Search Results - "Grimm, Amandine"

Brain aging and neurodegeneration: from a mitochondrial point of view by Grimm, Amandine, Eckert, Anne

“…Aging is defined as a progressive time‐related accumulation of changes responsible for or at least involved in the increased susceptibility to disease and…”
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Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation? by Grimm, Amandine

“…The brain is the most energy-consuming organ of the body and impairments in brain energy metabolism will affect neuronal functionality and viability. Brain…”
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Insights into Disease-Associated Tau Impact on Mitochondria by Szabo, Leonora, Eckert, Anne, Grimm, Amandine

“…Abnormal tau protein aggregation in the brain is a hallmark of tauopathies, such as frontotemporal lobar degeneration and Alzheimer's disease. Substantial…”
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Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease by Grimm, Amandine, Friedland, Kristina, Eckert, Anne

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disease that represents the most common form of dementia among the elderly. Despite the fact that…”
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Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence by Eckert, Anne, Grimm, Amandine, Agapouda, Anastasia, Lejri, Imane

“…Alzheimer’s disease (AD) is the most common form of dementia affecting people mainly in their sixth decade of life and at a higher age. It is an extensively…”
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Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics by Schmitt, Karen, Grimm, Amandine, Dallmann, Robert, Oettinghaus, Bjoern, Restelli, Lisa Michelle, Witzig, Melissa, Ishihara, Naotada, Mihara, Katsuyoshi, Ripperger, Jürgen A., Albrecht, Urs, Frank, Stephan, Brown, Steven A., Eckert, Anne

“…Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative phosphorylation and generation of ATP, are strongly…”
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Mitochondria, Estrogen and Female Brain Aging by Lejri, Imane, Grimm, Amandine, Eckert, Anne

“…Mitochondria play an essential role in the generation of steroid hormones including the female sex hormones. These hormones are, in turn, able to modulate…”
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Ginkgo biloba extract increases neurite outgrowth and activates the Akt/mTOR pathway by Lejri, Imane, Grimm, Amandine, Eckert, Anne

“…Standardized Ginkgo biloba extract (GBE) has demonstrated efficacy in the cognitive functional neuropsychiatric symptoms of patients with Alzheimer's disease…”
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Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein by Fairley, Lauren H, Lejri, Imane, Grimm, Amandine, Eckert, Anne

“…Abnormal tau build-up is a hallmark of Alzheimer's disease (AD) and more than 20 other serious neurodegenerative diseases. Mitochondria are paramount…”
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Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging? by Varghese, Nimmy, Werner, Selina, Grimm, Amandine, Eckert, Anne

“…Recently, nutritional interventions have received attention as promising approaches to promote human health during a lifespan. The Mediterranean and Okinawan…”
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Mitochondria Transfer in Brain Injury and Disease by Fairley, Lauren H, Grimm, Amandine, Eckert, Anne

“…Intercellular mitochondria transfer is a novel form of cell signalling in which whole mitochondria are transferred between cells in order to enhance cellular…”
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Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies by Grimm, Amandine, Lejri, Imane, Hallé, François, Schmitt, Martine, Götz, Jürgen, Bihel, Frederic, Eckert, Anne

“…Translocator protein 18 kDa (TSPO) is a mitochondrial protein located in the outer membrane and involved in cholesterol translocation, a prerequisite for…”
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TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis by Lejri, Imane, Grimm, Amandine, Hallé, François, Abarghaz, Mustapha, Klein, Christian, Maitre, Michel, Schmitt, Martine, Bourguignon, Jean-Jacques, Mensah-Nyagan, Ayikoe Guy, Bihel, Frederic, Eckert, Anne

“…Translocator protein 18 kDa (TSPO) is located in the mitochondrial outer membrane and plays an important role in steroidogenesis and cell survival. In the…”
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From Young to Old: Mimicking Neuronal Aging in Directly Converted Neurons from Young Donors by Varghese, Nimmy, Grimm, Amandine, Cader, M Zameel, Eckert, Anne

“…A substantial challenge in human brain aging is to find a suitable model to mimic neuronal aging in vitro as accurately as possible. Using directly converted…”
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Local Oxidative Damage in the Soma and Dendrites Quarantines Neuronal Mitochondria at the Site of Insult by Grimm, Amandine, Cummins, Nadia, Götz, Jürgen

“…Neurons are highly dependent on mitochondria, but little is known about how they react to a local mitochondrial oxidative insult. We therefore developed a…”
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Transmission-selective muscle pathology induced by the active propagation of mutant huntingtin across the human neuromuscular synapse by Dinamarca, Margarita C, Colombo, Laura, Brykczynska, Urszula, Grimm, Amandine, Fruh, Isabelle, Hossain, Imtiaz, Gabriel, Daniela, Eckert, Anne, Müller, Matthias, Pecho-Vrieseling, Eline

“…Neuron-to-neuron transmission of aggregation-prone, misfolded proteins may potentially explain the spatiotemporal accumulation of pathological lesions in the…”
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Genetically Engineered Triple MAPT -Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics by Szabo, Leonora, Grimm, Amandine, García-León, Juan Antonio, Verfaillie, Catherine M, Eckert, Anne

“…Pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. Several tau mutations have…”
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Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice by Moore, James, Akbergenov, Rashid, Nigri, Martina, Isnard-Petit, Patricia, Grimm, Amandine, Seebeck, Petra, Restelli, Lisa, Frank, Stephan, Eckert, Anne, Thiam, Kader, Wolfer, David P., Shcherbakov, Dimitri, Böttger, Erik C.

“…Random errors in protein synthesis are prevalent and ubiquitous, yet their effect on organismal health has remained enigmatic for over five decades. Here, we…”
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Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol by Lim, Yun-An, Grimm, Amandine, Giese, Maria, Mensah-Nyagan, Ayikoe Guy, Villafranca, J Ernest, Ittner, Lars M, Eckert, Anne, Götz, Jürgen

“…Alzheimer's disease (AD) is a conformational disease that is characterized by amyloid-β (Aβ) deposition in the brain. Aβ exerts its toxicity in part by…”
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Silencing of the ER and Integrative Stress Responses in the Liver of Mice with Error-Prone Translation by Moore, James, Osinnii, Ivan, Grimm, Amandine, Oettinghaus, Björn, Eckert, Anne, Frank, Stephan, Böttger, Erik C

“…Translational errors frequently arise during protein synthesis, producing misfolded and dysfunctional proteins. Chronic stress resulting from translation…”
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