Search Results - "Grimes, Brenda"

A real-world US study of recurrence risks using combined clinicopathological features in HR-positive, HER2-negative early breast cancer by Sheffield, Kristin M, Peachey, Jessica R, Method, Michael, Grimes, Brenda R, Brown, Jacqueline, Saverno, Kim, Sugihara, Tomoko, Cui, Zhanglin Lin, Lee, Kimberley T

“…To assess invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS) in hormone receptor-positive, HER2-negative early breast cancer with…”
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Adjuvant Abemaciclib Combined with Endocrine Therapy: Efficacy Results in monarchE Cohort 1 by Toi, Masakazu, Boyle, Frances, Im, Young-Hyuck, Reinisch, Mattea, Molthrop, David, Jiang, Zefei, Wei, Ran, Sapunar, Francisco, Grimes, Brenda R, Nabinger, Sarah Cassidy, Johnston, Stephen R D

“…The monarchE Cohort 1 patient population was enrolled based on high-risk clinicopathological features that can easily be identified as part of routine clinical…”
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A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function by Kononenko, Artem V, Bansal, Ruchi, Lee, Nicholas C O, Grimes, Brenda R, Masumoto, Hiroshi, Earnshaw, William C, Larionov, Vladimir, Kouprina, Natalay

“…BRCA1 is involved in many disparate cellular functions, including DNA damage repair, cell-cycle checkpoint activation, gene transcriptional regulation, DNA…”
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Telomere fusions in early human breast carcinoma by Tanaka, Hiromi, Abe, Satoshi, Huda, Nazmul, Tu, LiRen, Beam, Matthew J, Grimes, Brenda, Gilley, David

“…Several lines of evidence suggest that defects in telomere maintenance play a significant role in the initiation of genomic instability during carcinogenesis…”
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Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715 by Slee, Roger B, Grimes, Brenda R, Bansal, Ruchi, Gore, Jesse, Blackburn, Corinne, Brown, Lyndsey, Gasaway, Rachel, Jeong, Jaesik, Victorino, Jose, March, Keith L, Colombo, Riccardo, Herbert, Brittney-Shea, Korc, Murray

“…Most solid tumors, including pancreatic ductal adenocarcinoma (PDAC), exhibit structural and numerical chromosome instability (CIN). Although often implicated…”
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Widespread telomere instability in prostatic lesions by Tu, LiRen, Huda, Nazmul, Grimes, Brenda R., Slee, Roger B., Bates, Alison M., Cheng, Liang, Gilley, David

“…A critical function of the telomere is to disguise chromosome ends from cellular recognition as double strand breaks, thereby preventing aberrant chromosome…”
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A telomerase immortalized human proximal tubule cell line with a truncation mutation (Q4004X) in polycystin-1 by Herbert, Brittney-Shea, Grimes, Brenda R, Xu, Wei Min, Werner, Michael, Ward, Christopher, Rossetti, Sandro, Harris, Peter, Bello-Reuss, Elsa, Ward, Heather H, Miller, Caroline, Gattone, 2nd, Vincent H, Phillips, Carrie L, Wandinger-Ness, Angela, Bacallao, Robert L

“…Autosomal dominant polycystic kidney disease (ADPKD) is associated with a variety of cellular phenotypes in renal epithelial cells. Cystic epithelia are…”
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Human umbilical cord blood plasma can replace fetal bovine serum for in vitro expansion of functional human endothelial colony-forming cells by Huang, Lan, Critser, Paul J, Grimes, Brenda R, Yoder, Mervin C

“…Abstract Background aims A hierarchy of endothelial colony-forming cells (ECFC) with different levels of proliferative potential has been identified in human…”
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A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells by Lee, Hee-Sheung, Lee, Nicholas C O, Grimes, Brenda R, Samoshkin, Alexander, Kononenko, Artem V, Bansal, Ruchi, Masumoto, Hiroshi, Earnshaw, William C, Kouprina, Natalay, Larionov, Vladimir

