Search Results - "Grimaldi, C. M."

Artificial increase of uracilemia during fluoropyrimidine treatment can lead to DPD deficiency misinterpretation by Thomas, F., Maillard, M., Launay, M., Tron, C., Etienne-Grimaldi, M.-C., Gautier-Veyret, E., Haufroid, V., Pallet, N., Royer, B., Narjoz, C., Schmitt, A.

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Clinical value of circulating endothelial cells and circulating tumor cells in metastatic breast cancer patients treated first line with bevacizumab and chemotherapy by Bidard, F.-C., Mathiot, C., Degeorges, A., Etienne-Grimaldi, M.-C., Delva, R., Pivot, X., Veyret, C., Bergougnoux, L., de Cremoux, P., Milano, G., Pierga, J.-Y.

“…We investigated whether circulating tumor cells (CTCs) and circulating endothelial cells (CECs) predict clinical outcome of first-line chemotherapy combined…”
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Resilience to periodic disturbances and the long-term genetic stability in Acropora coral by Thomas, L., Şahin, D., Adam, A. S., Grimaldi, C. M., Ryan, N. M., Duffy, S. L., Underwood, J. N., Kennington, W. J., Gilmour, J. P.

“…Climate change is restructuring natural ecosystems. The direct impacts of these events on biodiversity and community structure are widely documented, but the…”
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Combination of sunitinib, cetuximab and irradiation in an orthotopic head and neck cancer model by Bozec, A., Sudaka, A., Toussan, N., Fischel, J.-L., Etienne-Grimaldi, M.-C., Milano, G.

“…Recent preclinical and clinical studies indicate beneficial effects from combining radiotherapy with either anti-angiogenic drugs or anti-epidermal growth…”
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Analysis of the dinucleotide repeat polymorphism in the epidermal growth factor receptor (EGFR) gene in head and neck cancer patients by Etienne-Grimaldi, M.-C., Pereira, S., Magné, N., Formento, J.-L., Francoual, M., Fontana, X., Demard, F., Dassonville, O., Poissonnet, G., Santini, J., Bensadoun, R.-J., Szepetowski, P., Milano, G.

“…Background:: Epidermal growth factor receptor (EGFR) overexpression is associated with poor prognosis in head and neck cancer. The first intron of EGFR gene is…”
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Molecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study by Etienne-Grimaldi, M-C, Mahamat, A, Chazal, M, Laurent-Puig, P, Olschwang, S, Gaub, M-P, Formento, J-L, Formento, P, Sudaka, A, Boige, V, Abderrahim-Ferkoune, A, Benchimol, D, André, T, Houry, S, Faucheron, J-L, Letoublon, C, Gilly, F-N, Delpero, J-R, Lasser, P, Pradere, B, Pezet, D, Penault-Llorca, F, Milano, G

“…Background: To test the prognostic value of tumour protein and genetic markers in colorectal cancer (CRC) and examine whether deficient mismatch repair (dMMR)…”
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Pharmacological background of EGFR targeting by Castillo, L., Etienne-Grimaldi, M. C., Fischel, J. L., Formento, P., Magné, N., Milano, G.

“…Epidermal growth factor receptor (EGFR) signaling pathways play a key role in the regulation of cell proliferation, survival and differentiation. As a…”
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Epidermal growth factor receptor (EGFR) status and K-Ras mutations in colorectal cancer by Milano, G., Etienne-Grimaldi, M.-C., Dahan, L., Francoual, M., Spano, J.-P., Benchimol, D., Chazal, M., Letoublon, C., André, T., Gilly, F.-N., Delpero, J.-R., Formento, J.-L.

“…Background: In advanced colorectal cancer, K-Ras somatic mutations predict resistance to mAbs targeting epidermal growth factor receptor (EGFR). Relationships…”
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EGFR in colorectal cancer: more than a simple receptor by Francoual, M., Etienne-Grimaldi, M.-C., Formento, J.-L., Benchimol, D., Bourgeon, A., Chazal, M., Letoublon, C., André, T., Gilly, N., Delpero, J.-R., Lasser, P., Spano, J.-P., Milano, G.

