Search Results - "Grin, Inga R"

A Low-Activity Polymorphic Variant of Human NEIL2 DNA Glycosylase by Kakhkharova, Zarina I, Zharkov, Dmitry O, Grin, Inga R

“…Human NEIL2 DNA glycosylase (hNEIL2) is a base excision repair protein that removes oxidative lesions from DNA. A distinctive feature of hNEIL2 is its…”
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Base Excision DNA Repair in Plants: Arabidopsis and Beyond by Grin, Inga R., Petrova, Daria V., Endutkin, Anton V., Ma, Chunquan, Yu, Bing, Li, Haiying, Zharkov, Dmitry O.

“…Base excision DNA repair (BER) is a key pathway safeguarding the genome of all living organisms from damage caused by both intrinsic and environmental factors…”
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Genome-wide analysis of WD40 protein family and functional characterization of BvWD40-82 in sugar beet by Wu, Zhirui, Zhang, Tingyue, Li, Jinna, Chen, Sixue, Grin, Inga R, Zharkov, Dmitry O, Yu, Bing, Li, Haiying

“…Sugar beet is one of the most important sugar crops in the world. It contributes greatly to the global sugar production, but salt stress negatively affects the…”
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A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme by Grin, Inga R., Mechetin, Grigory V., Kasymov, Rustem D., Diatlova, Evgeniia A., Yudkina, Anna V., Shchelkunov, Sergei N., Gileva, Irina P., Denisova, Alexandra A., Stepanov, Grigoriy A., Chilov, Ghermes G., Zharkov, Dmitry O.

“…Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the…”
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Noncatalytic Domains in DNA Glycosylases by Torgasheva, Natalia A., Diatlova, Evgeniia A., Grin, Inga R., Endutkin, Anton V., Mechetin, Grigory V., Vokhtantsev, Ivan P., Yudkina, Anna V., Zharkov, Dmitry O.

“…Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic…”
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The role of mammalian NEIL1 protein in the repair of 8-oxo-7,8-dihydroadenine in DNA by Grin, Inga R., Dianov, Grigory L., Zharkov, Dmitry O.

“…8-oxo-7,8-dihydroadenine (8-oxoAde) is a major product of adenine modification by reactive oxygen species. So far, only one mammalian DNA glycosylase,…”
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Cloning and characterization of a wheat homologue of apurinic/apyrimidinic endonuclease Ape1L by Joldybayeva, Botagoz, Prorok, Paulina, Grin, Inga R, Zharkov, Dmitry O, Ishenko, Alexander A, Tudek, Barbara, Bissenbaev, Amangeldy K, Saparbaev, Murat

“…Apurinic/apyrimidinic (AP) endonucleases are key DNA repair enzymes involved in the base excision repair (BER) pathway. In BER, an AP endonuclease cleaves DNA…”
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Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases by Prorok, Paulina, Grin, Inga R., Matkarimov, Bakhyt T., Ishchenko, Alexander A., Laval, Jacques, Zharkov, Dmitry O., Saparbaev, Murat

“…It was proposed that the last universal common ancestor (LUCA) evolved under high temperatures in an oxygen-free environment, similar to those found in…”
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Data set on the synthesis and properties of 2′,3′-dideoxyuridine triphosphate conjugated to SiO2 nanoparticles by Vasilyeva, Svetlana V., Grin, Inga R., Chelobanov, Boris P., Stetsenko, Dmitry A.

“…SiO2 nanoparticles were used as a transport system for cellular delivery of phosphorylated 2′,3′-dideoxyuridine to increase its anticancer potency. This data…”
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The dual role of methylglyoxal in plant stress response and regulation of DJ ‐1 protein by Sun, Yutong, Chen, Sixue, Grin, Inga R., Zharkov, Dmitry O., Yu, Bing, Li, Haiying

“…Methylglyoxal (MG) is a highly reactive metabolic intermediate that plays important roles in plant salt stress response. This review explores the sources of MG…”
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Deoxyribophosphate lyase activity of mammalian endonuclease VIII-like proteins by Grin, Inga R., Khodyreva, Svetlana N., Nevinsky, Georgy A., Zharkov, Dmitry O.

