Search Results - "Grimsrud, Paul A."

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation by McDonnell, Eoin, Crown, Scott B., Fox, Douglas B., Kitir, Betül, Ilkayeva, Olga R., Olsen, Christian A., Grimsrud, Paul A., Hirschey, Matthew D.

“…Cells integrate nutrient sensing and metabolism to coordinate proper cellular responses to a particular nutrient source. For example, glucose drives a gene…”
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A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation by Wagner, Gregory R, Bhatt, Dhaval P, O'Connell, Thomas M, Thompson, J Will, Dubois, Laura G, Backos, Donald S, Yang, Hao, Mitchell, Grant A, Ilkayeva, Olga R, Stevens, Robert D, Grimsrud, Paul A, Hirschey, Matthew D

“…The mechanisms underlying the formation of acyl protein modifications remain poorly understood. By investigating the reactivity of endogenous acyl-CoA…”
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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase by White, Phillip J., McGarrah, Robert W., Grimsrud, Paul A., Tso, Shih-Chia, Yang, Wen-Hsuan, Haldeman, Jonathan M., Grenier-Larouche, Thomas, An, Jie, Lapworth, Amanda L., Astapova, Inna, Hannou, Sarah A., George, Tabitha, Arlotto, Michelle, Olson, Lyra B., Lai, Michelle, Zhang, Guo-Fang, Ilkayeva, Olga, Herman, Mark A., Wynn, R. Max, Chuang, David T., Newgard, Christopher B.

“…Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood…”
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Oxidative Stress and Covalent Modification of Protein with Bioactive Aldehydes by Grimsrud, Paul A., Xie, Hongwei, Griffin, Timothy J., Bernlohr, David A.

“…The term “oxidative stress” links the production of reactive oxygen species to a variety of metabolic outcomes, including insulin resistance, immune…”
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A Quantitative Map of the Liver Mitochondrial Phosphoproteome Reveals Posttranslational Control of Ketogenesis by Grimsrud, Paul A., Carson, Joshua J., Hebert, Alex S., Hubler, Shane L., Niemi, Natalie M., Bailey, Derek J., Jochem, Adam, Stapleton, Donald S., Keller, Mark P., Westphall, Michael S., Yandell, Brian S., Attie, Alan D., Coon, Joshua J., Pagliarini, David J.

“…Mitochondria are dynamic organelles that play a central role in a diverse array of metabolic processes. Elucidating mitochondrial adaptations to changing…”
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Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction by Williams, Ashley S., Koves, Timothy R., Davidson, Michael T., Crown, Scott B., Fisher-Wellman, Kelsey H., Torres, Maria J., Draper, James A., Narowski, Tara M., Slentz, Dorothy H., Lantier, Louise, Wasserman, David H., Grimsrud, Paul A., Muoio, Deborah M.

“…This study sought to examine the functional significance of mitochondrial protein acetylation using a double knockout (DKO) mouse model harboring…”
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The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins by Davies, Michael N., Kjalarsdottir, Lilja, Thompson, J. Will, Dubois, Laura G., Stevens, Robert D., Ilkayeva, Olga R., Brosnan, M. Julia, Rolph, Timothy P., Grimsrud, Paul A., Muoio, Deborah M.

“…Lysine acetylation (AcK), a posttranslational modification wherein a two-carbon acetyl group binds covalently to a lysine residue, occurs prominently on…”
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Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload by Hershberger, Kathleen A., Abraham, Dennis M., Liu, Juan, Locasale, Jason W., Grimsrud, Paul A., Hirschey, Matthew D.

“…Mitochondrial Sirtuin 5 (SIRT5) is an NAD+-dependent demalonylase, desuccinylase, and deglutarylase that controls several metabolic pathways. A number of…”
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Statin therapy inhibits fatty acid synthase via dynamic protein modifications by Trub, Alec G., Wagner, Gregory R., Anderson, Kristin A., Crown, Scott B., Zhang, Guo-Fang, Thompson, J. Will, Ilkayeva, Olga R., Stevens, Robert D., Grimsrud, Paul A., Kulkarni, Rhushikesh A., Backos, Donald S., Meier, Jordan L., Hirschey, Matthew D.

“…Statins are a class of drug widely prescribed for the prevention of cardiovascular disease, with pleiotropic cellular effects. Statins inhibit HMG-CoA…”
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Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition by Peterson, Brett S., Campbell, Jonathan E., Ilkayeva, Olga, Grimsrud, Paul A., Hirschey, Matthew D., Newgard, Christopher B.

