Search Results - "Grimany‐Nuno, Orlando"

Pancreatic islets engineered with a FasL protein induce systemic tolerance at the induction phase that evolves into long‐term graft‐localized immune privilege by Woodward, Kyle B., Zhao, Hong, Shrestha, Pradeep, Batra, Lalit, Tan, Min, Grimany‐Nuno, Orlando, Bandura‐Morgan, Laura, Askenasy, Nadir, Shirwan, Haval, Yolcu, Esma S.

“…We have previously shown that pancreatic islets engineered to transiently display a modified form of FasL protein (SA‐FasL) on their surface survive…”
Get full text

Localized Immunomodulation with PD-L1 Results in Sustained Survival and Function of Allogeneic Islets without Chronic Immunosuppression by Batra, Lalit, Shrestha, Pradeep, Zhao, Hong, Woodward, Kyle B, Togay, Alper, Tan, Min, Grimany-Nuno, Orlando, Malik, Mohammad Tariq, Coronel, María M, García, Andrés J, Shirwan, Haval, Yolcu, Esma S

“…Allogeneic islet transplantation is limited by adverse effects of chronic immunosuppression used to control rejection. The programmed cell death 1 pathway as…”
Get full text

Fas Ligand-Modified Scaffolds Protect Stem Cell Derived β‑Cells by Modulating Immune Cell Numbers and Polarization by Li, Feiran, Crumley, Kelly, Bealer, Elizabeth, King, Jessica L., Saito, Eiji, Grimany-Nuno, Orlando, Yolcu, Esma S., Shirwan, Haval, Shea, Lonnie D.

“…Stem cell derived β-cells have demonstrated the potential to control blood glucose levels and represent a promising treatment for Type 1 diabetes (T1D). Early…”
Get full text

IMMUNOMODULATION WITH SA-PDL1 PROTEIN ON PANCREATIC ISLETS PROMOTES INDEFINITE GRAFT SURVIVAL IN ALLOGENEIC RECIPIENTS by Batra, Lalit, Shrestha, Pradeep, Zhao, Hong, Woodward, Kyle B., Togay, Alper, Tan, Min, Grimany-Nuno, Orlando, Malik, Mohammad Tariq, Coronel, María M., García, Andrés J., Shirwan, Haval, Yolcu, Esma

Get full text

Localized Immunomodulation with PD-L1 Results in Sustained Survival and Function of Allogeneic Islets without Chronic Immunosuppression1 by Batra, Lalit, Shrestha, Pradeep, Zhao, Hong, Woodward, Kyle B., Togay, Alper, Tan, Min, Grimany-Nuno, Orlando, Malik, Mohammad Tariq, Coronel, María M., García, Andrés J., Shirwan, Haval, Yolcu, Esma S.

“…Allogeneic islet transplantation is limited by adverse effects of chronic immunosuppression used to control rejection. The PD-1 pathway as an important immune…”
Get full text

FasL microgels induce immune acceptance of islet allografts in nonhuman primates by Lei, Ji, Coronel, María M, Yolcu, Esma S, Deng, Hongping, Grimany-Nuno, Orlando, Hunckler, Michael D, Ulker, Vahap, Yang, Zhihong, Lee, Kang M, Zhang, Alexander, Luo, Hao, Peters, Cole W, Zou, Zhongliang, Chen, Tao, Wang, Zhenjuan, McCoy, Colleen S, Rosales, Ivy A, Markmann, James F, Shirwan, Haval, García, Andrés J

“…Islet transplantation to treat insulin-dependent diabetes is greatly limited by the need for maintenance immunosuppression. We report a strategy through which…”
Get full text

The direct display of costimulatory proteins on tumor cells as a means of vaccination for cancer immunotherapy by Shirwan, Haval, Yolcu, Esma S, Sharma, Rajesh K, Zaho, Hong, Grimany-Nuno, Orlando

“…Therapeutic vaccines against cancer are at their prime, owing to our comprehensive understanding of immune effector responses generated against tumor and the…”
Get more information