Search Results - "Grimm, C. C"

Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis by Rosato, A. Scotto, Tang, R., Grimm, C.

“…The old Greek saying “Panta Rhei” (“everything flows”) is true for all life and all living things in general. It also becomes nicely evident when looking…”
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TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway by Scotto Rosato, A., Montefusco, S., Soldati, C., Di Paola, S., Capuozzo, A., Monfregola, J., Polishchuk, E., Amabile, A., Grimm, C., Lombardo, A., De Matteis, M. A., Ballabio, A., Medina, D. L.

“…The lysosomal calcium channel TRPML1, whose mutations cause the lysosomal storage disorder (LSD) mucolipidosis type IV (MLIV), contributes to upregulate…”
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Holocene Vegetation and Climate Dynamics in the Altai Mountains and Surrounding Areas by Huang, Xiaozhong, Peng, Wei, Rudaya, Natalia, Grimm, Eric C., Chen, Xuemei, Cao, Xianyong, Zhang, Jun, Pan, Xiaoduo, Liu, Sisi, Chen, Chunzhu, Chen, Fahu

“…A comprehensive understanding of the regional vegetation responses to long‐term climate change will help to forecast Earth system dynamics. Based on a new…”
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Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors by Metze, S., Ruhl, S., Greller, G., Grimm, C., Scholz, J.

“…In 2004, the FDA published a guideline to implement process analytical technologies (PAT) in biopharmaceutical processes for process monitoring to gain process…”
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Long-term outcomes of aortic root operations for Marfan syndrome: A comparison of Bentall versus aortic valve-sparing procedures by Price, Joel, MD, MPH, Magruder, J. Trent, MD, Young, Allen, MPH, Grimm, Joshua C., MD, Patel, Nishant D., MD, Alejo, Diane, BA, Dietz, Harry C., MD, Vricella, Luca A., MD, Cameron, Duke E., MD

“…Abstract Objectives Prophylactic aortic root replacement improves survival in patients with Marfan syndrome with aortic root aneurysms, but the optimal…”
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Transcriptomic analysis of the mouse retina after acute and chronic normobaric and hypobaric hypoxia by Ebner, L. J. A., Samardzija, M., Storti, F., Todorova, V., Karademir, D., Behr, J., Simpson, F., Thiersch, M., Grimm, C.

“…Oxygen delivery to the retinal pigment epithelium and the outer retina is essential for metabolism, function, and survival of photoreceptors. Chronically…”
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Blue light-induced retinal lesions, intraretinal vascular leakage and edema formation in the all-cone mouse retina by Geiger, P, Barben, M, Grimm, C, Samardzija, M

“…Little is known about the mechanisms underlying macular degenerations, mainly for the scarcity of adequate experimental models to investigate cone cell death…”
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A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration by Tavakoli, P, Vollmer-Conna, U, Hadzi-Pavlovic, D, Grimm, M C

“…Inflammatory bowel diseases (IBDs) are complex chronic inflammatory disorders of the gastro-intestinal (GI) tract with uncertain etiology. IBDs comprise two…”
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TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells by Wünkhaus, D., Tang, R., Nyame, K., Laqtom, N. N., Schweizer, M., Scotto Rosato, A., Krogsæter, E. K., Wollnik, C., Abu-Remaileh, M., Grimm, C., Hermey, G., Kuhn, R., Gruber-Schoffnegger, D., Markmann, S.

“…Mutations in the lysosomal membrane protein CLN3 cause Juvenile Neuronal Ceroid Lipofuscinosis (JNCL). Activation of the lysosomal ion channel TRPML1 has…”
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Vicilin and legumin storage proteins are abundant in water and alkali soluble protein fractions of glandless cottonseed by He, Zhongqi, Mattison, Christopher P., Zhang, Dunhua, Grimm, Casey C.

“…In this work, we sequentially extracted water (CSPw)- and alkali (CSPa)-soluble protein fractions from glandless cottonseed. SDS-Gel electrophoresis separated…”
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Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies by Thomalla, D., Beckmann, L., Grimm, C., Oliverio, M., Meder, L., Herling, C.D., Nieper, P., Feldmann, T., Merkel, O., Lorsy, E., da Palma Guerreiro, A., von Jan, J., Kisis, I., Wasserburger, E., Claasen, J., Faitschuk-Meyer, E., Altmüller, J., Nürnberg, P., Yang, T.-P., Lienhard, M., Herwig, R., Kreuzer, K.-A., Pallasch, C.P., Büttner, R., Schäfer, S.C., Hartley, J., Abken, H., Peifer, M., Kashkar, H., Knittel, G., Eichhorst, B., Ullrich, R.T., Herling, M., Reinhardt, H.C., Hallek, M., Schweiger, M.R., Frenzel, L.P.

