Search Results - "Grimes, H"

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice by Olsson, Andre, Venkatasubramanian, Meenakshi, Chaudhri, Viren K., Aronow, Bruce J., Salomonis, Nathan, Singh, Harinder, Grimes, H. Leighton

“…Stem cells generate progenitors that transition through a series of dynamically unstable states with mixed-lineage gene expression, culminating in the…”
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Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes by Yáñez, Alberto, Coetzee, Simon G., Olsson, Andre, Muench, David E., Berman, Benjamin P., Hazelett, Dennis J., Salomonis, Nathan, Grimes, H. Leighton, Goodridge, Helen S.

“…Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs) produce monocytes during homeostasis and in response to increased demand…”
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pyInfinityFlow: optimized imputation and analysis of high-dimensional flow cytometry data for millions of cells by Ferchen, Kyle, Salomonis, Nathan, Grimes, H Leighton

“…Abstract Motivation While conventional flow cytometry is limited to dozens of markers, new experimental and computational strategies, such as Infinity Flow,…”
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The Human Cell Atlas bone marrow single-cell interactive web portal by Hay, Stuart B., Ferchen, Kyle, Chetal, Kashish, Grimes, H. Leighton, Salomonis, Nathan

“…•Interactive resource for bone marrow donor variation between cell populations.•Deep evaluation of Human Cell Atlas (HCA) data spanning eight donors and…”
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Unraveling bone marrow architecture by Lucas, Daniel, Salomonis, Nathan, Grimes, H. Leighton

“…Different types of stromal cells in the bone marrow associate to form niches that support differentiating blood cells and ensure lifelong production of all…”
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Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition by Hinge, Ashwini, He, Jingyi, Bartram, James, Javier, Jose, Xu, Juying, Fjellman, Ellen, Sesaki, Hiromi, Li, Tingyu, Yu, Jie, Wunderlich, Mark, Mulloy, James, Kofron, Matthew, Salomonis, Nathan, Grimes, H. Leighton, Filippi, Marie-Dominique

“…The metabolic requirements of hematopoietic stem cells (HSCs) change with their cell cycle activity. However, the underlying role of mitochondria remains…”
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cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes by DePasquale, Erica A K, Schnell, Daniel, Dexheimer, Phillip, Ferchen, Kyle, Hay, Stuart, Chetal, Kashish, Valiente-Alandí, Íñigo, Blaxall, Burns C, Grimes, H Leighton, Salomonis, Nathan

“…Abstract To understand the molecular pathogenesis of human disease, precision analyses to define alterations within and between disease-associated cell…”
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DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data by DePasquale, Erica A.K., Schnell, Daniel J., Van Camp, Pieter-Jan, Valiente-Alandí, Íñigo, Blaxall, Burns C., Grimes, H. Leighton, Singh, Harinder, Salomonis, Nathan

“…Methods for single-cell RNA sequencing (scRNA-seq) have greatly advanced in recent years. While droplet- and well-based methods have increased the capture…”
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Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor by Kwok, Immanuel, Becht, Etienne, Xia, Yu, Ng, Melissa, Teh, Ye Chean, Tan, Leonard, Evrard, Maximilien, Li, Jackson L.Y., Tran, Hoa T.N., Tan, Yingrou, Liu, Dehua, Mishra, Archita, Liong, Ka Hang, Leong, Keith, Zhang, Yuning, Olsson, Andre, Mantri, Chinmay Kumar, Shyamsunder, Pavithra, Liu, Zhaoyuan, Piot, Cecile, Dutertre, Charles-Antoine, Cheng, Hui, Bari, Sudipto, Ang, Nicholas, Biswas, Subhra K., Koeffler, H. Philip, Tey, Hong Liang, Larbi, Anis, Su, I-Hsin, Lee, Bernett, St. John, Ashley, Chan, Jerry K.Y., Hwang, William Y.K., Chen, Jinmiao, Salomonis, Nathan, Chong, Shu Zhen, Grimes, H. Leighton, Liu, Bing, Hidalgo, Andrés, Newell, Evan W., Cheng, Tao, Ginhoux, Florent, Ng, Lai Guan

“…Granulocyte-monocyte progenitors (GMPs) have been previously defined for their potential to generate various myeloid progenies such as neutrophils and…”
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Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression by Lee, Jung-Mi, Govindarajah, Vinothini, Goddard, Bryan, Hinge, Ashwini, Muench, David E, Filippi, Marie-Dominique, Aronow, Bruce, Cancelas, Jose A, Salomonis, Nathan, Grimes, H Leighton, Reynaud, Damien

“…Obesity is a chronic organismal stress that disrupts multiple systemic and tissue-specific functions. In this study, we describe the impact of obesity on the…”
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Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma by Lee, Catherine, Rudneva, Vasilisa A., Erkek, Serap, Zapatka, Marc, Chau, Lianne Q., Tacheva-Grigorova, Silvia K., Garancher, Alexandra, Rusert, Jessica M., Aksoy, Ozlem, Lea, Robin, Mohammad, Helai P., Wang, Jianxun, Weiss, William A., Grimes, H. Leighton, Pfister, Stefan M., Northcott, Paul A., Wechsler-Reya, Robert J.

