Search Results - "Grillasca, Ivonne"
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In vitro metabolism of gestodene in target organs: formation of A-ring reduced derivatives with oestrogenic activity
Published in European journal of pharmacology (13-04-2001)“…Gestodene (13β-ethyl-17α-ethynyl-17β-hydroxy-4,5-gonadien-3-one), the most potent progestin ever synthesized, stimulates breast cancer cell growth through an…”
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Assessment of the oestrogenic activity of the contraceptive progestin levonorgestrel and its non-phenolic metabolites
Published in European journal of pharmacology (14-09-2001)“…Levonorgestrel (13β-ethyl-17α-ethynyl-17β-hydroxy-4-gonen-3-one), a potent contraceptive progestin stimulates growth and proliferation of cultured breast…”
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5α-Reduction of norethisterone enhances its binding affinity for androgen receptors but diminishes its androgenic potency
Published in The Journal of steroid biochemistry and molecular biology (1997)“…Norethisterone (NET), a 19-nor synthetic progestin, undergoes enzyme-mediated 5α-reduction and exerts potent androgenic effects in target organs. To…”
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Mechanism of action of levonorgestrel: in vitro metabolism and specific interactions with steroid receptors in target organs
Published in The Journal of steroid biochemistry and molecular biology (01-03-1992)“…Levonorgestrel (LNG) is a synthetic steroid that displays potent progestational and androgenic effects but it lacks estrogen-like activity. To examine the mode…”
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Stereospecificity of the intracellular binding of norethisterone and its A-ring reduced metabolites
Published in Journal of steroid biochemistry (01-01-1985)“…The interaction of norethisterone (NET) and four A-ring reduced metabolites of NET with cytosol receptors for progesterone (PR), androgen (AR), and estrogen…”
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