Search Results - "Grim, Joseph C."

Extended Exposure to Stiff Microenvironments Leads to Persistent Chromatin Remodeling in Human Mesenchymal Stem Cells by Killaars, Anouk R., Grim, Joseph C., Walker, Cierra J., Hushka, Ella A., Brown, Tobin E., Anseth, Kristi S.

“…Bone marrow derived human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies; however, ex vivo expansion is often required…”
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Antigen structure affects cellular routing through DC-SIGN by Jarvis, Cassie M., Zwick, Daniel B., Grim, Joseph C., Alam, Mohammad Murshid, Prost, Lynne R., Gardinerd, Jaye C., Park, Soyeong, Zimdars, Laraine L., Sherer, Nathan M., Kiessling, Laura L.

“…Dendritic cell (DC) lectins mediate the recognition, uptake, and processing of antigens, but they can also be coopted by pathogens for infection. These…”
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A Reversible and Repeatable Thiol–Ene Bioconjugation for Dynamic Patterning of Signaling Proteins in Hydrogels by Grim, Joseph C, Brown, Tobin E, Aguado, Brian A, Chapnick, Douglas A, Viert, Alexandrea L, Liu, Xuedong, Anseth, Kristi S

“…Biomolecule-functionalized hydrogels have emerged as valuable cell culture platforms to recapitulate the mechanical and biochemical properties of the…”
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Noncarbohydrate Glycomimetics and Glycoprotein Surrogates as DC-SIGN Antagonists and Agonists by Prost, Lynne R, Grim, Joseph C, Tonelli, Marco, Kiessling, Laura L

“…An understanding of the biological roles of lectins will be advanced by ligands that can inhibit or even recruit lectin function. To this end, glycomimetics,…”
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Mesenchymal stem cell‐inspired microgel scaffolds to control macrophage polarization by Caldwell, Alexander S., Rao, Varsha V., Golden, Alyxandra C., Bell, Daniel J., Grim, Joseph C., Anseth, Kristi S.

“…There is a desire in regenerative medicine to create biofunctional materials that can control and direct cell function in a precise manner. One particular stem…”
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Glycopolymer probes of signal transduction by Kiessling, Laura L, Grim, Joseph C

“…Glycans are key participants in biological processes ranging from reproduction to cellular communication to infection. Revealing glycan roles and the…”
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Osteopontin activity modulates sex‐specific calcification in engineered valve tissue mimics by Schroeder, Megan E., Batan, Dilara, Gonzalez Rodriguez, Andrea, Speckl, Kelly F., Peters, Douglas K., Kirkpatrick, Bruce E., Hach, Grace K., Walker, Cierra J., Grim, Joseph C., Aguado, Brian A., Weiss, Robert M., Anseth, Kristi S.

“…Patients with aortic valve stenosis (AVS) have sexually dimorphic phenotypes in their valve tissue, where male valvular tissue adopts a calcified phenotype and…”
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Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels by Grim, Joseph C., Marozas, Ian A., Anseth, Kristi S.

“…Hydrogels have emerged as promising scaffolds in regenerative medicine for the delivery of biomolecules to promote healing. However, increasing evidence…”
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Engineering precision biomaterials for personalized medicine by Aguado, Brian A, Grim, Joseph C, Rosales, Adrianne M, Watson-Capps, Jana J, Anseth, Kristi S

“…As the demand for precision medicine continues to rise, the "one-size-fits-all" approach to designing medical devices and therapies is becoming increasingly…”
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Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells by Grim, Joseph C., Aguado, Brian A., Vogt, Brandon J., Batan, Dilara, Andrichik, Cassidy L., Schroeder, Megan E., Gonzalez-Rodriguez, Andrea, Yavitt, F. Max, Weiss, Robert M., Anseth, Kristi S.

“…OBJECTIVE:Resident valvular interstitial cells (VICs) activate to myofibroblasts during aortic valve stenosis progression, which further promotes fibrosis or…”
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Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts by Aguado, Brian A., Walker, Cierra J., Grim, Joseph C., Schroeder, Megan E., Batan, Dilara, Vogt, Brandon J., Rodriguez, Andrea Gonzalez, Schwisow, Jessica A., Moulton, Karen S., Weiss, Robert M., Heistad, Donald D., Leinwand, Leslie A., Anseth, Kristi S.

