Search Results - "Grill, Jacques"

Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas by Bender, Sebastian, Tang, Yujie, Lindroth, Anders M., Hovestadt, Volker, Jones, David T.W., Kool, Marcel, Zapatka, Marc, Northcott, Paul A., Sturm, Dominik, Wang, Wei, Radlwimmer, Bernhard, Højfeldt, Jonas W., Truffaux, Nathalène, Castel, David, Schubert, Simone, Ryzhova, Marina, Şeker-Cin, Huriye, Gronych, Jan, Johann, Pascal David, Stark, Sebastian, Meyer, Jochen, Milde, Till, Schuhmann, Martin, Ebinger, Martin, Monoranu, Camelia-Maria, Ponnuswami, Anitha, Chen, Spenser, Jones, Chris, Witt, Olaf, Collins, V. Peter, von Deimling, Andreas, Jabado, Nada, Puget, Stephanie, Grill, Jacques, Helin, Kristian, Korshunov, Andrey, Lichter, Peter, Monje, Michelle, Plass, Christoph, Cho, Yoon-Jae, Pfister, Stefan M.

“…Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and…”
Get full text

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma by Grasso, Catherine S, Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E, Liu, Lining, Debily, Marie-Anne, Quist, Michael J, Davis, Lara E, Huang, Elaine C, Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B, Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Qi, Lin, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E, Le Dret, Ludivine, Meltzer, Paul S, Mao, Hua, Quezado, Martha, van Vuurden, Dannis G, Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N, Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M, Raabe, Eric H, Hulleman, Esther, Spellman, Paul T, Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle

“…The study describes the use of integrative approaches to search for candidate therapeutic targets for DIPG, and the identification of an HDAC inhibitor as a…”
Get full text

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma by Taylor, Kathryn R, Mackay, Alan, Truffaux, Nathalène, Butterfield, Yaron S, Morozova, Olena, Philippe, Cathy, Castel, David, Grasso, Catherine S, Vinci, Maria, Carvalho, Diana, Carcaboso, Angel M, de Torres, Carmen, Cruz, Ofelia, Mora, Jaume, Entz-Werle, Natacha, Ingram, Wendy J, Monje, Michelle, Hargrave, Darren, Bullock, Alex N, Puget, Stéphanie, Yip, Stephen, Jones, Chris, Grill, Jacques

“…Chris Jones, Jacques Grill and colleagues report the identification of recurrent activating mutations in ACVR1 in diffuse intrinsic pontine gliomas. Diffuse…”
Get full text

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR by Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David T W, Sahm, Felix

“…Abstract Background Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense…”
Get full text

Arterial Spin Labeling to Predict Brain Tumor Grading in Children: Correlations between Histopathologic Vascular Density and Perfusion MR Imaging by Dangouloff-Ros, Volodia, Deroulers, Christophe, Foissac, Frantz, Badoual, Mathilde, Shotar, Eimad, Grévent, David, Calmon, Raphael, Pagès, Mélanie, Grill, Jacques, Dufour, Christelle, Blauwblomme, Thomas, Puget, Stéphanie, Zerah, Michel, Sainte-Rose, Christian, Brunelle, Francis, Varlet, Pascale, Boddaert, Nathalie

“…Purpose To compare arterial spin labeling (ASL) data between low- and high-grade brain tumors in children to establish a cutoff to distinguish low- from…”
Get full text

Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial by Harttrampf, Anne C, Lacroix, Ludovic, Deloger, Marc, Deschamps, Frederic, Puget, Stephanie, Auger, Nathalie, Vielh, Philippe, Varlet, Pascale, Balogh, Zsofia, Abbou, Samuel, Allorant, Adrien, Valteau-Couanet, Dominique, Sarnacki, Sabine, Gamiche-Rolland, Louise, Meurice, Guillaume, Minard-Colin, Veronique, Grill, Jacques, Brugieres, Laurence, Dufour, Christelle, Gaspar, Nathalie, Michiels, Stefan, Vassal, Gilles, Soria, Jean-Charles, Geoerger, Birgit

