Search Results - "Grilo, Luís F."

Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond by Grilo, Luís F., Tocantins, Carolina, Diniz, Mariana S., Gomes, Rodrigo Mello, Oliveira, Paulo J., Matafome, Paulo, Pereira, Susana P.

“…Embryonic and foetal development are critical periods of development in which several environmental cues determine health and disease in adulthood. Maternal…”
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P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by promoting pentose phosphate pathway and decreasing oxidative stress by Sousa, Bárbara, Pereira, Joana, Marques, Ricardo, Grilo, Luís F., Pereira, Susana P., Sardão, Vilma A., Schmitt, Fernando, Oliveira, Paulo J., Paredes, Joana

“…Successful metastatic spreading relies on cancer cells with stem-like properties, glycolytic metabolism and increased antioxidant protection, allowing them to…”
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Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy by Tocantins, Carolina, Martins, João D., Rodrigues, Óscar M., Grilo, Luís F., Diniz, Mariana S., Stevanovic-Silva, Jelena, Beleza, Jorge, Coxito, Pedro, Rizo-Roca, David, Santos-Alves, Estela, Moreno, António J., Ascensão, António, Magalhães, José, Oliveira, Paulo J., Pereira, Susana P.

“…Pregnancy may be a challenging period for the maternal systems and has been regarded as a stress test, as imperceptible/mild dysfunctions eventually present…”
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Development of a 96-well based assay for kinetic determination of catalase enzymatic-activity in biological samples by Grilo, Luís F., Martins, João D., Cavallaro, Chiara H., Nathanielsz, Peter W., Oliveira, Paulo J., Pereira, Susana P.

“…Oxidative stress biomarkers are powerful endpoints in toxicological research. Cellular reductive/oxidative balance affects numerous signaling pathways…”
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The birth of cardiac disease: Mechanisms linking gestational diabetes mellitus and early onset of cardiovascular disease in offspring by Tocantins, Carolina, Diniz, Mariana S., Grilo, Luís F., Pereira, Susana P.

“…Cardiovascular disease (CVD) is the biggest killer worldwide, composing a major economic burden for health care systems. Obesity and diabetes are dual…”
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Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb by Diniz, Mariana S, Grilo, Luís F, Tocantins, Carolina, Falcão-Pires, Inês, Pereira, Susana P

“…Obesity incidence has been increasing at an alarming rate, especially in women of reproductive age. It is estimated that 50% of pregnancies occur in overweight…”
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Metabolic mitochondrial alterations prevail in the female rat heart 8 weeks after exercise cessation by Tocantins, Carolina, Martins, João D, Rodrigues, Óscar M, Grilo, Luís F, Diniz, Mariana S, Stevanovic-Silva, Jelena, Beleza, Jorge, Coxito, Pedro, Rizo-Roca, David, Santos-Alves, Estela, Rios, Manoel, Carvalho, Lina, Moreno, António J, Ascensão, António, Magalhães, José, Oliveira, Paulo J, Pereira, Susana P

“…The consumption of high-caloric diets strongly contributes to the development of non-communicable diseases (NCDs), including cardiovascular disease, the…”
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The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development by Diniz, Mariana S., Tocantins, Carolina, Grilo, Luís F., Pereira, Susana P.

“…Type 2 diabetes (T2D) has increased worldwide at an alarming rate. Metabolic syndrome (MetS) is a major risk factor for T2D development. One of the main…”
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Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway by Grilo, Luís F., Zimmerman, Kip D., Puppala, Sobha, Chan, Jeannie, Huber, Hillary F., Li, Ge, Jadhav, Avinash Y. L., Wang, Benlian, Li, Cun, Clarke, Geoffrey D., Register, Thomas C., Oliveira, Paulo J., Nathanielsz, Peter W., Olivier, Michael, Pereira, Susana P., Cox, Laura A.

