Search Results - "Grill, W."

Phase separation of a yeast prion protein promotes cellular fitness by Franzmann, Titus M, Jahnel, Marcus, Pozniakovsky, Andrei, Mahamid, Julia, Holehouse, Alex S, Nüske, Elisabeth, Richter, Doris, Baumeister, Wolfgang, Grill, Stephan W, Pappu, Rohit V, Hyman, Anthony A, Alberti, Simon

“…Despite the important role of prion domains in neurodegenerative disease, their physiological function has remained enigmatic. Previous work with yeast prions…”
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Attachment of the blastoderm to the vitelline envelope affects gastrulation of insects by Münster, Stefan, Jain, Akanksha, Mietke, Alexander, Pavlopoulos, Anastasios, Grill, Stephan W., Tomancak, Pavel

“…During gastrulation, physical forces reshape the simple embryonic tissue to form the complex body plans of multicellular organisms 1 . These forces often cause…”
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Determining Physical Properties of the Cell Cortex by Saha, Arnab, Nishikawa, Masatoshi, Behrndt, Martin, Heisenberg, Carl-Philipp, Jülicher, Frank, Grill, Stephan W.

“…Actin and myosin assemble into a thin layer of a highly dynamic network underneath the membrane of eukaryotic cells. This network generates the forces that…”
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How Active Mechanics and Regulatory Biochemistry Combine to Form Patterns in Development by Gross, Peter, Kumar, K. Vijay, Grill, Stephan W

“…The development of organisms starting from their zygotic state involves a tight integration of the myriad biochemical signaling interactions with the…”
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Guiding self-organized pattern formation in cell polarity establishment by Gross, Peter, Kumar, K. Vijay, Goehring, Nathan W., Bois, Justin S., Hoege, Carsten, Jülicher, Frank, Grill, Stephan W.

“…Spontaneous pattern formation in Turing systems relies on feedback. But patterns in cells and tissues seldom form spontaneously—instead they are controlled by…”
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Tension and Force-Resistant Attachment Are Essential for Myofibrillogenesis in Drosophila Flight Muscle by Weitkunat, Manuela, Kaya-Çopur, Aynur, Grill, Stephan W., Schnorrer, Frank

“…Higher animals generate an elaborate muscle-tendon network to perform their movements. To build a functional network, developing muscles must establish stable…”
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Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows by Grill, Stephan W, Mayer, Mirjam, Depken, Martin, Bois, Justin S, Jülicher, Frank

“…Asymmetric cell divisions are essential for the development of multicellular organisms. To proceed, they require an initially symmetric cell to polarize. In…”
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Turing's next steps: the mechanochemical basis of morphogenesis by Howard, Jonathon, Grill, Stephan W, Bois, Justin S

“…Alan Turing showed that spatial patterns can be generated when two morphogens diffuse and react. Although he realized the importance of mechanics, it has only…”
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Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution by Chen, Bi-Chang, Legant, Wesley R., Wang, Kai, Shao, Lin, Milkie, Daniel E., Davidson, Michael W., Janetopoulos, Chris, Wu, Xufeng S., Hammer, John A., Liu, Zhe, English, Brian P., Mimori-Kiyosue, Yuko, Romero, Daniel P., Ritter, Alex T., Lippincott-Schwartz, Jennifer, Fritz-Laylin, Lillian, Mullins, R. Dyche, Mitchell, Diana M., Bembenek, Joshua N., Reymann, Anne-Cecile, Böhme, Ralph, Grill, Stephan W., Wang, Jennifer T., Seydoux, Geraldine, Tulu, U. Serdar, Kiehart, Daniel P., Betzig, Eric

“…Although fluorescence microscopy provides a crucial window into the physiology of living specimens, many biological processes are too fragile, are too small,…”
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Cortical flow aligns actin filaments to form a furrow by Reymann, Anne-Cecile, Staniscia, Fabio, Erzberger, Anna, Salbreux, Guillaume, Grill, Stephan W

