Search Results - "Grimaldo, Enrique"

Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas by Amani, Vladimir, Riemondy, Kent A, Fu, Rui, Griesinger, Andrea M, Grimaldo, Enrique, De Sousa, Graziella Ribeiro, Gilani, Ahmed, Hemenway, Molly, Foreman, Nicholas K, Donson, Andrew M, Willard, Nicholas

“…Plexiform neurofibroma (PN) is a leading cause of morbidity in children with the genetic condition Neurofibromatosis Type 1 (NF1), often disfiguring or…”
Get full text

ATRT-19. CELL SURFACE PROTEOME ANALYSIS OF ATRT IDENTIFIES CD44V6 AS A CAR TARGET by Cole, Allison, Hoffmeyer, Eric, Grimaldo, Enrique, Donson, Andrew, Vibhakar, Rajeev, Nellan, Anandani, Mitra, Siddhartha S

“…Atypical teratoid rhabdoid tumor (ATRT) is an uncommon, aggressive tumor affecting the brain and spinal cord primarily in children. Despite significant strides…”
Get full text

EPEN-08. COMBINED PDGFR INHIBITOR AXITINIB AND RETINOID TRETINOIN DECREASES PROLIFERATION AND HIGH-RISK NEOPLASTIC SUBPOPULATION PROPORTIONS PFA EPENDYMOMA by Donson, Andrew, Grimaldo, Enrique, Riemondy, Kent, Griesinger, Andrea, Amani, Vladimir, Brunt, Breauna, Pierce, Angela, Foreman, Nicholas

“…Ependymoma (EPN) is fatal in over 50% of children and has not seen any therapeutic improvements in over 30 years. Based on data from single-cell RNA sequencing…”
Get full text

ETMR-22. IDENTIFICATION OF 5-FLUROURACIL AS A SELECTIVE THERAPY IN A NOVEL EP300::BCOR FUSION GLIOMA TUMOR MODEL by Donson, Andrew M, Amani, Vladimir, Griesinger, Andrea M, Calzadilla, Annaliese, Grimaldo, Enrique, Willard, Nicholas, Foreman, Nicholas K, Mulcahy-Levy, Jean

Get full text

EPEN-12. Sunitinib induces apoptosis-mediated cytotoxicity in PFA ependymoma by O'Shaughnessy, Bohdan, Donson, Andrew, Amani, Vladimir, Griesinger, Andrea, Grimaldo, Enrique, Harris, Faith, Foreman, Nicholas

“…Ependymoma (EPN) has been previously shown to be selectively targeted by three classes of FDA-approved chemotherapy drugs: fluorinated pyrimidines, retinoids,…”
Get full text

EPEN-23. TARGETING TRISOMY MDM4 INDUCES CELL DEATH IN 1Q+ PFA EPENDYMOMA THROUGH REACTIVATION OF THE P53 PATHWAY by Calzadilla, Annaliese J, Griesinger, Andrea M, Donson, Andrew M, Grimaldo, Enrique, Madhavan, Krishna, Alimova, Irina, Pierce, Angela M, Brunt, Breauna, Vibhakar, Rajeev, Foreman, Nicholas K

Get full text

EPEN-30. 5FU with Radiation Followed by Maintenance of 5FU and ATRA Significantly Improves Survival of 1q+/6q- PFA Ependymoma Xenograft Models by Grimaldo, Enrique, Donson, Andrew, Harris, Faith, Amani, Vladimir, Norris, Gregory, Steiner, Jenna, Serkova, Natalie, Dorris, Kathleen, Foreman, Nicholas, Griesinger, Andrea

“…In a screen of over 100 FDA approved drugs on PFA 1q+ EPN cells, 5-fluorouracil (5FU) and All-Trans-Retinoic Acid (ATRA) were identified as inhibitors of EPN…”
Get full text

MODL-26. Development of humanized immune system, posterior fossa A ependymoma patient-derived xenograft model by Griesinger, Andrea, Lang, Julie, Donson, Andrew, Grimaldo, Enrique, Pierce, Angela, Knox, Aaron, Steiner, Jenna, Serkova, Natalie, Ritzmann, Timothy, Grundy, Richard, Foreman, Nicholas