“…Age is a prominent risk factor for cardiometabolic disease, often leading to heart structural and functional changes. However, precise molecular mechanisms…”
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Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases by Diniz, Mariana S, Magalhães, Carina C, Tocantins, Carolina, Grilo, Luís F, Teixeira, José, Pereira, Susana P

“…Chronic diseases represent one of the major causes of death worldwide. It has been suggested that pregnancy-related conditions, such as gestational diabetes…”
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The Endocrine–Metabolic Axis Regulation in Offspring Exposed to Maternal Obesity—Cause or Consequence in Metabolic Disease Programming? by Grilo, Luís F., Diniz, Mariana S., Tocantins, Carolina, Areia, Ana L., Pereira, Susana P.

“…Obesity incidence is rising worldwide, including women of reproductive age, contributing to increased gestations in which Maternal Obesity (MO) occurs…”
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Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation by Di Sante, Moises, Antonucci, Salvatore, Pontarollo, Laura, Cappellaro, Ilaria, Segat, Francesca, Deshwal, Soni, Greotti, Elisa, Grilo, Luis F., Menabò, Roberta, Di Lisa, Fabio, Kaludercic, Nina

“…During embryonic development, cardiomyocytes undergo differentiation and maturation, processes that are tightly regulated by tissue-specific signaling…”
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Sex-Specific Impact of Maternal Obesity and Gestational Exercise on Offspring's Cardiac Health: Insights into Mitochondrial Function and NO Signaling by Pereira, Susana P., Diniz, Mariana S., Martins, João D., Rodrigues, Óscar M., Tocantins, Carolina, Grilo, Luís F., Carvalho, Lina, Stevanovic-Silva, Jelena, Beleza, Jorge, Coxito, Pedro, Rizo-Roca, David, Santos-Alves, Estela, Rios, Manoel, Moreno, António J., Ascensão, António, Magalhães, José, Oliveira, Paulo J.

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Age-Associated Glycosaminoglycans Accumulation In Heart Extracellular Matrix Via Hexosamine Biosynthetic Pathway Precedes Cardiac Hypertrophy by Grilo, Luís F., Zimmerman, Kip D., Puppala, Sobha, Chan, Jeannie, Ampong, Isaac, Huber, Hillary F., Li, Ge, Jadhav, Avinash Y.L., Wang, Benlian, Li, Cun, Clarke, Geoffrey D., Register, Thomas C., Oliveira, Paulo J., Nathanielsz, Peter W., Olivier, Michael, Pereira, Susana P., Cox, Laura A.

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Metabolic mitochondrial alterations prevail in the female rat heart 8weeks after exercise cessation by Tocantins, Carolina, Martins, João D, Rodrigues, Óscar M, Grilo, Luís F, Diniz, Mariana S, Jelena Stevanovic‐Silva, Beleza, Jorge, Coxito, Pedro, David Rizo‐Roca, Estela Santos‐Alves, Rios, Manoel, Carvalho, Lina, Moreno, António J, Ascensão, António, Magalhães, José, Oliveira, Paulo J, Pereira, Susana P

“…BackgroundThe consumption of high‐caloric diets strongly contributes to the development of non‐communicable diseases (NCDs), including cardiovascular disease,…”
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Biochimica et biophysica acta: Molecular basis of disease maternal heart exhibits metabolic and redox adapatations post-uncomplicated pregnancy by Tocantins, Carolina, Martins, João D, Rodrigues, Óscar M, Grilo, Luís F, Diniz, Mariana S, Stevanovic-Silva, Jelena, Beleza, Jorge, Coxito, Pedro, Rizo-Roca, David, Santos-Alves, Estela, Moreno, António J, Ascensão, António, Magalhães, José, Oliveira, Paulo J, Pereira, Susana P

“…Pregnancy may be a challenging period for the maternal systems and has been regarded as a stress test, as imperceptible/mild dysfunctions eventually present…”
Get full text