“…SIRT3 is a nicotinamide adenine dinucleotide (NAD+)-dependent mitochondrial protein deacetylase purported to influence metabolism through post-translational…”
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Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics by Fisher-Wellman, Kelsey H., Draper, James A., Davidson, Michael T., Williams, Ashley S., Narowski, Tara M., Slentz, Dorothy H., Ilkayeva, Olga R., Stevens, Robert D., Wagner, Gregory R., Najjar, Rami, Hirschey, Mathew D., Thompson, J. Will, Olson, David P., Kelly, Daniel P., Koves, Timothy R., Grimsrud, Paul A., Muoio, Deborah M.

“…Acyl CoA metabolites derived from the catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of…”
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Proteomics and phosphoproteomics datasets of a muscle-specific STIM1 loss-of-function mouse model by Lyons, Scott P., Wilson, Rebecca J., Muoio, Deborah M., Grimsrud, Paul A.

“…STIM1 is an ER/SR transmembrane protein that interacts with ORAI1 to activate store operated Ca2+ entry (SOCE) upon ER/SR depletion of calcium. Normally highly…”
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Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass by Wilson, Rebecca J., Lyons, Scott P., Koves, Timothy R., Bryson, Victoria G., Zhang, Hengtao, Li, TianYu, Crown, Scott B., Ding, Jin-Dong, Grimsrud, Paul A., Rosenberg, Paul B., Muoio, Deborah M.

“…Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store…”
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Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome by Williams, Ashley S., Koves, Timothy R., Pettway, Yasminye D., Draper, James A., Slentz, Dorothy H., Grimsrud, Paul A., Ilkayeva, Olga R., Muoio, Deborah M.

“…Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide…”
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HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis by Sargsyan, Ashot, Doridot, Ludivine, Hannou, Sarah A, Tong, Wenxin, Srinivasan, Harini, Ivison, Rachael, Monn, Ruby, Kou, Henry H, Haldeman, Jonathan M, Arlotto, Michelle, White, Phillip J, Grimsrud, Paul A, Astapova, Inna, Tsai, Linus T, Herman, Mark A

“…Carbohydrate response element-binding protein (ChREBP) is a carbohydrate-sensing transcription factor that regulates both adaptive and maladaptive genomic…”
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Leveraging proteomics to understand plant-microbe interactions by Jayaraman, Dhileepkumar, Forshey, Kari L, Grimsrud, Paul A, Ané, Jean-Michel

“…Understanding the interactions of plants with beneficial and pathogenic microbes is a promising avenue to improve crop productivity and agriculture…”
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Medicago PhosphoProtein Database: a repository for Medicago truncatula phosphoprotein data by Rose, Christopher M, Venkateshwaran, Muthusubramanian, Grimsrud, Paul A, Westphall, Michael S, Sussman, Michael R, Coon, Joshua J, Ané, Jean-Michel

“…The ability of legume crops to fix atmospheric nitrogen via a symbiotic association with soil rhizobia makes them an essential component of many agricultural…”
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SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion by Anderson, Kristin A, Huynh, Frank K, Fisher-Wellman, Kelsey, Stuart, J Darren, Peterson, Brett S, Douros, Jonathan D, Wagner, Gregory R, Thompson, J Will, Madsen, Andreas S, Green, Michelle F, Sivley, R Michael, Ilkayeva, Olga R, Stevens, Robert D, Backos, Donald S, Capra, John A, Olsen, Christian A, Campbell, Jonathan E, Muoio, Deborah M, Grimsrud, Paul A, Hirschey, Matthew D

“…Sirtuins are NAD -dependent protein deacylases that regulate several aspects of metabolism and aging. In contrast to the other mammalian sirtuins, the primary…”
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Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure by Davidson, Michael T., Grimsrud, Paul A., Lai, Ling, Draper, James A., Fisher-Wellman, Kelsey H., Narowski, Tara M., Abraham, Dennis M., Koves, Timothy R., Kelly, Daniel P., Muoio, Deborah M.

“…RATIONALE:Circumstantial evidence links the development of heart failure to posttranslational modifications of mitochondrial proteins, including lysine…”
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Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles by Koves, Timothy R., Zhang, Guo-Fang, Davidson, Michael T., Chaves, Alec B., Crown, Scott B., Johnson, Jordan M., Slentz, Dorothy H., Grimsrud, Paul A., Muoio, Deborah M.

“…Even-chain acylcarnitine (AC) metabolites, most of which are generated as byproducts of incomplete fatty acid oxidation (FAO), are viewed as biomarkers of…”
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