The efficacy of a blended intervention to improve physical activity and protein intake for optimal physical recovery after oncological gastrointestinal and lung cancer surgery, the Optimal Physical Recovery After Hospitalization (OPRAH) trial: study protocol for a randomized controlled multicenter trial

The efficacy of a blended intervention to improve physical activity and protein intake for optimal physical recovery after oncological gastrointestinal and lung cancer surgery, the Optimal Physical Recovery After Hospitalization (OPRAH) trial: study protocol for a randomized controlled multicenter trial

Background Improving physical activity, especially in combination with optimizing protein intake, after surgery has a potential positive effect on recovery of physical functioning in patients after gastrointestinal and lung cancer surgery. The aim of this randomized controlled trial is to evaluate t...

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Published in:Current controlled trials in cardiovascular medicine Vol. 24; no. 1; p. 757
Main Authors: de Leeuwerk, Marijke, de Groot, Vincent, Dam, Suzanne ten, Kruizenga, Hinke, Weijs, Peter, Geleijn, Edwin, van der Leeden, Marike, van der Schaaf, Marike, Dickhoff, Chris, Besselink, Marc G, Tuynman, Jurriaan B, van Berge Henegouwen, Mark I, Erdmann, Joris I, Huijsmans, Rosalie J, van der Ploeg, Hidde P, Eskes, Anne M, Pijnappels, Mirjam A. G. M, van Leeuwen, Liesbeth Schuijs, Smits, Anke B, van Dijk, Jasmijn, Grimbergen, Eva
Format: Journal Article
Language:English
Published: BioMed Central Ltd 27-11-2023
BioMed Central
BMC
Subjects:
Accelerometers
Cancer
Cancer surgery
Care and treatment
Coaching
Diagnosis
Esophagus
Exercise
Gastrectomy
Gastric cancer
Health aspects
Hospitalization
Hypotheses
Informed consent
Intervention
Lung cancer
Patient outcomes
Patients
Physical activity
Physical functioning
Physiological aspects
Protein intake
Proteins
Quality of life
Questionnaires
Recovery (Medical)
Recovery of function
Rehabilitation
Schedules
Smartphones
Supportive care
Surgery
Netherlands
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Summary:Background Improving physical activity, especially in combination with optimizing protein intake, after surgery has a potential positive effect on recovery of physical functioning in patients after gastrointestinal and lung cancer surgery. The aim of this randomized controlled trial is to evaluate the efficacy of a blended intervention to improve physical activity and protein intake after hospital discharge on recovery of physical functioning in these patients. Methods In this multicenter single-blinded randomized controlled trial, 161 adult patients scheduled for elective gastrointestinal or lung cancer surgery will be randomly assigned to the intervention or control group. The purpose of the Optimal Physical Recovery After Hospitalization (OPRAH) intervention is to encourage self-management of patients in their functional recovery, by using a smartphone application and corresponding accelerometer in combination with coaching by a physiotherapist and dietician during three months after hospital discharge. Study outcomes will be measured prior to surgery (baseline) and one, four, eight, and twelve weeks and six months after hospital discharge. The primary outcome is recovery in physical functioning six months after surgery, and the most important secondary outcome is physical activity. Other outcomes include lean body mass, muscle mass, protein intake, symptoms, physical performance, self-reported limitations in activities and participation, self-efficacy, hospital readmissions and adverse events. Discussion The results of this study will demonstrate whether a blended intervention to support patients increasing their level of physical activity and protein intake after hospital discharge improves recovery in physical functioning in patients after gastrointestinal and lung cancer surgery. Trial registration The trial has been registered at the International Clinical Trials Registry Platform at 14-10-2021 with registration number NL9793. Trial registration data are presented in Table 1. Keywords: Cancer, Surgery, Supportive care, Physical functioning, Physical activity, Protein intake
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ISSN:1745-6215
1745-6215
DOI:10.1186/s13063-023-07705-2