Search Results - "Gringhuis, Sonja I."

Fungal Engagement of the C-Type Lectin Mincle Suppresses Dectin-1-Induced Antifungal Immunity by Wevers, Brigitte A., Kaptein, Tanja M., Zijlstra-Willems, Esther M., Theelen, Bart, Boekhout, Teun, Geijtenbeek, Teunis B.H., Gringhuis, Sonja I.

“…Recognition of fungal pathogens by C-type lectin receptor (CLR) dectin-1 on human dendritic cells is essential for triggering protective antifungal TH1 and…”
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Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis , HIV-1 and Helicobacter pylori by van der Vlist, Michiel, Gringhuis, Sonja I, den Dunnen, Jeroen, Litjens, Manja, Geijtenbeek, Teunis B H

“…Different pathogens induce different cytokine production via the C-type lectin DC-SIGN. Geijtenbeek and colleagues show that distinct carbohydrates on the…”
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Antagonism of the Phosphatase PP1 by the Measles Virus V Protein Is Required for Innate Immune Escape of MDA5 by Davis, Meredith E., Wang, May K., Rennick, Linda J., Full, Florian, Gableske, Sebastian, Mesman, Annelies W., Gringhuis, Sonja I., Geijtenbeek, Teunis B.H., Duprex, W. Paul, Gack, Michaela U.

“…The cytosolic sensor MDA5 is crucial for antiviral innate immune defense against various RNA viruses including measles virus; as such, many viruses…”
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DDX3 in HIV-1 infection and sensing: A paradox by Stunnenberg, Melissa, Geijtenbeek, Teunis B.H., Gringhuis, Sonja I.

“…•Following HIV-1 infection of dendritic cells, viral DNA and RNA are sensed by different host immune sensors.•The RNA helicase DDX3 is indispensable for…”
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HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells by Geijtenbeek, Teunis B H, van der Vlist, Michiel, van den Berg, Linda M, den Dunnen, Jeroen, Gringhuis, Sonja I, Litjens, Manja

“…HIV-1 replication requires proviral production of full-length transcripts. Geijtenbeek and colleagues show that early Tat-independent HIV-1 replication coopts…”
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HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3 by Gringhuis, Sonja I, Hertoghs, Nina, Kaptein, Tanja M, Zijlstra-Willems, Esther M, Sarrami-Forooshani, Ramin, Sprokholt, Joris K, van Teijlingen, Nienke H, Kootstra, Neeltje A, Booiman, Thijs, van Dort, Karel A, Ribeiro, Carla M S, Drewniak, Agata, Geijtenbeek, Teunis B H

“…Gringhuis, Geijtenbeek and colleagues show that the RNA helicase DDX3 binds abortive HIV-1 RNA and induces type I interferon in dendritic cells, a process that…”
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RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production by Sprokholt, Joris K, Kaptein, Tanja M, van Hamme, John L, Overmars, Ronald J, Gringhuis, Sonja I, Geijtenbeek, Teunis B H

“…Follicular T helper cells (TFH) are fundamental in orchestrating effective antibody-mediated responses critical for immunity against viral infections and…”
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RIG-I–like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation by Sprokholt, Joris K., Kaptein, Tanja M., van Hamme, John L., Overmars, Ronald J., Gringhuis, Sonja I., Geijtenbeek, Teunis B. H.

“…Abstract Dengue virus (DENV) causes 400 million infections annually and is one of several viruses that can cause viral hemorrhagic fever, which is…”
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Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants by Wilbers, Ruud H. P., Westerhof, Lotte B., van Noort, Kim, Obieglo, Katja, Driessen, Nicole N., Everts, Bart, Gringhuis, Sonja I., Schramm, Gabriele, Goverse, Aska, Smant, Geert, Bakker, Jaap, Smits, Hermelijn H., Yazdanbakhsh, Maria, Schots, Arjen, Hokke, Cornelis H.

“…Helminth parasites control host-immune responses by secreting immunomodulatory glycoproteins. Clinical trials and mouse model studies have demonstrated the…”
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Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2 by Gringhuis, Sonja I., Wevers, Brigitte A., Kaptein, Tanja M., van Capel, Toni M. M., Theelen, Bart, Boekhout, Teun, de Jong, Esther C., Geijtenbeek, Teunis B. H.