“…Base excision repair (BER) protects cells from nucleobase DNA damage. In eukaryotic BER, DNA glycosylases generate abasic sites, which are then converted to…”
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Reading Targeted DNA Damage in the Active Demethylation Pathway: Role of Accessory Domains of Eukaryotic AP Endonucleases and Thymine-DNA Glycosylases by Popov, Alexander V., Grin, Inga R., Dvornikova, Antonina P., Matkarimov, Bakhyt T., Groisman, Regina, Saparbaev, Murat, Zharkov, Dmitry O.

“…Base excision DNA repair (BER) is an important process used by all living organisms to remove nonbulky lesions from DNA. BER is usually initiated by DNA…”
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Conformational Dynamics of Damage Processing by Human DNA Glycosylase NEIL1 by Kladova, Olga A., Grin, Inga R., Fedorova, Olga S., Kuznetsov, Nikita A., Zharkov, Dmitry O.

“…Endonuclease VIII-like protein 1 (NEIL1) is a DNA repair enzyme found in higher eukaryotes, including humans. It belongs to the helix–two turn–helix (H2TH)…”
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Oxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation by Gruber, David R, Toner, Joanna J, Miears, Heather L, Shernyukov, Andrey V, Kiryutin, Alexey S, Lomzov, Alexander A, Endutkin, Anton V, Grin, Inga R, Petrova, Darya V, Kupryushkin, Maxim S, Yurkovskaya, Alexandra V, Johnson, Eric C, Okon, Mark, Bagryanskaya, Elena G, Zharkov, Dmitry O, Smirnov, Serge L

“…Abstract DNA damage can affect various regulatory elements of the genome, with the consequences for DNA structure, dynamics, and interaction with proteins…”
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2′,3′-Dideoxyuridine triphosphate conjugated to SiO2 nanoparticles: Synthesis and evaluation of antiproliferative activity by Vasilyeva, Svetlana V., Grin, Inga R., Chelobanov, Boris P., Stetsenko, Dmitry A.

“…[Display omitted] •Phosphorylated dideoxyuridine (ddU) with SiO2 nanoparticles conjugate was obtained.•The conjugate was shown to be potent killer of MCF7…”
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2',3'-Dideoxyuridine triphosphate conjugated to SiO 2 nanoparticles: Synthesis and evaluation of antiproliferative activity by Vasilyeva, Svetlana V, Grin, Inga R, Chelobanov, Boris P, Stetsenko, Dmitry A

“…A conjugate of triphosphorylated 2',3'-dideoxyuridine (ddU) with SiO nanoparticles was obtained via the CuAAC click chemistry between a γ-alkynyl ddU…”
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Photoinduced inhibition of DNA repair enzymes and the possible mechanism of photochemical transformations of the ruthenium nitrosyl complex [RuNO(β-Pic)(NO)OH] by Mikhailov, Artem A, Khantakova, Darya V, Nichiporenko, Vladislav A, Glebov, Evgeni M, Grivin, Vjacheslav P, Plyusnin, Victor F, Yanshole, Vadim V, Petrova, Daria V, Kostin, Gennadiy A, Grin, Inga R

“…In this work we have demonstrated that the ruthenium nitrosyl complex [RuNO(β-Pic) 2 (NO 2 ) 2 OH] is suitable for investigation of the inactivation of DNA…”
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Displacement of Slow-Turnover DNA Glycosylases by Molecular Traffic on DNA by Yudkina, Anna V, Endutkin, Anton V, Diatlova, Eugenia A, Moor, Nina A, Vokhtantsev, Ivan P, Grin, Inga R, Zharkov, Dmitry O

“…In the base excision repair pathway, the initiating enzymes, DNA glycosylases, remove damaged bases and form long-living complexes with the abasic DNA product,…”
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Excision of 8-oxoguanine from methylated CpG dinucleotides by human 8-oxoguanine DNA glycosylase by Kasymov, Rustem D., Grin, Inga R., Endutkin, Anton V., Smirnov, Serge L., Ishchenko, Alexander A., Saparbaev, Murat K., Zharkov, Dmitry O.

“…•CpG dinucleotides, sites of epigenetic methylation, are often oxidized at guanines.•Removal of 8-oxoguanine from CpG is partly hindered by cytosine…”
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Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding by Grin, Inga R., Rieger, Robert A., Zharkov, Dmitry O.

“…Pyridoxal-5′-phosphate (PLP), in addition to its known metabolic functions, inactivates many DNA-dependent enzymes through conjugation to their critical amino…”
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