“…This single-institutional feasibility study prospectively characterized genomic alterations in recurrent or refractory solid tumors of pediatric patients to…”
Get full text

Delays in diagnosis of paediatric cancers: a systematic review and comparison with expert testimony in lawsuits by Brasme, Jean-François, Dr, Morfouace, Michèle, Grill, Jacques, PhD, Martinot, Alain, Prof, Amalberti, René, Prof, Bons-Letouzey, Catherine, MD, Chalumeau, Martin, Prof

“…Summary Delayed diagnosis of paediatric cancers is reported regularly and is a source of remorse for physicians and parents and a leading cause of malpractice…”
Get full text

Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas by Puget, Stephanie, Philippe, Cathy, Bax, Dorine A, Job, Bastien, Varlet, Pascale, Junier, Marie-Pierre, Andreiuolo, Felipe, Carvalho, Dina, Reis, Ricardo, Guerrini-Rousseau, Lea, Roujeau, Thomas, Dessen, Philippe, Richon, Catherine, Lazar, Vladimir, Le Teuff, Gwenael, Sainte-Rose, Christian, Geoerger, Birgit, Vassal, Gilles, Jones, Chris, Grill, Jacques

“…Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain tumor and its prognosis is universaly fatal. No significant…”
Get full text

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging by Pagès, Mélanie, Pajtler, Kristian W., Puget, Stéphanie, Castel, David, Boddaert, Nathalie, Tauziède‐Espariat, Arnault, Picot, Stéphanie, Debily, Marie‐Anne, Kool, Marcel, Capper, David, Sainte‐Rose, Christian, Chrétien, Fabrice, Pfister, Stefan M., Pietsch, Torsten, Grill, Jacques, Varlet, Pascale, Andreiuolo, Felipe

“…Ependymoma with RELA fusion has been defined as a novel entity of the revised World Health Organization 2016 classification of tumors of the central nervous…”
Get full text

Survival and Prognostic Factors of Early Childhood Medulloblastoma: An International Meta-Analysis by RUTKOWSKI, Stefan, VON HOFF, Katja, GRUNDY, Richard G, FINLAY, Jonathan L, DHALL, Girish, RAQUIN, Marie-Anne, GRILL, Jacques, EMSER, Angela, ZWIENER, Isabella, PIETSCH, Torsten, FIGARELLA-BRANGER, Dominique, GIANGASPERO, Felice, ELLISON, David W, GARRE, Maria-Luisa, BIASSONI, Veronica

“…To assess the prognostic role of clinical parameters and histology in early childhood medulloblastoma. Clinical and histologic data from 270 children younger…”
Get full text

Pediatric craniopharyngiomas : classification and treatment according to the degree of hypothalamic involvement by PUGET, Stéphanie, GARNETT, Matthew, SAINTE-ROSE, Christian, WRAY, Alison, GRILL, Jacques, HABRAND, Jean-Louis, BODAERT, Nathalie, ZERAH, Michel, BEZERRA, Mercia, RENIER, Dominique, PIERRE-KAHN, Alain

“…The current treatment of craniopharyngiomas is evolving into one of a multimodal approach in which the aim is disease control and improved preservation of…”
Get full text

Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location by Castel, David, Philippe, Cathy, Kergrohen, Thomas, Sill, Martin, Merlevede, Jane, Barret, Emilie, Puget, Stéphanie, Sainte-Rose, Christian, Kramm, Christof M, Jones, Chris, Varlet, Pascale, Pfister, Stefan M, Grill, Jacques, Jones, David T W, Debily, Marie-Anne

“…Diffuse midline glioma (DMG), H3 K27M-mutant, is a new entity in the updated WHO classification grouping together diffuse intrinsic pontine gliomas and…”
Get full text

High Frequency of Germline SUFU Mutations in Children With Desmoplastic/Nodular Medulloblastoma Younger Than 3 Years of Age by Brugières, Laurence, Remenieras, Audrey, Pierron, Gaëlle, Varlet, Pascale, Forget, Sébastien, Byrde, Véronique, Bombled, Johny, Puget, Stéphanie, Caron, Olivier, Dufour, Christelle, Delattre, Olivier, Bressac-de Paillerets, Brigitte, Grill, Jacques

“…Germline mutations of the SUFU gene have been shown to be associated with genetic predisposition to medulloblastoma, mainly in families with multiple cases of…”
Get full text

Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma by Grill, Jacques, Puget, Stephanie, Andreiuolo, Felipe, Philippe, Cathy, MacConaill, Laura, Kieran, Mark W.

