Search Results - "Grimm, Hans"

In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell-Mediated Tumor Killing by Lehmann, Steffi, Perera, Ramanil, Grimm, Hans-Peter, Sam, Johannes, Colombetti, Sara, Fauti, Tanja, Fahrni, Linda, Schaller, Teilo, Freimoser-Grundschober, Anne, Zielonka, Jörg, Stoma, Szymon, Rudin, Markus, Klein, Christian, Umana, Pablo, Gerdes, Christian, Bacac, Marina

“…CEA TCB (RG7802, RO6958688) is a novel T-cell bispecific antibody, engaging CD3ε upon binding to carcinoembryonic antigen (CEA) on tumor cells. Containing an…”
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Aerosol Measurement: The Use of Optical Light Scattering for the Determination of Particulate Size Distribution, and Particulate Mass, Including the Semi-Volatile Fraction by Grimm, Hans, Eatough, Delbert J

“…The GRIMM model 1.107 monitor is designed to measure particle size distribution and particulate mass based on a light scattering measurement of individual…”
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Subcutaneous Site-of-Absorption Study with the Monoclonal Antibody Tocilizumab in Minipigs: Administration Behind Ear Translates Best to Humans by Richter, Wolfgang F., Grimm, Hans-Peter, Gouy, Marie-Hélène, Søgaard, Susi, Kreuzer, Caroline, Wessels, Uwe, Draganov, Dragomir, Muenzer, Chris, Hoche, Tonio

“…Minipigs have been proposed as animal model to study the subcutaneous (SC) absorption of monoclonal antibodies (mAb), because they are more translatable to…”
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Pharmacokinetics of Paracetamol in Göttingen Minipigs: In Vivo Studies and Modeling to Elucidate Physiological Determinants of Absorption by Suenderhauf, Claudia, Tuffin, Gerald, Lorentsen, Helle, Grimm, Hans-Peter, Flament, Christophe, Parrott, Neil

“…ABSTRACT Purpose Onset and rate of gastric emptying are important determinants of drug absorption after oral dosing. Therefore, robust estimates of these…”
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Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model by POIRIER, Agnès, LAVE, Thierry, PORTMANN, Renée, BRUN, Marie-Elise, SENNER, Frank, KANSY, Manfred, GRIMM, Hans-Peter, FUNK, Christoph

“…The use of in vitro data for quantitative predictions of transporter-mediated elimination in vivo requires an accurate estimation of the transporter…”
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High-Resolution Assessment of Air Quality in Urban Areas—A Business Model Perspective by Schäfer, Klaus, Lande, Kristian, Grimm, Hans, Jenniskens, Guido, Gijsbers, Roel, Ziegler, Volker, Hank, Marcus, Budde, Matthias

“…The increasing availability of low-cost air quality sensors has led to novel sensing approaches. Distributed networks of low-cost sensors, together with data…”
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Quantification of IgG monoclonal antibody clearance in tissues by Eigenmann, Miro J, Fronton, Ludivine, Grimm, Hans Peter, Otteneder, Michael B, Krippendorff, Ben-Fillippo

“…Monoclonal antibodies are an important therapeutic entity, and knowledge of antibody pharmacokinetics has steadily increased over the years. Despite this…”
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Relaxation Processes in Room Temperature Ionic Liquids:  The Case of 1-Butyl-3-Methyl Imidazolium Hexafluorophosphate by Triolo, Alessandro, Russina, Olga, Hardacre, Christopher, Nieuwenhuyzen, Mark, Gonzalez, Miguel Angel, Grimm, Hans

“…A detailed investigation on the nature of the relaxation processes occurring in a typical room temperature ionic liquid (RTIL), namely, 1-butyl-3-methyl…”
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Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans by Grimm, Hans Peter, Schumacher, Vanessa, Schäfer, Martin, Imhof-Jung, Sabine, Freskgård, Per-Ola, Brady, Kevin, Hofmann, Carsten, Rüger, Petra, Schlothauer, Tilman, Göpfert, Ulrich, Hartl, Maximilian, Rottach, Sylvia, Zwick, Adrian, Seger, Shanon, Neff, Rachel, Niewoehner, Jens, Janssen, Niels

“…There are few treatments that slow neurodegeneration in Alzheimer's disease (AD), and while therapeutic antibodies are being investigated in clinical trials…”
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Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice by Richter, Wolfgang F, Christianson, Gregory J, Frances, Nicolas, Grimm, Hans Peter, Proetzel, Gabriele, Roopenian, Derry C

“…The neonatal Fc receptor (FcRn) has been demonstrated to contribute to a high bioavailability of monoclonal antibodies (mAbs). In this study, we explored the…”
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Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Prediction of Monoclonal Antibody Tumor Disposition by Bordeau, Brandon M, Polli, Joseph Ryan, Schweser, Ferdinand, Grimm, Hans Peter, Richter, Wolfgang F, Balthasar, Joseph P