“…Drugs that modify the epigenome are powerful tools for treating cancer, but these drugs often have pleiotropic effects, and identifying patients who will…”
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MAPK-negative feedback regulation confers dependence to JAK2V617F signaling by Kesarwani, Meenu, Kincaid, Zachary, Azhar, Mohammad, Menke, Jacob, Schwieterman, Joshua, Ansari, Sekhu, Reaves, Angela, Deininger, Michael E., Levine, Ross, Grimes, H. Leighton, Azam, Mohammad

“…Despite significant advances in developing selective JAK2 inhibitors, JAK2 kinase inhibitor (TKI) therapy is ineffective in suppressing the disease…”
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A primer on single-cell genomics in myeloid biology by Ferchen, Kyle, Song, Baobao, Leighton Grimes, H.

“…PURPOSE OF REVIEWUnderstanding the fast-moving field of single-cell technologies, as applied to myeloid biology, requires an appreciation of basic molecular,…”
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The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification by Lu, Yi-Chien, Sanada, Chad, Xavier-Ferrucio, Juliana, Wang, Lin, Zhang, Ping-Xia, Grimes, H. Leighton, Venkatasubramanian, Meenakshi, Chetal, Kashish, Aronow, Bruce, Salomonis, Nathan, Krause, Diane S.

“…Megakaryocytic-erythroid progenitors (MEPs) give rise to the cells that produce red blood cells and platelets. Although the mechanisms underlying…”
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Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia by Adelman, Emmalee R, Huang, Hsuan-Ting, Roisman, Alejandro, Olsson, André, Colaprico, Antonio, Qin, Tingting, Lindsley, R Coleman, Bejar, Rafael, Salomonis, Nathan, Grimes, H Leighton, Figueroa, Maria E

“…Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative…”
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Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia by Kesarwani, Meenu, Kincaid, Zachary, Gomaa, Ahmed, Huber, Erika, Rohrabaugh, Sara, Siddiqui, Zain, Bouso, Muhammad F, Latif, Tahir, Xu, Ming, Komurov, Kakajan, Mulloy, James C, Cancelas, Jose A, Grimes, H Leighton, Azam, Mohammad

“…The intrinsic resistance of BCR-ABL-expressing chronic myeloid leukemia stem cells to treatment with tyrosine-kinase inhibitors requires growth-factor…”
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Decision level integration of unimodal and multimodal single cell data with scTriangulate by Li, Guangyuan, Song, Baobao, Singh, Harinder, Surya Prasath, V. B., Leighton Grimes, H., Salomonis, Nathan

“…Decisively delineating cell identities from uni- and multimodal single-cell datasets is complicated by diverse modalities, clustering methods, and reference…”
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Improved detection of measurable residual disease in acute myeloid leukemia by Zhang, Xuan, Grimes, H. Leighton

“…A novel multiplex single-cell genomic and immunophenotypic strategy leverages the sensitivity of MRD detection and distinguishes leukemic and preleukemic…”
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Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress by Unnisa, Zeenath, Clark, Jason P., Roychoudhury, Jayeeta, Thomas, Elizabeth, Tessarollo, Lino, Copeland, Neal G., Jenkins, Nancy A., Grimes, H. Leighton, Kumar, Ashish R.

“…The transcription factor Meis1 is expressed preferentially in hematopoietic stem cells (HSCs) and overexpressed in certain leukemias. However, the functions of…”
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Gestational diabetes in mice induces hematopoietic memory that affects the long-term health of the offspring by Govindarajah, Vinothini, Sakabe, Masahide, Good, Samantha, Solomon, Michael, Arasu, Ashok, Chen, Nong, Zhang, Xuan, Grimes, H Leighton, Kendler, Ady, Xin, Mei, Reynaud, Damien

“…Gestational diabetes is a common medical complication of pregnancy that is associated with adverse perinatal outcomes and an increased risk of metabolic…”
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