“…Diffuse intrinsic pontine gliomas (DIPG) can not be cured with current treatment modalities. Targeted therapy in this disease would benefit from advanced…”
Get full text

Craniopharyngioma by Garnett, Matthew R, Puget, Stéphanie, Grill, Jacques, Sainte-Rose, Christian

“…Craniopharyngiomas are benign slow growing tumours that are located within the sellar and para sellar region of the central nervous system. The point…”
Get full text

Clinicopathologic prognostic factors in childhood atypical teratoid and rhabdoid tumor of the central nervous system by Dufour, Christelle, Beaugrand, Annick, Le Deley, Marie Cécile, Bourdeaut, Franck, André, Nicolas, Leblond, Pierre, Bertozzi, Anne‐Isabelle, Frappaz, Didier, Rialland, Xavier, Fouyssac, Fanny, Edan, Christine, Grill, Jacques, Quidot, Marion, Varlet, Pascale

“…BACKGROUND: The objective of this study was to describe the clinical and pathologic features and to identify prognostic factors in patients with atypical…”
Get full text

Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts by Ellison, David W, Kocak, Mehmet, Figarella-Branger, Dominique, Felice, Giangaspero, Catherine, Godfraind, Pietsch, Torsten, Frappaz, Didier, Massimino, Maura, Grill, Jacques, Boyett, James M, Grundy, Richard G

“…Histopathological grading of ependymoma has been controversial with respect to its reproducibility and clinical significance. In a 3-phase study, we reviewed…”
Get full text

Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma by Zanello, Marc, Pages, Mélanie, Tauziède-Espariat, Arnault, Saffroy, Raphael, Puget, Stéphanie, Lacroix, Ludovic, Dezamis, Edouard, Devaux, Bertrand, Chrétien, Fabrice, Andreiuolo, Felipe, Sainte-Rose, Christian, Zerah, Michel, Dhermain, Frédéric, Dumont, Sarah, Louvel, Guillaume, Meder, Jean-François, Grill, Jacques, Dufour, Christelle, Pallud, Johan, Varlet, Pascale

“…Anaplastic ganglioglioma (AGG) is a rare and malignant variant of ganglioglioma. According to the World Health Organization classification version 2016, their…”
Get full text

Neurological hospitalisations in childhood cancer survivors treated before 2001: findings from the French Childhood Cancer Survivor Study cohort by Rajaonera, David, Bejarano-Quisoboni, Daniel, Grill, Jacques, Allodji, Rodrigue S, Pelletier-Fleury, Nathalie, Journy, Neige, Boussac, Marjorie, Doz, François, Vu-Bezin, Giao, Zidane, Monia, Schwartz, Boris, Haddy, Nadia, Bolle, Stéphanie, El-Fayech, Chiraz, Dufour, Christelle, Diallo, Ibrahima, Schleiermacher, Gudrun, Fresneau, Brice, de Vathaire, Florent

“…Childhood cancer survivors (CCS) have an increased risk of developing late chronic diseases, which can be influenced by the cancer type and its treatment…”
Get full text

Stereotactic biopsy of diffuse pontine lesions in children by ROUJEAU, Thomas, MACHADO, Guilherme, SAINTE-ROSE, Christian, GARNETT, Matthew R, MIQUEL, Catherine, PUGET, Stephanie, GEOERGER, Birgit, GRILL, Jacques, BODDAERT, Nathalie, DI ROCCO, Federico, ZERAH, Michel

“…Empirical radiotherapy is the current treatment for children with diffuse pontine lesions that have imaging characteristics of an infiltrative malignant…”
Get full text