“…The prediction of monoclonal antibody (mAb) disposition within solid tumors for individual patients is difficult due to inter-patient variability in tumor…”
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Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid by Eigenmann, Miro Julian, Karlsen, Tine Veronica, Wagner, Marek, Tenstad, Olav, Weinzierl, Tina, Fauti, Tanja, Grimm, Hans Peter, Skogstrand, Trude, Klein, Christian, Sam, Johannes, Umana, Pablo, Bacac, Marina, Wiig, Helge, Walz, Antje-Christine

“…The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding…”
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The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat by Tai, Leon M., Jacobsen, Helmut, Ozmen, Laurence, Flohr, Alexander, Jakob-Roetne, Roland, Caruso, Antonello, Grimm, Hans-Peter

“…Inhibition of the enzyme(s) that produce the Amyloid beta (Aβ) peptide, namely BACE and γ-secretase, is considered an attractive target for Alzheimer’s disease…”
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In silico exploration of amyloid‐related imaging abnormalities in the gantenerumab open‐label extension trials using a semi‐mechanistic model by Aldea, Roxana, Grimm, Hans Peter, Gieschke, Ronald, Hofmann, Carsten, Lott, Dominik, Bullain, Szofia, Delmar, Paul, Klein, Gregory, Lyons, Marco, Piazza, Fabrizio, Carare, Roxana O., Mazer, Norman A.

“…Introduction Amyloid‐related imaging abnormalities with edema/effusion (ARIA‐E) are commonly observed with anti‐amyloid therapies in Alzheimer's disease. We…”
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Learn–confirm in model‐informed drug development: Assessing an immunogenicity quantitative systems pharmacology platform by Franssen, Linnea C., Swat, Maciej J., Kierzek, Andrzej M., Rose, Rachel H., Graaf, Piet H., Grimm, Hans Peter

“…Immunogenicity against therapeutic proteins frequently causes attrition owing to its potential impact on pharmacokinetics, pharmacodynamics, efficacy, and…”
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Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration by Zheng, Yanan, Tesar, Devin B., Benincosa, Lisa, Birnböck, Herbert, Boswell, C. Andrew, Bumbaca, Daniela, Cowan, Kyra J, Danilenko, Dimitry M., Daugherty, Ann L., Fielder, Paul J., Grimm, Hans Peter, Joshi, Amita, Justies, Nicole, Kolaitis, Gerry, Lewin-Koh, Nicholas, Li, Jing, McVay, Sami, O'Mahony, Jennifer, Otteneder, Michael, Pantze, Michael, Putnam, Wendy S., Qiu, Zhihua J., Ruppel, Jane, Singer, Thomas, Stauch, Oliver, Theil, Frank-Peter, Visich, Jennifer, Yang, Jihong, Ying, Yong, Khawli, Leslie A., Richter, Wolfgang F.

“…Subcutaneous (SC) delivery is a common route of administration for therapeutic monoclonal antibodies (mAbs) with pharmacokinetic (PK)/pharmacodynamic (PD)…”
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Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys by Vexler, Vladimir, Yu, Li, Pamulapati, Chandrasena, Garrido, Rosario, Grimm, Hans Peter, Sriraman, Priya, Bohini, Sandhya, Schraeml, Michael, Singh, Usha, Brandt, Michael, Ries, Stefan, Ma, Han, Klumpp, Klaus, Ji, Changhua

“…CD81 is an essential receptor for hepatitis C virus (HCV). K21 is a novel high affinity anti-CD81 antibody with potent broad spectrum anti-HCV activity in…”
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The Effects of Interleukin-6 Signal Blockade on Immune System, Reproductive and Skeletal Development in Juvenile Mice by Sakurai, Takayuki, Takai, Ryo, Bürgin, Heinrich, Shioda, Akifumi, Sakamoto, Yuichiro, Amano, Jun, Grimm, Hans Peter, Richter, Wolfgang F., Higuchi, Yoshinobu, Chiba, Shuichi, Kawamura, Akinori, Suzuki, Masami, Müller, Lutz

“…Interleukin‐6 (IL‐6) is involved in the pathogenesis of multiple disorders, including juvenile autoimmune diseases. IL‐6 participates in a broad spectrum of…”
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Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy by Ribba, Benjamin, Boetsch, Christophe, Nayak, Tapan, Grimm, Hans Peter, Charo, Jehad, Evers, Stefan, Klein, Christian, Tessier, Jean, Charoin, Jean Eric, Phipps, Alex, Pisa, Pavel, Teichgräber, Volker

“…Optimal dosing is critical for immunocytokine-based cancer immunotherapy to maximize efficacy and minimize toxicity. Cergutuzumab amunaleukin (CEA-IL2v) is a…”
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Gaining insights into the consequences of target-mediated drug disposition of monoclonal antibodies using quasi-steady-state approximations by Grimm, Hans Peter

“…Target-mediated drug disposition (TMDD) is frequently reported for therapeutic monoclonal antibodies and is linked to the high affinity and high specificity of…”
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