“…Cellular interactions between tumor and immune cells are critical in ependymoma biology. We have shown distinct immunobiology phenotypes by ependymoma…”
Get full text

EPEN-29. Spatial transcriptomic analysis of ependymoma implicates unresolved wound healing as a driver of tumor progression by Donson, Andrew, Fu, Rui, Norris, gregory, Willard, Nicholas, Griesinger, Andrea, Riemondy, Kent, Amani, Vladimir, Grimaldo, Enrique, Harris, Faith, Hankinson, Todd, Mitra, Siddhartha, Ritzmann, timothy, Grundy, Richard, Foreman, Nicholas

“…Ependymoma is a childhood brain tumor that remains incurable in approximately 50 percent of cases, most commonly in posterior fossa subgroup A (PFA)…”
Get full text

NFB-18. Integration of single-nuclei RNA-sequencing and spatial transcriptomics to define the complex tumor microenvironment of NF1-associated plexiform neurofibroma and highly-aggressive malignant peripheral nerve sheath tumors by Amani, Vladimir, Donson, Andrew, Riemondy, Kent, Fu, Rui, Willard, Nicholas, Gilani, Ahmed, Norris, Gregory, Griesinger, Andrea, Harris, Faith, Grimaldo, Enrique, Foreman, Nicholas

“…During formation of plexiform neurofibroma (PN), a complex tumor microenvironment (TME) develops, with recruitment of other cell types being critical for…”
Get full text

Spatial transcriptomic analysis delineates epithelial and mesenchymal subpopulations and transition stages in childhood ependymoma by Fu, Rui, Norris, Gregory A, Willard, Nicholas, Griesinger, Andrea M, Riemondy, Kent A, Amani, Vladimir, Grimaldo, Enrique, Harris, Faith, Hankinson, Todd C, Mitra, Siddhartha, Ritzmann, Timothy A, Grundy, Richard R, Foreman, Nicholas K, Donson, Andrew M

“…Abstract Background The diverse cellular constituents of childhood brain tumor ependymoma, recently revealed by single cell RNA-sequencing, may underly…”
Get full text

EPEN-07. A MULTICENTER STUDY OF POOR PROGNOSIS CHROMOSOME 1Q GAIN AND/OR 6Q LOSS IN POSTERIOR FOSSA A EPENDYMOMA SHOWS INCREASED PREVALENCE FROM 20% AT DIAGNOSIS TO 60% AT FIRST RECURRENCE by Donson, Andrew, Bertrand, Kelsey, Riemondy, Kent, Gao, Dexiang, Sanford, Bridget, Norris, Gregory, Fu, Rui, Willard, Nicholas, Griesinger, Andrea, Amani, Vladimir, Grimaldo, Enrique, Hankinson, Todd, Booker, Ffyona, Grundy, Richard, Pajtler, Kristian, Ellison, David, Ritzmann, Timothy

“…Ependymoma (EPN) posterior fossa group A (PFA) has the highest rate of recurrence and the worst prognosis of all EPN types. At relapse, it is typically…”
Get full text

Development of Chromosome 1q+ Specific Treatment for Highest Risk Pediatric Posterior Fossa Ependymoma by Griesinger, Andrea M, Calzadilla, Annaliese J, Grimaldo, Enrique, Donson, Andrew M, Amani, Vladimir, Pierce, Angela M, Steiner, Jenna, Kargar, Soudabeh, Serkova, Natalie J, Bertrand, Kelsey C, Wright, Karen D, Vibhakar, Rajeev, Hankinson, Todd, Handler, Michael, Lindsay, Holly B, Foreman, Nicholas K, Dorris, Kathleen

“…There are no effective treatment strategies for children with highest-risk posterior fossa group A ependymoma (PFA). Chromosome 1q gains (1q+) are present in…”
Get full text

