger, Martin

“…De novo fatty acid biosynthesis in humans is accomplished by a multidomain protein, the Type I fatty acid synthase (FAS). Although ubiquitously expressed in…”
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Substrate promiscuity of polyketide synthase enables production of tsetse fly attractants 3-ethylphenol and 3-propylphenol by engineering precursor supply in yeast by Hitschler, Julia, Grininger, Martin, Boles, Eckhard

“…Tsetse flies are the transmitting vector of trypanosomes causing human sleeping sickness and animal trypanosomiasis in sub-saharan Africa. 3-alkylphenols are…”
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Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering by Rittner, Alexander, Paithankar, Karthik S, Huu, Khanh Vu, Grininger, Martin

“…Fatty acid synthases (FASs) and polyketide synthases (PKSs) condense acyl compounds to fatty acids and polyketides, respectively. Both, FASs and PKSs, harbor…”
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The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds by Buyachuihan, Lynn, Reiners, Simon, Zhao, Yue, Grininger, Martin

“…Modular polyketide synthases (PKSs) play a vital role in the biosynthesis of complex natural products with pharmaceutically relevant properties. Their modular…”
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Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins by Fischer, Manuel, Grininger, Martin

“…Megasynthases are large multienzyme proteins that produce a plethora of important natural compounds by catalyzing the successive condensation and modification…”
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Pathway and protein engineering for biosynthesis by Zhou, Yongjin, Grininger, Martin, Alper, Hal

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Structural insights into the mechanism of archaellar rotational switching by Altegoer, Florian, Quax, Tessa E. F., Weiland, Paul, Nußbaum, Phillip, Giammarinaro, Pietro I., Patro, Megha, Li, Zhengqun, Oesterhelt, Dieter, Grininger, Martin, Albers, Sonja-Verena, Bange, Gert

“…Signal transduction via phosphorylated CheY towards the flagellum and the archaellum involves a conserved mechanism of CheY phosphorylation and subsequent…”
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CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function by Han, Xu, D'Angelo, Cecilia, Otamendi, Ainara, Cifuente, Javier O, de Astigarraga, Elisa, Ochoa-Lizarralde, Borja, Grininger, Martin, Routier, Francoise H, Guerin, Marcelo E, Fuehring, Jana, Etxebeste, Oier, Connell, Sean R

“…Invasive aspergillosis is one of the most serious clinical invasive fungal infections, resulting in a high case fatality rate among immunocompromised patients…”
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The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase by Joppe, Mirko, D'Imprima, Edoardo, Salustros, Nina, Paithankar, Karthik S, Vonck, Janet, Grininger, Martin, Kühlbrandt, Werner

“…Single-particle electron cryo-microscopy (cryoEM) has undergone a 'resolution revolution' that makes it possible to characterize megadalton (MDa) complexes at…”
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Enzymology of assembly line synthesis by modular polyketide synthases by Grininger, Martin

“…Modular polyketide synthases (PKSs) run catalytic reactions over dozens of steps in a highly orchestrated manner. To accomplish this synthetic feat, they form…”
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Inhibition of the Fungal Fatty Acid Synthase Type I Multienzyme Complex by Johansson, Patrik, Wiltschi, Birgit, Kumari, Preeti, Kessler, Brigitte, Vonrhein, Clemens, Vonck, Janet, Oesterhelt, Dieter, Grininger, Martin

“…Fatty acids are among the major building blocks of living cells, making lipid biosynthesis a potent target for compounds with antibiotic or antineoplastic…”
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Dodecin Is the Key Player in Flavin Homeostasis of Archaea by Grininger, Martin, Staudt, Heike, Johansson, Patrik, Wachtveitl, Josef, Oesterhelt, Dieter

“…Flavins are employed to transform physical input into biological output signals. In this function, flavins catalyze a variety of light-induced reactions and…”
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Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy by Gipson, Preeti, Mills, Deryck J, Wouts, Remco, Grininger, Martin, Vonck, Janet, Kühlbrandt, Werner

“…Yeast fatty acid synthase (FAS) is a 2.6-MDa barrel-shaped multienzyme complex, which carries out cyclic synthesis of fatty acids. By electron cryomicroscopy…”
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Solution Structure and Conformational Flexibility of a Polyketide Synthase Module by Klaus, Maja, Rossini, Emanuele, Linden, Andreas, Paithankar, Karthik S, Zeug, Matthias, Ignatova, Zoya, Urlaub, Henning, Khosla, Chaitan, Köfinger, Jürgen, Hummer, Gerhard, Grininger, Martin

“…Polyketide synthases (PKSs) are versatile C-C bond-forming enzymes that are broadly distributed in bacteria and fungi. The polyketide compound family includes…”
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Direct structural analysis of a single acyl carrier protein domain in fatty acid synthase from the fungus Saccharomyces cerevisiae by Samani, Elnaz Khalili, Chen, Amy C., Lou, Jennifer W., Dai, David L., Keszei, Alexander F. A., Tan, Guihong, Boone, Charles, Grininger, Martin, Mazhab-Jafari, Mohammad T.

“…Acyl carrier protein (ACP) is the work horse of polyketide (PKS) and fatty acid synthases (FAS) and acts as a substrate shuttling domain in these mega enzymes…”
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Multimeric Options for the Auto-Activation of the Saccharomyces cerevisiae FAS Type I Megasynthase by Johansson, Patrik, Mulinacci, Barbara, Koestler, Caecilia, Vollrath, Ronnald, Oesterhelt, Dieter, Grininger, Martin

“…The fungal type I fatty acid synthase (FAS) is a 2.6 MDa multienzyme complex, catalyzing all necessary steps for the synthesis of long acyl chains. To be…”
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The role of the iterative modules in polyketide synthase evolution by Grininger, Martin

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