Search Results - "Grill, Joshua"

The approval of Aduhelm risks eroding public trust in Alzheimer research and the FDA by Karlawish, Jason, Grill, Joshua D.

“…The FDA has granted accelerated approval to aducanumab (Aduhelm) for the treatment of Alzheimer disease with an overly broad label. The decision disregarded…”
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Remaining Questions in a Brave New World of Alzheimer's Disease Care by Grill, Joshua D

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Disclosing Alzheimer Disease Biomarker Results to Research Participants by Grill, Joshua D, Karlawish, Jason

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Implications of FDA Approval of a First Disease-Modifying Therapy for a Neurodegenerative Disease on the Design of Subsequent Clinical Trials by Grill, Joshua D., Karlawish, Jason

“…The goal of clinical research is to improve clinical practice. In progressive neurodegenerative conditions without any disease-slowing therapies, this will…”
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Testing for Alzheimer Disease Biomarkers and Disclosing Results Across the Disease Continuum by Largent, Emily A., Grill, Joshua D., O'Brien, Kyra, Wolk, David, Harkins, Kristin, Karlawish, Jason

“…Three pathologic processes are characteristic of Alzheimer disease (AD)β-amyloid, hyperphosphorylated tau, and neurodegeneration. Our understanding of AD is…”
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Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials by Grill, Joshua D, Karlawish, Jason

“…Among the key challenges in Alzheimer's disease drug development is the timely completion of clinical trials. Unfortunately, clinical trials often suffer from…”
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What Should the Goals Be for Diverse Recruitment in Alzheimer Clinical Trials? by Grill, Joshua D, Sperling, Reisa A, Raman, Rema

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Centers for Medicare and Medicaid Services Coverage of Amyloid PET by Grill, Joshua D, Lingler, Jennifer H

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Disclosure of amyloid status is not a barrier to recruitment in preclinical Alzheimer’s disease clinical trials by Grill, Joshua, PhD, Zhou, Yan, PhD, Elashoff, David, PhD, Karlawish, Jason, MD

“…Abstract Preclinical Alzheimer’s disease (AD) clinical trials may require participants to learn if they meet biomarker enrollment criteria to enroll. To…”
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Alzheimer's disease biomarkers and the tyranny of treatment by Karlawish, Jason, Grill, Joshua D.

“…Advances in treatment are changing not only the therapeutic options for patients with Alzheimer's disease; they're also changing their diagnostic options…”
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Frameworks for estimating causal effects in observational settings: comparing confounder adjustment and instrumental variables by Zawadzki, Roy S, Grill, Joshua D, Gillen, Daniel L

“…To estimate causal effects, analysts performing observational studies in health settings utilize several strategies to mitigate bias due to confounding by…”
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Direct Mail Recruitment to a Potential Participant Registry by Gombosev, Adrijana, Salazar, Christian R., Hoang, Dan, Cox, Chelsea G., Gillen, Daniel L., Grill, Joshua D.

“…Recruitment registries are novel tools to accelerate Alzheimer disease research accrual. Optimal methods to populate such registries remain largely unstudied…”
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Facilitating Alzheimer Disease Research Recruitment by Grill, Joshua D., Galvin, James E.

“…Alzheimer disease (AD) research faces challenges to successful enrollment, especially to clinical trials and biomarker studies. Failure to recruit the planned…”
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Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment by Grill, Joshua D, Raman, Rema, Ernstrom, Karin, Sultzer, David L, Burns, Jeffrey M, Donohue, Michael C, Johnson, Keith A, Aisen, Paul S, Sperling, Reisa A, Karlawish, Jason

“…The goal of preclinical Alzheimer disease (AD) clinical trials is to move diagnosis and treatment to presymptomatic stages, which will require biomarker…”
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Post‐disclosure distress among racial and ethnic groups in a preclinical AD trial by Ritchie, Marina, Salazar, Christian R., Gillen, Daniel L., Grill, Joshua D.

“…INTRODUCTION Trialists need a thorough understanding of whether reactions to Alzheimer's disease (AD) biomarker information differ among racial and ethnic…”
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Retention of American Indian and Alaska Native participants in the National Alzheimer's Coordinating Center Uniform Data Set by Conniff, Kyle R, Grill, Joshua D, Gillen, Daniel L

“…The number of American Indian and Alaska Native (AI/AN) elders is expected to double by 2060. Thus it is imperative to retain AI/AN participants in…”
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Economic hardships of Korean American family caregivers of persons with dementia: a mixed-methods study by Lee, Kathy, Seo, Chang Hyun, Cassidy, Jessica, Shin, Hye-Won, Grill, Joshua D.

“…Objectives. This study examined the relationships between economic hardships (i.e. perceived financial hardship and job interference) and caregiver burden…”
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Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial by Raman, Rema, Quiroz, Yakeel T, Langford, Oliver, Choi, Jiyoon, Ritchie, Marina, Baumgartner, Morgan, Rentz, Dorene, Aggarwal, Neelum T, Aisen, Paul, Sperling, Reisa, Grill, Joshua D

“…Underrepresentation of many racial/ethnic groups in Alzheimer disease (AD) clinical trials limits generalizability of results and hinders opportunities to…”
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Eligibility Rates among Racially and Ethnically Diverse US Participants in Phase 2 and Phase 3 Placebo‐Controlled, Double‐Blind, Randomized Trials of Lecanemab and Elenbecestat in Early Alzheimer Disease by Grill, Joshua D., Flournoy, Charlene, Dhadda, Shobha, Ernstrom, Karin, Sperling, Reisa, Molina‐Henry, Doris, Tranotti, Kate, Harris, Russell, Kanekiyo, Michio, Gee, Michelle, Irizarry, Michael, Kramer, Lynn, Aisen, Paul, Raman, Rema

“…Objective Many factors contribute to inadequate diversity in Alzheimer disease (AD) clinical trials. We evaluated eligibility rates among racial and ethnic…”
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Examining Utilization of Formal Supports and Related Impacts on Overall Well-Being Among East Asian American Family Caregivers of Persons With Dementia: A Mixed-Methods Study by Lee, Kathy, Cassidy, Jessica, Lee, Jihui, Seo, Chang Hyun, Kunz Lomelin, Alan, Shin, Hye-Won, Grill, Joshua D

“…Abstract Background and Objectives Although East Asian American family caregivers are known to underutilize formal support services, there is a lack of…”
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