EPEN-24. 5FU SENSITIVITY IS MEDIATED THROUGH TRISOMY UCK2 EXPRESSION IN 1Q+ PFA EPN by Griesingr, Andrea Marie, Calzadilla, Annaliese J, Grimaldo, Enrique, Donson, Andrew M, Amani, Vladimir, Pierce, Angela M, Steiner, Jena, Kargar, Soudabeh, Serkova, Natalie J, Bertrand, Kelsey C, Wright, Karen D, Vibhakar, Rajeev, Hankinson, Todd, Handler, Michael, Lindsay, Holly B, Foreman, Nicholas K, Dorris, Kathleen

Get full text

EPEN-07. SINGLE-CELL RNA SEQUENCING IDENTIFIES A UNIQUE MYELOID SUBPOPULATION ASSOCIATED WITH MESENCHYMAL TUMOR SUBPOPULATION IN POOR OUTCOME PEDIATRIC EPENDYMOMA by Griesinger, Andrea, Riemondy, Kent, Donson, Andrew, Willard, Nicholas, Prince, Eric, Harris, Faith, Amani, Vladimir, Grimaldo, Enrique, Hankinson, Todd, Grundy, Richard, Jackson, Andrew, Foreman, Nicholas, Ritzmann, Timothy

“…We have previously shown immune gene phenotype variations between posterior fossa ependymoma subgroups. PFA1 tumors chronically secrete IL-6, which induces…”
Get full text

EPEN-11. TUMOR DIFFERENTIATION IMPACTS THE BIOLOGY OF RECURRENCE IN CHILDHOOD POSTERIOR FOSSA EPENDYMOMA by Donson, Andrew, Ritzmann, Timothy, Willard, Nicholas, Griesinger, Andrea, Amani, Vladimir, Harris, Faith, Grimaldo, Enrique, Sanford, Bridget, Riemondy, Kent, Hankinson, Todd, Grundy, Richard, Foreman, Nicholas

“…Ependymoma (EPN) of childhood is curable in only 50% of cases, with recurrences in the remainder that are refractory to treatment. In recent years significant…”
Get full text

EPEN-26. Chemokine receptor blockade reverses CCL2 mediated immunosuppression and restores CAR-T cell function in posterior fossa ependymoma by Cole, Allison P, Donson, Andrew M, Pierce, Angela M, Grimaldo, Enrique, Calhoun, Jacob D, Griesinger, Andrea M, Sublett, Caroline, Kaplan, Rosandra N, Fry, Terry J, Foreman, Nicholas K, Nellan, Anandani

“…Trastuzumab-based HER2 CAR-T constructs have demonstrated preclinical efficacy in medulloblastoma and are being evaluated for use in children and young adults…”
Get full text

Significant increase of high-risk chromosome 1q gain and 6q loss at recurrence in posterior fossa group A ependymoma: A multicenter study by Donson, Andrew M, Bertrand, Kelsey C, Riemondy, Kent A, Gao, Dexiang, Zhuang, Yonghua, Sanford, Bridget, Norris, Gregory A, Chapman, Rebecca J, Fu, Rui, Willard, Nicholas, Griesinger, Andrea M, Ribeiro de Sousa, Graziella, Amani, Vladimir, Grimaldo, Enrique, Hankinson, Todd C, Booker, Ffyona, Sill, Martin, Grundy, Richard G, Pajtler, Kristian W, Ellison, David W, Foreman, Nicholas K, Ritzmann, Timothy A

“…Abstract Background Ependymoma (EPN) posterior fossa group A (PFA) has the highest rate of recurrence and the worst prognosis of all EPN molecular groups. At…”
Get full text

EPEN-21. EXPLORATION OF TUMOR SUPPRESSOR LATS1 LOSS IN POSTERIOR FOSSA GROUP A EPENDYMOMA WITH LOSS OF CHROMOSOME 6Q by Donson, Andrew M, Griesinger, Andrea M, Calzadilla, Annaliese, Amani, Vladimir, Grimaldo, Enrique, Foreman, Nicholas K

Get full text

Managing size selectivity: the relevance of compulsory and alternative selection devices in the Northeast Atlantic bottom trawl fishery by Brinkhof, Jesse, Sistiaga, Manu, Herrmann, Bent, Grimaldo, Eduardo, Larsen, Roger B

“…Two decades of use of the compulsory selectivity gear configuration in the Northeast Atlantic bottom trawl fishery, which consists of a rigid sorting grid…”
Get full text