“…Advances in the understanding of tumor biology have led to the development of targeted therapies allowing progress in colorectal cancer treatment. One of the…”
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Cutting Edge: Expansion and Activation of A Population of Autoreactive Marginal Zone B Cells in a Model of Estrogen-Induced Lupus by Grimaldi, Christine M, Michael, Daniel J, Diamond, Betty

“…We have demonstrated previously that 17 beta-estradiol (E2) treatment of BALB/c mice transgenic for the heavy chain of a pathogenic anti-DNA Ab induces a…”
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Frequent intragenic rearrangements of DPYD in colorectal tumours by van Kuilenburg, A B P, Etienne-Grimaldi, M-C, Mahamat, A, Meijer, J, Laurent-Puig, P, Olschwang, S, Gaub, M-P, Hennekam, R C M, Benchimol, D, Houry, S, Letoublon, C, Gilly, F-N, Pezet, D, Andre, T, Faucheron, J-L, Abderrahim-Ferkoune, A, Vijzelaar, R, Pradere, B, Milano, G

“…Dihydropyrimidine dehydrogenase is a crucial enzyme for the degradation of 5-fluorouracil (5FU). DPYD, which encodes dihydropyrimidine dehydrogenase, is prone…”
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Supra-additive antitumor effect of sunitinib malate (SU11248, Sutent®) combined with docetaxel. A new therapeutic perspective in hormone refractory prostate cancer by Guérin, O., Formento, P., Lo Nigro, C., Hofman, P., Fischel, J. L., Etienne-Grimaldi, M. C., Merlano, M., Ferrero, J. M., Milano, G.

“…Purpose Physiological and molecular findings indicate over-expression of HER proteins and dysregulation of neo-angiogenesis during progression of advanced…”
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Aluminium chloride‐induced toxicity in zebrafish larvae by Monaco, A, Grimaldi, M C, Ferrandino, I

“…Embryos at shield stage and larvae at protruding mouth stage were exposed to different concentrations of aluminium chloride (AlCl3) for 72 h with the purpose…”
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Chronopharmacokinetics of Oral Tegafur and Uracil in Colorectal Cancer Patients by Etienne‐Grimaldi, M‐C, Cardot, J‐M, François, E, Renée, N, Douillard, J‐Y, Gamelin, E, Milano, G

“…Uracil‐Ftorafur (UFT) combines the 5‐fluorouracil (FU) prodrug tegafur with uracil (at a 1:4 molar ratio), which is a competitive inhibitor of…”
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PK PD Model of Indisulam and Capecitabine: Interaction Causes Excessive Myelosuppression by Zandvliet, AS, Siegel‐Lakhai, WS, Beijnen, JH, Copalu, W, Etienne‐Grimaldi, M‐C, Milano, G, Schellens, JHM, Huitema, ADR

“…The anticancer agent indisulam was evaluated in a dose‐escalation study in combination with capecitabine. Severe myelotoxicity was observed after multiple…”
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Hydrodynamic and atmospheric drivers create distinct thermal environments within a coral reef atoll by Grimaldi, C. M., Lowe, R. J., Benthuysen, J. A., Cuttler, M. V. W., Green, R. H., Gilmour, J. P.

“…Within coral reefs, different thermal environments can be found at locations separated by less than 100 s of meters and can generate fine-scale patterns of…”
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EGFR expression in colon cancer: a break in the clouds by Etienne-Grimaldi, M-C, Cayre, A, Penault-Llorca, F, Francoual, M, Formento, J-L, Benchimol, D, Bourgeon, A, Milano, G

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Gefitinib–trastuzumab combination on hormone-refractory prostate cancer xenograft by Formento, Patricia, Hannoun-Levi, Jean-Michel, Gérard, Françoise, Mazeau, Christiane, Fischel, Jean-Louis, Etienne-Grimaldi, M.C., Gugenheim, Jean, Milano, Gérard

“…New drugs and new combinations of drugs have recently shown promising clinical activity in hormone refractory prostate cancer. We studied the association of…”
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Microsatellite allelic homoplasy due to variable flanking sequences by Grimaldi, M C, Crouau-Roy, B

“…Microsatellite DNA sequences have become the dominant source of nuclear genetic markers for most applications. It is important to investigate the basis of…”
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The applications of Wearable Cardioverter Defibrillators in Heart Failure and beyond by Rocco, E, Angelini, A, Simeone, B, Grimaldi, M C, Pinnacchio, G, Narducci, M L, Pelargonio, G

“…Wearable cardioverter defibrillator has revealed a crucial device both in patients with a clear indication of ICD implantation but with temporary…”
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