Search Results - "Grimson, Andrew"

Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs by Baek, Daehyun, Bartel, David P, Garcia, David M, Shin, Chanseok, Bell, George W, Grimson, Andrew

“…A single miRNA can target hundreds of distinct transcripts, but some miRNAs such as C. elegans lsy-6 have very low target proficiency. The reasons behind this…”
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Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals by Bartel, David P, Grimson, Andrew, Srivastava, Mansi, Fahey, Bryony, Woodcroft, Ben J, Chiang, H. Rosaria, King, Nicole, Degnan, Bernard M, Rokhsar, Daniel S

“…In bilaterian animals, such as humans, flies and worms, hundreds of microRNAs (miRNAs), some conserved throughout bilaterian evolution, collectively regulate a…”
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Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing by Grive, Kathryn J, Hu, Yang, Shu, Eileen, Grimson, Andrew, Elemento, Olivier, Grenier, Jennifer K, Cohen, Paula E

“…Spermatogenesis is the process by which male gametes are formed from a self-renewing population of spermatogonial stem cells (SSCs) residing in the testis…”
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MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing by Grimson, Andrew, Farh, Kyle Kai-How, Johnston, Wendy K., Garrett-Engele, Philip, Lim, Lee P., Bartel, David P.

“…Mammalian microRNAs (miRNAs) pair to 3′UTRs of mRNAs to direct their posttranscriptional repression. Important for target recognition are ∼7 nt sites that…”
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Extracellular vesicle‐associated organotropic metastasis by Mo, Zhenzhen, Cheong, Jia Yang Alex, Xiang, Lirong, Le, Minh T. N., Grimson, Andrew, Zhang, Daniel Xin

“…Metastasis refers to the progressive dissemination of primary tumour cells and their colonization of other tissues and is associated with most cancer‐related…”
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Evolutionary dynamics of microRNA target sites across vertebrate evolution by Simkin, Alfred, Geissler, Rene, McIntyre, Alexa B R, Grimson, Andrew

“…MicroRNAs (miRNAs) control the abundance of the majority of the vertebrate transcriptome. The recognition sequences, or target sites, for bilaterian miRNAs are…”
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Systematic analysis of the Hmga2 3' UTR identifies many independent regulatory sequences and a novel interaction between distal sites by Kristjánsdóttir, Katla, Fogarty, Elizabeth A, Grimson, Andrew

“…The 3' untranslated regions (3' UTRs) of mRNAs regulate transcripts by serving as binding sites for regulatory factors, including microRNAs and RNA binding…”
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miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction by Guda, Swaroopa, Brendel, Christian, Renella, Raffaele, Du, Peng, Bauer, Daniel E, Canver, Matthew C, Grenier, Jennifer K, Grimson, Andrew W, Kamran, Sophia C, Thornton, James, de Boer, Helen, Root, David E, Milsom, Michael D, Orkin, Stuart H, Gregory, Richard I, Williams, David A

“…RNA interference (RNAi) technology using short hairpin RNAs (shRNAs) expressed via RNA polymerase (pol) III promoters has been widely exploited to modulate…”
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A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1 by Geissler, Rene, Simkin, Alfred, Floss, Doreen, Patel, Ravi, Fogarty, Elizabeth A, Scheller, Jürgen, Grimson, Andrew

“…3'-untranslated regions (UTRs) specify post-transcriptional fates of mammalian messenger RNAs (mRNAs), yet knowledge of the underlying sequences and mechanisms…”
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Aberrant gene expression by Sertoli cells in infertile men with Sertoli cell-only syndrome by Paduch, Darius A, Hilz, Stephanie, Grimson, Andrew, Schlegel, Peter N, Jedlicka, Anne E, Wright, William W

“…Sertoli cell-only (SCO) syndrome is a severe form of human male infertility seemingly characterized by the lack all spermatogenic cells. However, tubules of…”
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Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution by Farh, Kyle Kai-How, Grimson, Andrew, Jan, Calvin, Lewis, Benjamin P, Johnston, Wendy K, Lim, Lee P, Burge, Christopher B, Bartel, David P

“…Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-nucleotide sites matching microRNAs (miRNAs). We found that these conserved…”
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Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b by Vu, Luyen Tien, Peng, Boya, Zhang, Daniel Xin, Ma, Victor, Mathey-Andrews, Camille A., Lam, Chun Kuen, Kiomourtzis, Theodoros, Jin, Jingmin, McReynolds, Larry, Huang, Linfeng, Grimson, Andrew, Cho, William C., Lieberman, Judy, Le, Minh Tn