“…C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of TH1 and TH-17 cellular…”
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Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling by Schreibelt, Gerty, Kooij, Gijs, Reijerkerk, Arie, van Doorn, Ruben, Gringhuis, Sonja I, van der Pol, Susanne, Weksler, Babette B, Romero, Ignacio A, Couraud, Pierre-Olivier, Piontek, Jörg, Blasig, Ingolf E, Dijkstra, Christine D, Ronken, Eric, de Vries, Helga E

“…The blood-brain barrier (BBB) prevents the entrance of circulating molecules and immune cells into the central nervous system. The barrier is formed by…”
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An evolutionary perspective on C-type lectins in infection and immunity by van den Berg, Linda M., Gringhuis, Sonja I., Geijtenbeek, Teunis B.H.

“…Host–pathogen interactions have coevolved for many years. On the one hand, the human immune system consists of innate and adaptive immune cells that function…”
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Innate signaling by the C-type lectin DC-SIGN dictates immune responses by den Dunnen, Jeroen, Gringhuis, Sonja I, Geijtenbeek, Teunis B. H

“…Effective immune responses depend on the recognition of pathogens by dendritic cells (DCs) through pattern recognition receptors (PRRs). These receptors induce…”
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Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity by Stunnenberg, Melissa, Sprokholt, Joris K, van Hamme, John L, Kaptein, Tanja M, Zijlstra-Willems, Esther M, Gringhuis, Sonja I, Geijtenbeek, Teunis B H

“…Strong innate and adaptive immune responses are paramount in combating viral infections. Dendritic cells (DCs) detect viral infections via cytosolic RIG-I like…”
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Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization by Hovius, Joppe W R, de Jong, Marein A W P, den Dunnen, Jeroen, Litjens, Manja, Fikrig, Erol, van der Poll, Tom, Gringhuis, Sonja I, Geijtenbeek, Teunis B H

“…Ixodes ticks are major vectors for human pathogens, such as Borrelia burgdorferi, the causative agent of Lyme disease. Tick saliva contains immunosuppressive…”
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MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4 + T Cell Infection in HIV-1-Infected Individuals by Stunnenberg, Melissa, van Pul, Lisa, Sprokholt, Joris K, van Dort, Karel A, Gringhuis, Sonja I, Geijtenbeek, Teunis B H, Kootstra, Neeltje A

“…The mitochondrial antiviral protein MAVS is a key player in the induction of antiviral responses; however, human immunodeficiency virus 1 (HIV-1) is able to…”
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C-type lectin receptors in the control of T helper cell differentiation by Geijtenbeek, Teunis B. H., Gringhuis, Sonja I.

“…Key Points C-type lectin receptors (CLRs) are efficient pattern-recognition receptors (PRRs) that interact with pathogens via carbohydrate structures, leading…”
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Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases by Mesman, Annelies W., Zijlstra-Willems, Esther M., Kaptein, Tanja M., de Swart, Rik L., Davis, Meredith E., Ludlow, Martin, Duprex, W. Paul, Gack, Michaela U., Gringhuis, Sonja I., Geijtenbeek, Teunis B.H.

“…Dendritic cells (DCs) are targets of measles virus (MV) and play central roles in viral dissemination. However, DCs express the RIG-I-like receptors (RLRs)…”
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Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome by Gringhuis, Sonja I, Kaptein, Tanja M, Wevers, Brigitte A, Theelen, Bart, van der Vlist, Michiel, Boekhout, Teun, Geijtenbeek, Teunis B H

“…Production of the proinflammatory cytokine IL-1β is crucial in host defense. Geijtenbeek and colleagues show that dectin-1 signaling in response to fungi and…”
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Signalling through C-type lectin receptors: shaping immune responses by Gringhuis, Sonja I, Geijtenbeek, Teunis B. H

“…Key Points Crosstalk between pattern recognition receptors (PRRs) expressed by dendritic cells orchestrates T helper (T H ) cell differentiation through the…”
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