Search Results - "Grimm, Stefanie"

Biphenyl based stationary phases for improved selectivity in complex steroid assays by Lindner, Johanna M., Vogeser, Michael, Grimm, Stefanie H.

“…•Comprehensive steroid isotope-dilution LC–MS based assay.•Biphenyl based stationary phases are a powerful tool for steroid assays.•Zinc trifluoroacetate in…”
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Lipofuscin-bound iron is a major intracellular source of oxidants: Role in senescent cells by Höhn, Annika, Jung, Tobias, Grimm, Stefanie, Grune, Tilman

“…Aging is accompanied by an intracellular accumulation of lipofuscin, a hydrophobic yellow-brownish material that accumulates especially in the lysosomal…”
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Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1 by Grimm, Stefanie, Ott, Christiane, Hörlacher, Melanie, Weber, Daniela, Höhn, Annika, Grune, Tilman

“…AGEs (advanced glycation-end products) accumulate during aging and several pathologies such as Alzheimer's disease and diabetes. These protein products are…”
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Lipofuscin inhibits the proteasome by binding to surface motifs by Höhn, Annika, Jung, Tobias, Grimm, Stefanie, Catalgol, Betül, Weber, Daniela, Grune, Tilman

“…Lipofuscin, a highly oxidized aggregate, consists of covalently cross-linked proteins, lipids, and sugar residues and is one of the major life-span-limiting…”
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Estimating the Value-at-Risk by Temporal VAE by Buch, Robert, Grimm, Stefanie, Korn, Ralf, Richert, Ivo

“…Estimation of the value-at-risk (VaR) of a large portfolio of assets is an important task for financial institutions. As the joint log-returns of asset prices…”
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Isotope Inversion Experiment evaluating the suitability of calibration in surrogate matrix for quantification via LC–MS/MS—Exemplary application for a steroid multi-method by Suhr, Anna Catharina, Vogeser, Michael, Grimm, Stefanie H.

“…[Display omitted] •Semi-automated on-line SPE UHPLC–MS/MS method addressing six corticosteroids.•Surrogate matrix calibration for quantification of endogenous…”
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Short-Term Air Pollution Forecasting Using Embeddings in Neural Networks by Ramentol, Enislay, Grimm, Stefanie, Stinzendörfer, Moritz, Wagner, Andreas

“…Air quality is a highly relevant issue for any developed economy. The high incidence of pollution levels and their impact on human health has attracted the…”
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Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts by Höhn, Annika, Sittig, Anna, Jung, Tobias, Grimm, Stefanie, Grune, Tilman

“…In the current literature, the lysosomal system is considered to be involved in the intracellular formation and accumulation of lipofuscin, a highly oxidized…”
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MS Binding Assays for the Three Monoamine Transporters Using the Triple Reuptake Inhibitor (1R,3S)-Indatraline as Native Marker by Grimm, Stefanie H., Höfner, Georg, Wanner, Klaus T.

“…We herein present label‐free, mass‐spectrometry‐based binding assays (MS Binding Assays) for the human dopamine, norepinephrine, and serotonin transporters…”
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The dynamics of a serum steroid profile after stimulation with intravenous ACTH by Lindner, Johanna M., Suhr, Anna Catharina, Grimm, Stefanie H., Möhnle, Patrick, Vogeser, Michael, Briegel, Josef

“…•An extended steroid profile displays highly dynamic response to IV ACTH stimulation.•Far more pronounced relative increase of corticosterone compared to…”
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An LC-MS/MS based candidate reference method for the quantification of total gentamicin in human serum and plasma using NMR characterized calibrator material by Lucha, Stephanie, Taibon, Judith, Pongratz, Stephan, Geletneky, Christian, Huber, Erasmus, Wintterle-Roehm, Christine, Lang, Robert, Grimm, Stefanie H., Duelffer, Thomas, Tarasov, Kirill, Zander, Johannes, Vogeser, Michael, Kobold, Uwe

“…Accurate measurement of gentamicin concentration in serum and plasma is required for therapeutic drug monitoring to ensure appropriate treatment of patients…”
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Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays by Grimm, Stefanie H., Höfner, Georg, Wanner, Klaus T.

“…We herein present the first LC-MS/MS quantification method for indatraline, a highly potent nonselective inhibitor of the three monoamine transporters (for…”
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Ferromagnetic particles as a rapid and robust sample preparation for the absolute quantification of seven eicosanoids in human plasma by UHPLC–MS/MS by Suhr, Anna Catharina, Bruegel, Mathias, Maier, Barbara, Holdt, Lesca Miriam, Kleinhempel, Alisa, Teupser, Daniel, Grimm, Stefanie H., Vogeser, Michael

“…•Use of ferromagnetic particles as novel deproteination technique.•Combination of magnetic particles with on-line SPE for high through-put…”
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A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression by Bayram, Banu, Ozcelik, Beraat, Grimm, Stefanie, Roeder, Thomas, Schrader, Charlotte, Ernst, Insa M A, Wagner, Anika E, Grune, Tilman, Frank, Jan, Rimbach, Gerald

“…A Mediterranean diet rich in olive oil has been associated with health benefits in humans. It is unclear if and to what extent olive oil phenolics may mediate…”
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The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1 by Grimm, Stefanie, Mvondo, Dagmar, Grune, Tilman, Breusing, Nicolle

“…Photodynamic therapy (PDT) is an important clinical approach for cancer treatment. It involves the administration of a photosensitizer, followed by its…”
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Back Cover: MS Binding Assays for the Three Monoamine Transporters Using the Triple Reuptake Inhibitor (1R,3S)-Indatraline as Native Marker (ChemMedChem 6/2015) by Grimm, Stefanie H., Höfner, Georg, Wanner, Klaus T.

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Enantiopurity Determination of the Enantiomers of the Triple Reuptake Inhibitor Indatraline by Grimm, Stefanie H., Allmendinger, Lars, Höfner, Georg, Wanner, Klaus T.

“…ABSTRACT The present study describes the development of two approaches for the determination of the enantiopurity of both enantiomers of indatraline…”
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A semi-automated, isotope-dilution high-resolution mass spectrometry assay for therapeutic drug monitoring of antidepressants by Lindner, Johanna M, Vogeser, Michael, Sorg, Katharina, Grimm, Stefanie H

“…Therapeutic drug monitoring (TDM) of antidepressants is important to ensure compliance and to rule out pharmacokinetic abnormalities. Therefore, reliable…”
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Protein damage, repair and proteolysis by Chondrogianni, Niki, Petropoulos, Isabelle, Grimm, Stefanie, Georgila, Konstantina, Catalgol, Betul, Friguet, Bertrand, Grune, Tilman, Gonos, Efstathios S.

“…Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged proteins influence several intracellular pathways and result in…”
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Discrete-time implementation of continuous-time filters with application to regime-switching dynamics estimation by Grimm, Stefanie, Erlwein-Sayer, Christina, Mamon, Rogemar

“…This paper details the implementation in discrete time of filters for a mean-reverting model formulated under a continuous-time framework, whereby a hidden…”
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