“…Cytokinesis in eukaryotic cells is often accompanied by actomyosin cortical flow. Over 30 years ago, Borisy and White proposed that cortical flow converging…”
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Forces Driving Epithelial Spreading in Zebrafish Gastrulation by Behrndt, Martin, Salbreux, Guillaume, Campinho, Pedro, Hauschild, Robert, Oswald, Felix, Roensch, Julia, Grill, Stephan W., Heisenberg, Carl-Philipp

“…Contractile actomyosin rings drive various fundamental morphogenetic processes ranging from cytokinesis to wound healing. Actomyosin rings are generally…”
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Mechanisms of backtrack recovery by RNA polymerases I and II by Lisica, Ana, Engel, Christoph, Jahnel, Marcus, Roldán, Édgar, Galburt, Eric A., Cramer, Patrick, Grill, Stephan W.

“…During DNA transcription, RNA polymerases often adopt inactive backtracked states. Recovery from backtracks can occur by 1D diffusion or cleavage of…”
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HP1 proteins compact DNA into mechanically and positionally stable phase separated domains by Keenen, Madeline M, Brown, David, Brennan, Lucy D, Renger, Roman, Khoo, Harrison, Carlson, Christopher R, Huang, Bo, Grill, Stephan W, Narlikar, Geeta J, Redding, Sy

“…In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and…”
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Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation by Naumann, Marcel, Pal, Arun, Goswami, Anand, Lojewski, Xenia, Japtok, Julia, Vehlow, Anne, Naujock, Maximilian, Günther, René, Jin, Mengmeng, Stanslowsky, Nancy, Reinhardt, Peter, Sterneckert, Jared, Frickenhaus, Marie, Pan-Montojo, Francisco, Storkebaum, Erik, Poser, Ina, Freischmidt, Axel, Weishaupt, Jochen H., Holzmann, Karlheinz, Troost, Dirk, Ludolph, Albert C., Boeckers, Tobias M., Liebau, Stefan, Petri, Susanne, Cordes, Nils, Hyman, Anthony A., Wegner, Florian, Grill, Stephan W., Weis, Joachim, Storch, Alexander, Hermann, Andreas

“…Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic fused in sarcoma (FUS) aggregates are pathological hallmarks of…”
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Modeling the response of small myelinated axons in a compound nerve to kilohertz frequency signals by Pelot, N A, Behrend, C E, Grill, W M

“…There is growing interest in electrical neuromodulation of peripheral nerves, particularly autonomic nerves, to treat various diseases. Electrical signals in…”
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Forces Generated by Cell Intercalation Tow Epidermal Sheets in Mammalian Tissue Morphogenesis by Heller, Evan, Kumar, K. Vijay, Grill, Stephan W., Fuchs, Elaine

“…While gastrulation movements offer mechanistic paradigms for how collective cellular movements shape developing embryos, far less is known about coordinated…”
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Active torque generation by the actomyosin cell cortex drives left-right symmetry breaking by Naganathan, Sundar Ram, Fürthauer, Sebastian, Nishikawa, Masatoshi, Jülicher, Frank, Grill, Stephan W

“…Many developmental processes break left-right (LR) symmetry with a consistent handedness. LR asymmetry emerges early in development, and in many species the…”
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Controlling contractile instabilities in the actomyosin cortex by Nishikawa, Masatoshi, Naganathan, Sundar Ram, Jülicher, Frank, Grill, Stephan W

“…The actomyosin cell cortex is an active contractile material for driving cell- and tissue morphogenesis. The cortex has a tendency to form a pattern of myosin…”
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Polarization of PAR Proteins by Advective Triggering of a Pattern-Forming System by Goehring, Nathan W., Trong, Philipp Khuc, Bois, Justin S., Chowdhury, Debanjan, Nicola, Ernesto M., Hyman, Anthony A., Grill, Stephan W.

“…In the Caenorhobditis elegans zygote, a conserved network of partitioning-defective (PAR) polarity proteins segregates into an anterior and a posterior domain,…”
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Active chiral fluids by Fürthauer, S., Strempel, M., Grill, S. W., Jülicher, F.

“…Active processes in biological systems often exhibit chiral asymmetries. Examples are the chirality of cytoskeletal filaments which interact with motor…”
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