“…Aortic valve stenosis is a sexually dimorphic disease, with women often presenting with sustained fibrosis and men with more extensive calcification. However,…”
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Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts by Walker, Cierra J., Crocini, Claudia, Ramirez, Daniel, Killaars, Anouk R., Grim, Joseph C., Aguado, Brian A., Clark, Kyle, Allen, Mary A., Dowell, Robin D., Leinwand, Leslie A., Anseth, Kristi S.

“…Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently activated fibroblasts (also known as myofibroblasts), even…”
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Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation by Aguado, Brian A, Schuetze, Katherine B, Grim, Joseph C, Walker, Cierra J, Cox, Anne C, Ceccato, Tova L, Tan, Aik-Choon, Sucharov, Carmen C, Leinwand, Leslie A, Taylor, Matthew R G, McKinsey, Timothy A, Anseth, Kristi S

“…The transcatheter aortic valve replacement (TAVR) procedure has emerged as a minimally invasive treatment for patients with aortic valve stenosis (AVS)…”
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Tumor necrosis factor‐α promotes and exacerbates calcification in heart valve myofibroblast populations by Gonzalez Rodriguez, Andrea, Schroeder, Megan E., Grim, Joseph C., Walker, Cierra J., Speckl, Kelly F., Weiss, Robert M., Anseth, Kristi S.

“…Pro‐inflammatory cytokines play critical roles in regulating valvular interstitial cell (VIC) phenotypic changes that can cause heart valve fibrosis and…”
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Collagen networks within 3D PEG hydrogels support valvular interstitial cell matrix mineralization by Schroeder, Megan E., Gonzalez Rodriguez, Andrea, Speckl, Kelly F., Walker, Cierra J., Midekssa, Firaol S., Grim, Joseph C., Weiss, Robert M., Anseth, Kristi S.

“…Enzymatically degradable hydrogels were designed for the 3D culture of valvular interstitial cells (VICs), and through the incorporation of various…”
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Glycomimetic Building Blocks: A Divergent Synthesis of Epimers of Shikimic Acid by Grim, Joseph C, Garber, Kathleen C. A, Kiessling, Laura L

“…A divergent synthesis of (−)-4-epi-shikimic acid was developed. This route features a one-pot zinc-mediated reductive ring opening of an arabinofuranose…”
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Author Correction: Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts by Walker, Cierra J., Crocini, Claudia, Ramirez, Daniel, Killaars, Anouk R., Grim, Joseph C., Aguado, Brian A., Clark, Kyle, Allen, Mary A., Dowell, Robin D., Leinwand, Leslie A., Anseth, Kristi S.

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Secreted factors from pro-inflammatory macrophages promote an osteoblast-like phenotype in valvular interstitial cells by Grim, Joseph C., Aguado, Brian A., Vogt, Brandon J., Batan, Dilara, Andrichik, Cassidy L., Schroeder, Megan E., Gonzalez-Rodriguez, Andrea, Yavitt, F. Max, Weiss, Robert M., Anseth, Kristi S.

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Engineered Hydrogels as Valve Tissue Mimetics That Recapitulate Sexual Dimorphisms Observed in Calcification and Osteopontin Activity by Schroeder, Megan E., Gonzalez Rodriquez, Andrea, Speckl, Kelly, Peters, Douglas K., Walker, Cierra J., Aguado, Brian A., Grim, Joseph C., Weiss, Robert M., Anseth, Kristi

“…Objective: Recent clinical reports indicate that patients with calcific aortic valve stenosis (AVS) have sexually dimorphic disease phenotypes, where female…”
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Synthetic Hydrogels Reveal the Role of the Matrix Microenvironment on Aortic Valve Calcification by Schroeder, Megan E., Gonzalez Rodriguez, Andrea, Speckl, Kelly F., Walker, Cierra J., Midekssa, Firaol S., Grim, Joseph C., Weiss, Robert M., Anseth, Kristi S.

“…Objective: Calcific aortic valve disease (CAVD) affects 2.5% of the US population over 75 and there remain no therapeutics, other than surgical replacement, to…”
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