“…Tumour cells release large quantities of extracellular vesicles (EVs) to mediate their interactions with other cells in the tumour microenvironment. To…”
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The Notch signaling pathway promotes basophil responses during helminth-induced type 2 inflammation by Webb, Lauren M, Oyesola, Oyebola O, Früh, Simon P, Kamynina, Elena, Still, Katherine M, Patel, Ravi K, Peng, Seth A, Cubitt, Rebecca L, Grimson, Andrew, Grenier, Jennifer K, Harris, Tajie H, Danko, Charles G, Tait Wojno, Elia D

“…Type 2 inflammation drives the clearance of gastrointestinal helminth parasites, which infect over two billion people worldwide. Basophils are innate immune…”
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A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation by Ascenção, Carolline, Sims, Jennie R, Dziubek, Alexis, Comstock, William, Fogarty, Elizabeth A, Badar, Jumana, Freire, Raimundo, Grimson, Andrew, Weiss, Robert S, Cohen, Paula E, Smolka, Marcus B

“…Meiotic sex chromosome inactivation (MSCI) is a critical feature of meiotic prophase I progression in males. While the ATR kinase and its activator TOPBP1 are…”
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Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males by Modzelewski, Andrew J, Hilz, Stephanie, Crate, Elizabeth A, Schweidenback, Caterina T H, Fogarty, Elizabeth A, Grenier, Jennifer K, Freire, Raimundo, Cohen, Paula E, Grimson, Andrew

“…Small RNAs play crucial roles in regulating gene expression during mammalian meiosis. To investigate the function of microRNAs (miRNAs) and small interfering…”
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Plasma metabolomics reveals disrupted response and recovery following maximal exercise in myalgic encephalomyelitis/chronic fatigue syndrome by Germain, Arnaud, Giloteaux, Ludovic, Moore, Geoffrey E, Levine, Susan M, Chia, John K, Keller, Betsy A, Stevens, Jared, Franconi, Carl J, Mao, Xiangling, Shungu, Dikoma C, Grimson, Andrew, Hanson, Maureen R

“…Post-exertional malaise (PEM) is a hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We monitored the evolution of 1157 plasma…”
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Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the “Guilt-by-Association” Principle by Guo, Yu, Wei, Xiaomu, Das, Jishnu, Grimson, Andrew, Lipkin, Steven M., Clark, Andrew G., Yu, Haiyuan

“…To better understand different molecular mechanisms by which mutations lead to various human diseases, we classified 82,833 disease-associated mutations…”
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Phosphorylation of hUPF1 Induces Formation of mRNA Surveillance Complexes Containing hSMG-5 and hSMG-7 by Ohnishi, Tetsuo, Yamashita, Akio, Kashima, Isao, Schell, Thomas, Anders, Kirk R., Grimson, Andrew, Hachiya, Takahisa, Hentze, Matthias W., Anderson, Philip, Ohno, Shigeo

“…Eukaryotic mRNAs containing premature termination codons (PTCs) are degraded by a process known as nonsense-mediated mRNA decay (NMD). NMD has been suggested…”
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αvβ1 integrin is enriched in extracellular vesicles of metastatic breast cancer cells: A mechanism mediated by galectin‐3 by Zhang, Daniel Xin, Dang, Xuan T. T., Vu, Luyen Tien, Lim, Claudine Ming Hui, Yeo, Eric Yew Meng, Lam, Brenda Wan Shing, Leong, Sai Mun, Omar, Noorjehan, Putti, Thomas Choudary, Yeh, Yu Chen, Ma, Victor, Luo, Jia‐Yuan, Cho, William C., Chen, Gang, Lee, Victor Kwan Min, Grimson, Andrew, Le, Minh T. N.

“…Breast cancer cells release a large quantity of biocargo‐bearing extracellular vesicles (EVs), which mediate intercellular communication within the tumour…”
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SMG-1 Is a Phosphatidylinositol Kinase-Related Protein Kinase Required for Nonsense-Mediated mRNA Decay in Caenorhabditis elegans by Grimson, Andrew, O'Connor, Sean, Newman, Carrie Loushin, Anderson, Philip

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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