Neural and Glial Regulation of Angiogenesis in CNS in Ischemic Stroke

Neural and Glial Regulation of Angiogenesis in CNS in Ischemic Stroke

CNS diseases associated with compromised blood supply and/or vascular integrity are one of the leading causes of mortality and disability in adults worldwide and are also among 10 most common causes of death in children. Angiogenesis is an essential element of regeneration processes upon nervous tis...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 177; no. 4; pp. 528 - 533
Main Authors: Grinchevskaya, L. R., Salikhova, D. I., Silachev, D. N., Goldshtein, D. V.
Format: Journal Article
Language:English
Published: New York Springer US 01-08-2024
Springer Nature B.V
Subjects:
Angiogenesis
Astrocytes
Biomedical and Life Sciences
Biomedicine
Blood vessels
Blood-brain barrier
Brain
Brain injury
Brain-derived neurotrophic factor
Cell Biology
Cell death
Endothelial cells
Hypoxia
Internal Medicine
Ischemia
Kinases
Laboratory Medicine
Microglia
Neural stem cells
Neurogenesis
Neuronal-glial interactions
Neuroprotection
Oligodendrocytes
Pathology
Permeability
Postpartum period
Proteins
Regeneration
Signal transduction
Stem cells
Stroke
Vascular endothelial growth factor
vascular regeneration
regulation of angiogenesis in CNS
CNS blood vessels
angiogenesis
neurovascular unit
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Summary:CNS diseases associated with compromised blood supply and/or vascular integrity are one of the leading causes of mortality and disability in adults worldwide and are also among 10 most common causes of death in children. Angiogenesis is an essential element of regeneration processes upon nervous tissue damage and can play a crucial role in neuroprotection. Here we review the features of cerebral vascular regeneration after ischemic stroke, including the complex interactions between endothelial cells and other brain cell types (neural stem cells, astrocytes, microglia, and oligodendrocytes). The mechanisms of reciprocal influence of angiogenesis and neurogenesis, the role of astrocytes in the formation of the blood—brain barrier, and roles of microglia and oligodendrocytes in vascular regeneration are discussed. Understanding the mechanisms of angiogenesis regulation in CNS is of critical importance for the development of new treatments of neurovascular pathologies.
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ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06219-4