“…•Venetoclax resistance is mediated by methylation and silencing of PUMA.•Treatment algorithms should consider the PUMA, MCL1, and BAX status. [Display omitted]…”
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Bilateral Internal Thoracic Artery Grafting: Does Graft Configuration Affect Outcome? by Magruder, J. Trent, M.D, Young, Allen, B.A, Grimm, Joshua C., M.D, Conte, John V., M.D, Shah, Ashish S., M.D, Mandal, Kaushik, M.D, Sciortino, Christopher M., M.D., Ph.D, Zehr, Kenton J., M.D, Cameron, Duke E., M.D, Price, Joel, M.D., M.P.H

“…Structured abstract Background Despite evidence that bilateral internal thoracic arteries (ITAs) improve long-term survival after coronary artery bypass…”
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Morphometric and Visual Evaluation of Fibrosis in Renal Biopsies by FARRIS, Alton B, ADAMS, Catherine D, BROUSAIDES, Nicole, DELLA PELLE, Patricia A, BERNARD COLLINS, A, MORADI, Ellie, SMITH, R. Neal, GRIMM, Paul C, COLVIN, Robert B

“…Interstitial fibrosis is an outcome measure of increasing importance in clinical trials of both renal transplantation and native disease, but data on the…”
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Global-scale multidecadal variability missing in state-of-the-art climate models by Kravtsov, S., Grimm, C., Gu, S.

“…Reliability of future global warming projections depends on how well climate models reproduce the observed climate change over the twentieth century. In this…”
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Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations by Sandor, M., Rüdinger, F., Bienert, R., Grimm, C., Solle, D., Scheper, T.

“…•Establishing a bench mark CHO cultivation to test spectrometers.•Monitoring several parameters inline by infrared spectroscopy.•Near infrared for monitoring…”
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Rates and predictors of readmission after minor lower extremity amputations by Beaulieu, Robert J., MD, Grimm, Joshua C., MD, Lyu, Heather, MD, Abularrage, Christopher J., MD, Perler, Bruce A., MD, MBA

“…Objective One goal of the Patient Protection and Affordable Care Act is to reduce hospital readmissions, with financial penalties applied for excessive rates…”
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Empathy as a function of clinical exposure--reading emotion in the eyes by Handford, Cameron, Lemon, Jim, Grimm, Michael C, Vollmer-Conna, Ute

“…Evidence based largely on self-report data suggests that factors associated with medical education erode the critical human quality of empathy. These reports…”
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A pilot goal-directed perfusion initiative is associated with less acute kidney injury after cardiac surgery by Magruder, J. Trent, MD, Crawford, Todd C., MD, Harness, Herbert Lynn, CCP, LP, Grimm, Joshua C., MD, Suarez-Pierre, Alejandro, MD, Wierschke, Chad, CCP, LP, Biewer, Jim, CCP, LP, Hogue, Charles, MD, Whitman, Glenn R., MD, Shah, Ashish S., MD, Barodka, Viachaslau, MD

“…Abstract Background We sought to determine whether a pilot goal-directed perfusion initiative could reduce the incidence of acute kidney injury after cardiac…”
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Evaluation of the practice of reprocessing ORs in German hospitals from an infection prevention and control perspective by Grimm, C, Scheithauer, S, Artelt, T, Stieber, A, Erlenwein, J, Schuster, M, Bauer, M, Waeschle, Reiner M.

“…Background The aim of this study was to analyze the cleaning and disinfection of operating rooms (ORs) status quo focusing on hygiene plans in German…”
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Influence of Sodium Glucose Cotransporter 2 Inhibition on Physiological Adaptation to Endurance Exercise Training by Newman, Alissa A, Grimm, Nathan C, Wilburn, Jessie R, Schoenberg, Hayden M, Trikha, S Raj J, Luckasen, Gary J, Biela, Laurie M, Melby, Christopher L, Bell, Christopher

“…Abstract Context The combination of two beneficial antidiabetes interventions, regular exercise and pharmaceuticals, is intuitively appealing. However,…”
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