“…Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN)…”
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Construction of YAC-based mammalian artificial chromosomes by Ikeno, Masashi, Grimes, Brenda, Okazaki, Tuneko, Nakano, Megumi, Saitoh, Kaori, Hoshino, Harumi, McGill, Niolette I, Cooke, Howard, Masumoto, Hiroshi

“…To construct a mammalian artificial chromosome (MAC), telomere repeats and selectable markers were introduced into a 100 kb yeast artificial chromosome (YAC)…”
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Interphase FISH demonstrates that human adipose stromal cells maintain a high level of genomic stability in long-term culture by Grimes, Brenda R, Steiner, Camie M, Merfeld-Clauss, Stephanie, Traktuev, Dmitry O, Smith, Danielle, Reese, Angela, Breman, Amy M, Thurston, Virginia C, Vance, Gail H, Johnstone, Brian H, Slee, Roger B, March, Keith L

“…Human adipose stromal cells (ASCs) reside within the stromal-vascular fraction (SVF) in fat tissue, can be readily isolated, and include stem-like cells that…”
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Input DNA Ratio Determines Copy Number of The 33 kb Factor IX Gene on De Novo Human Artificial Chromosomes by Breman, Amy M, Steiner, Camie M, Slee, Roger B, Grimes, Brenda R

“…Human artificial chromosomes (ACs) are non-integrating vectors that may be useful for gene therapy. They assemble in cultured cells following transfection of…”
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Identifying and genotyping transgene integration loci by Liang, Zhong, Breman, Amy Marie, Grimes, Brenda R, Rosen, Elliot D

“…The random germline integration of genetically engineered transgenes has been a powerful technique to study the role of particular genes in variety of…”
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Artificial and engineered chromosomes: developments and prospects for gene therapy by Grimes, Brenda R, Monaco, Zoia Larin

“…At the gene therapy session of the ICCXV Chromosome Conference (2004), recent advances in the construction of engineered chromosomes and de novo human…”
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α-Satellite DNA and Vector Composition Influence Rates of Human Artificial Chromosome Formation by Grimes, Brenda R., Rhoades, Angela A., Willard, Huntington F.

“…Human artificial chromosomes (HACs) have been proposed as a new class of potential gene transfer and gene therapy vector. HACs can be formed when bacterial…”
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Stable gene expression from a mammalian artificial chromosome by Grimes, Brenda R, Schindelhauer, Dirk, McGill, Nio I, Ross, Andrew, Ebersole, Thomas A, Cooke, Howard J

“…We have investigated the potential of PAC‐based vectors as a route to the incorporation of a gene in a mammalian artificial chromosome (MAC). Previously we…”
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Assembly and characterization of heterochromatin and euchromatin on human artificial chromosomes by Grimes, Brenda R, Babcock, Jennifer, Rudd, M Katharine, Chadwick, Brian, Willard, Huntington F

“…Human centromere regions are characterized by the presence of alpha-satellite DNA, replication late in S phase and a heterochromatic appearance. Recent models…”
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Assay of centromere function using a human artificial chromosome by Masumoto, H, Ikeno, M, Nakano, M, Okazaki, T, Grimes, B, Cooke, H, Suzuki, N

“…In order to define a functional human centromere sequence, an artificial chromosome was constructed as a reproducible DNA molecule. Mammalian telomere repeats…”
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Recurrence risk in early breast cancer as defined by clinicopathologic features by Sheffield, Kristin M., Peachey, Jessica R., Method, Michael W., Grimes, Brenda R., Brown, Jacqueline, Saverno, Kim R., Zhu, Yajun Emily, Lee, Kimberley T

“…Abstract only e18581 Background: While most patients (pts) with HR+, HER2- early breast cancer (EBC) do not experience disease recurrence, those with high risk…”
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Phenotypic plasticity in normal breast derived epithelial cells by Sauder, Candice A M, Koziel, Jillian E, Choi, MiRan, Fox, Melanie J, Grimes, Brenda R, Badve, Sunil, Blosser, Rachel J, Radovich, Milan, Lam, Christina C, Vaughan, Melville B, Herbert, Brittney-Shea, Clare, Susan E

“…Normal, healthy human breast tissue from a variety of volunteer donors has become available for research thanks to the establishment of the Susan G. Komen for…”
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