Search Results - "Grill, Alex E"

Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1 by Schaefers, Matthew M, Breshears, Laura M, Anderson, Michele J, Lin, Ying-Chi, Grill, Alex E, Panyam, Jayanth, Southern, Peter J, Schlievert, Patrick M, Peterson, Marnie L

“…Staphylococcus aureus initiates infections and produces virulence factors, including superantigens (SAgs), at mucosal surfaces. The SAg, Toxic Shock Syndrome…”
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Folic Acid Functionalized Nanoparticles for Enhanced Oral Drug Delivery by Roger, Emilie, Kalscheuer, Stephen, Kirtane, Ameya, Guru, Bharath Raja, Grill, Alex E, Whittum-Hudson, Judith, Panyam, Jayanth

“…The oral absorption of drugs that have poor bioavailability can be enhanced by encapsulation in polymeric nanoparticles. Transcellular transport of…”
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Co-delivery of natural metabolic inhibitors in a self-microemulsifying drug delivery system for improved oral bioavailability of curcumin by Grill, Alex E., Koniar, Brenda, Panyam, Jayanth

“…In spite of its well-documented anticancer chemopreventive and therapeutic activity, the clinical development of curcumin has been limited by its poor oral…”
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Detecting and Imaging O-GlcNAc Sites Using Glycosyltransferases: A Systematic Approach to Study O-GlcNAc by Wu, Zhengliang L, Tatge, Timothy J, Grill, Alex E, Zou, Yonglong

“…O-GlcNAcylation is a reversible serine/threonine glycosylation for regulating protein activity and availability inside cells. In a given protein,…”
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Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis by Vevang, Karin R., Zhang, Lin, Grill, Alex E., Hatsukami, Dorothy K., Meier, Ellen, Nomura, Sarah Oppeneer, Robien, Kim, Peterson, Lisa A.

“…Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of…”
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Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer by Grill, Alex E., Shahani, Komal, Koniar, Brenda, Panyam, Jayanth

“…Curcumin has shown promising inhibitory activity against HER-2-positive tumor cells in vitro but suffers from poor oral bioavailability in vivo. Our lab has…”
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Individual Differences in the Response of Human β‑Lymphoblastoid Cells to the Cytotoxic, Mutagenic, and DNA-Damaging Effects of a DNA Methylating Agent, N‑Methylnitrosourethane by Peterson, Lisa A, Ignatovich, Igor V, Grill, Alex E, Beauchamp, Amanda, Ho, Yen-Yi, DiLernia, Andrew S, Zhang, Lin

“…Metabolic activation of many carcinogens leads to formation of reactive intermediates that form DNA adducts. These adducts are cytotoxic when they interfere…”
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Abundant Rodent Furan-Derived Urinary Metabolites Are Associated with Tobacco Smoke Exposure in Humans by Grill, Alex E, Schmitt, Thaddeus, Gates, Leah A, Lu, Ding, Bandyopadhyay, Dipankar, Yuan, Jian-Min, Murphy, Sharon E, Peterson, Lisa A

“…Furan, a possible human carcinogen, is found in heat treated foods and tobacco smoke. Previous studies have shown that humans are capable of converting furan…”
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Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice by Narayanapillai, Sreekanth C, Balbo, Silvia, Leitzman, Pablo, Grill, Alex E, Upadhyaya, Pramod, Shaik, Ahmad Ali, Zhou, Bo, O'Sullivan, M Gerard, Peterson, Lisa A, Lu, Junxuan, Hecht, Stephen S, Xing, Chengguo

“…We have previously shown that kava and its flavokavain-free Fraction B completely blocked 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung…”
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Interfacial Activity Assisted Surface Functionalization: A Novel Approach To Incorporate Maleimide Functional Groups and cRGD Peptide on Polymeric Nanoparticles for Targeted Drug Delivery by Toti, Udaya S, Guru, Bharath Raja, Grill, Alex E, Panyam, Jayanth

“…Nanoparticles formulated using poly(d,l-lactide-co-glycolide) (PLGA) copolymer have emerged as promising carriers for targeted delivery of a wide variety of…”
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Mutagenicity of furan in female Big Blue B6C3F1 mice by Terrell, Ashley N., Huynh, Mailee, Grill, Alex E., Kovi, Ramesh C., O'Sullivan, M. Gerard, Guttenplan, Joseph B., Ho, Yen-Yi, Peterson, Lisa A.

“…•Furan was tested in the Big Blue mouse model using two treatment regimens.•Transgene mutation frequency was not affected but GC to TA transversions…”
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