Search Results - "Grimm, Christina"

MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments by Lienhard, Matthias, Grimm, Christina, Morkel, Markus, Herwig, Ralf, Chavez, Lukas

“…DNA enrichment followed by sequencing is a versatile tool in molecular biology, with a wide variety of applications including genome-wide analysis of…”
Get full text

Deep learning-based behavioral analysis reaches human accuracy and is capable of outperforming commercial solutions by Sturman, Oliver, von Ziegler, Lukas, Schläppi, Christa, Akyol, Furkan, Privitera, Mattia, Slominski, Daria, Grimm, Christina, Thieren, Laetitia, Zerbi, Valerio, Grewe, Benjamin, Bohacek, Johannes

“…To study brain function, preclinical research heavily relies on animal monitoring and the subsequent analyses of behavior. Commercial platforms have enabled…”
Get full text

Emerging imaging methods to study whole-brain function in rodent models by Markicevic, Marija, Savvateev, Iurii, Grimm, Christina, Zerbi, Valerio

“…In the past decade, the idea that single populations of neurons support cognition and behavior has gradually given way to the realization that connectivity…”
Get full text

Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage by Chavez, Lukas, Jozefczuk, Justyna, Grimm, Christina, Dietrich, Jörn, Timmermann, Bernd, Lehrach, Hans, Herwig, Ralf, Adjaye, James

“…The generation of genome-wide data derived from methylated DNA immunoprecipitation followed by sequencing (MeDIP-seq) has become a major tool for epigenetic…”
Get full text

The bromodomain protein BRD4 regulates splicing during heat shock by Hussong, Michelle, Kaehler, Christian, Kerick, Martin, Grimm, Christina, Franz, Alexandra, Timmermann, Bernd, Welzel, Franziska, Isensee, Jörg, Hucho, Tim, Krobitsch, Sylvia, Schweiger, Michal R

“…The cellular response to heat stress is an ancient and evolutionarily highly conserved defence mechanism characterised by the transcriptional up-regulation of…”
Get full text

Optogenetic activation of striatal D1R and D2R cells differentially engages downstream connected areas beyond the basal ganglia by Grimm, Christina, Frässle, Stefan, Steger, Céline, von Ziegler, Lukas, Sturman, Oliver, Shemesh, Noam, Peleg-Raibstein, Daria, Burdakov, Denis, Bohacek, Johannes, Stephan, Klaas Enno, Razansky, Daniel, Wenderoth, Nicole, Zerbi, Valerio

“…The basal ganglia (BG) are a group of subcortical nuclei responsible for motor and executive function. Central to BG function are striatal cells expressing D1…”
Get full text

Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity by Grimm, Christina M., Aksamaz, Sonat, Schulz, Stefanie, Teutsch, Jasper, Sicinski, Piotr, Liss, Birgit, Kätzel, Dennis

“…Elevated activity at the output stage of the anterior hippocampus has been described as a physiological endophenotype of schizophrenia, and its development…”
Get full text

MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy by Jung, Monika, Mollenkopf, Hans‐Joachim, Grimm, Christina, Wagner, Ina, Albrecht, Marco, Waller, Tobias, Pilarsky, Christian, Johannsen, Manfred, Stephan, Carsten, Lehrach, Hans, Nietfeld, Wilfried, Rudel, Thomas, Jung, Klaus, Kristiansen, Glen

“…MicroRNAs are short single‐stranded RNAs that are associated with gene regulation at the transcriptional and translational level. Changes in their expression…”
Get full text

An optimized protocol for assessing changes in mouse whole-brain activity using opto-fMRI by Grimm, Christina, Wenderoth, Nicole, Zerbi, Valerio

“…Functional magnetic resonance imaging (fMRI) in mouse brain, paired with spatially and temporally defined manipulations, offers a powerful tool to causally…”
Get full text

Acute optogenetic induction of the prodromal endophenotype of CA1 hyperactivity causes schizophrenia-related deficits in cognition and salience attribution by Kapanaiah, Sampath K. T., Grimm, Christina, Kätzel, Dennis

“…Hyperactivity of the human anterior hippocampus has been reported to spread from its CA1 subfield to the subiculum around the onset of first-episode psychosis…”
Get full text

Variant profiling of colorectal adenomas from three patients of two families with MSH3-related adenomatous polyposis by Perne, Claudia, Peters, Sophia, Cartolano, Maria, Horpaopan, Sukanya, Grimm, Christina, Altmüller, Janine, Sommer, Anna K, Hillmer, Axel M, Thiele, Holger, Odenthal, Margarete, Möslein, Gabriela, Adam, Ronja, Sivalingam, Sugirthan, Kirfel, Jutta, Schweiger, Michal R, Peifer, Martin, Spier, Isabel, Aretz, Stefan

“…The spectrum of somatic genetic variation in colorectal adenomas caused by biallelic pathogenic germline variants in the MSH3 gene, was comprehensively…”
Get full text

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex by Lange, Martin, Kaynak, Bogac, Forster, Ulrike B, Tönjes, Martje, Fischer, Jenny J, Grimm, Christina, Schlesinger, Jenny, Just, Steffen, Dunkel, Ilona, Krueger, Tammo, Mebus, Siegrun, Lehrach, Hans, Lurz, Rudi, Gobom, Johan, Rottbauer, Wolfgang, Abdelilah-Seyfried, Salim, Sperling, Silke

“…Chromatin remodeling and histone modifications facilitate access of transcription factors to DNA by promoting the unwinding and destabilization of histone-DNA…”
Get full text

A tunable strain sensor using nanogranular metals by Schwalb, Christian H, Grimm, Christina, Baranowski, Markus, Sachser, Roland, Porrati, Fabrizio, Reith, Heiko, Das, Pintu, Müller, Jens, Völklein, Friedemann, Kaya, Alexander, Huth, Michael

“…This paper introduces a new methodology for the fabrication of strain-sensor elements for MEMS and NEMS applications based on the tunneling effect in…”
Get full text

Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients by Pacholewska, Alicja, Grimm, Christina, Herling, Carmen D., Lienhard, Matthias, Königs, Anja, Timmermann, Bernd, Altmüller, Janine, Mücke, Oliver, Reinhardt, Hans Christian, Plass, Christoph, Herwig, Ralf, Hallek, Michael, Schweiger, Michal R.

“…Mutations in splicing factor genes have a severe impact on the survival of cancer patients. Splicing factor 3b subunit 1 (SF3B1) is one of the most frequently…”
Get full text

Pericentromeric Satellite III transcripts induce etoposide resistance by Kanne, Julian, Hussong, Michelle, Isensee, Jörg, Muñoz-López, Álvaro, Wolffgramm, Jan, Heß, Felix, Grimm, Christina, Bessonov, Sergey, Meder, Lydia, Wang, Jie, Reinhardt, H. Christian, Odenthal, Margarete, Hucho, Tim, Büttner, Reinhard, Summerer, Daniel, Schweiger, Michal R.

“…Non-coding RNA from pericentromeric satellite repeats are involved in stress-dependent splicing processes, maintenance of heterochromatin, and are required to…”
Get full text

Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance by Grasse, Sabrina, Lienhard, Matthias, Frese, Steffen, Kerick, Martin, Steinbach, Anne, Grimm, Christina, Hussong, Michelle, Rolff, Jana, Becker, Michael, Dreher, Felix, Schirmer, Uwe, Boerno, Stefan, Ramisch, Anna, Leschber, Gunda, Timmermann, Bernd, Grohé, Christian, Lüders, Heike, Vingron, Martin, Fichtner, Iduna, Klein, Sebastian, Odenthal, Margarete, Büttner, Reinhard, Lehrach, Hans, Sültmann, Holger, Herwig, Ralf, Schweiger, Michal R

“…Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related deaths worldwide and is primarily treated with radiation, surgery, and…”
Get full text

Wnt and BMP signals control intestinal adenoma cell fates by Farrall, Alexandra L., Riemer, Pamela, Leushacke, Marc, Sreekumar, Amulya, Grimm, Christina, Herrmann, Bernhard G., Morkel, Markus

“…Cellular hierarchies and signals that govern stemness and differentiation of intestinal adenoma cells are not well defined. In this study, we used organotypic…”
Get full text

Evaluation of a Prognostic Epigenetic Classification System in Chronic Lymphocytic Leukemia Patients by Grimm, Christina, Herling, Carmen Diana, Komnidi, Anastasia, Hussong, Michelle, Kreuzer, Karl-Anton, Hallek, Michael, Schweiger, Michal R.

“…Background: Methylation at 5 CpG sites was previously shown to classify chronic lymphocytic leukemia (CLL) into 3 prognostic subgroups. Here, we aimed to…”
Get full text

DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer by Grimm, Christina, Chavez, Lukas, Vilardell, Mireia, Farrall, Alexandra L, Tierling, Sascha, Böhm, Julia W, Grote, Phillip, Lienhard, Matthias, Dietrich, Jörn, Timmermann, Bernd, Walter, Jörn, Schweiger, Michal R, Lehrach, Hans, Herwig, Ralf, Herrmann, Bernhard G, Morkel, Markus

“…Aberrant CpG methylation is a universal epigenetic trait of cancer cell genomes. However, human cancer samples or cell lines preclude the investigation of…”
Get full text

Characterization of TBX20 in human hearts and its regulation by TFAP2 by Hammer, Stefanie, Toenjes, Martje, Lange, Martin, Fischer, Jenny J., Dunkel, Ilona, Mebus, Siegrun, Grimm, Christina H., Hetzer, Roland, Berger, Felix, Sperling, Silke

“…The T‐box family of transcription factors has been shown to have major impact on human development and disease. In animal studies Tbx20 is essential for the…”
Get full text