Search Results - "Grijalva, Victor"

Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis by Devarajan, Asokan, Bourquard, Noam, Hama, Susan, Navab, Mohamad, Grijalva, Victor R, Morvardi, Susan, Clarke, Catherine F, Vergnes, Laurent, Reue, Karen, Teiber, John F, Reddy, Srinivasa T

“…Increased production of reactive oxygen species (ROS) as a result of decreased activities of mitochondrial electron transport chain (ETC) complexes plays a…”
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HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock by Guirgis, Faheem W, Dodani, Sunita, Leeuwenburgh, Christiaan, Moldawer, Lyle, Bowman, Jennifer, Kalynych, Colleen, Grijalva, Victor, Reddy, Srinivasa T, Jones, Alan E, Moore, Frederick A

“…High density lipoprotein (HDL) is important for defense against sepsis but becomes dysfunctional (Dys-HDL) during inflammation. We hypothesize that Dys-HDL…”
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Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues by Singh, Rajan, Braga, Melissa, Reddy, Srinivasa T., Lee, Se-Jin, Parveen, Meher, Grijalva, Victor, Vergnes, Laurent, Pervin, Shehla

“…We previously demonstrated that Fst expression is highest in brown adipose tissue (BAT) and skeletal muscle, but is also present at substantial levels in…”
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A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes by Guirgis, Faheem W, Black, Lauren Page, Henson, Morgan, Labilloy, Guillaume, Smotherman, Carmen, Hopson, Charlotte, Tfirn, Ian, DeVos, Elizabeth L, Leeuwenburgh, Christiaan, Moldawer, Lyle, Datta, Susmita, Brusko, Todd M, Hester, Alexis, Bertrand, Andrew, Grijalva, Victor, Arango-Esterhay, Alexander, Moore, Frederick A, Reddy, Srinivasa T

“…Abstract Objective Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay…”
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Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation by Mukherjee, Pallavi, Chattopadhyay, Arnab, Grijalva, Victor, Dorreh, Nasrin, Lagishetty, Venu, Jacobs, Jonathan P., Clifford, Bethan L., Vallim, Thomas, Mack, Julia J., Navab, Mohamad, Reddy, Srinivasa T., Fogelman, Alan M.

“…We previously reported that adding a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F) to a Western diet (WD) ameliorated…”
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Role of PON2 in innate immune response in an acute infection model by Devarajan, Asokan, Bourquard, Noam, Grijalva, Victor R, Gao, Feng, Ganapathy, Ekambaram, Verma, Jitendra, Reddy, Srinivasa T.

“…N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL) is a quorum-sensing molecule produced by gram-negative microbial pathogens such as Pseudomonas aeruginosa…”
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Follistatin promotes adipocyte differentiation, browning, and energy metabolism[S] by Braga, Melissa, Reddy, Srinivasa T., Vergnes, Laurent, Pervin, Shehla, Grijalva, Victor, Stout, David, David, John, Li, Xinmin, Tomasian, Venina, Reid, Christopher B., Norris, Keith C., Devaskar, Sherin U., Reue, Karen, Singh, Rajan

“…Follistatin (Fst) functions to bind and neutralize the activity of members of the transforming growth factor-β superfamily. Fst has a well-established role in…”
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ApoA-I mimetics reduce systemic and gut inflammation in chronic treated HIV by Daskou, Maria, Mu, William, Sharma, Madhav, Vasilopoulos, Hariclea, Heymans, Rachel, Ritou, Eleni, Rezek, Valerie, Hamid, Philip, Kossyvakis, Athanasios, Sen Roy, Shubhendu, Grijalva, Victor, Chattopadhyay, Arnab, Kitchen, Scott G, Fogelman, Alan M, Reddy, Srinivasa T, Kelesidis, Theodoros

“…Novel therapeutic strategies are needed to attenuate increased systemic and gut inflammation that contribute to morbidity and mortality in chronic HIV…”
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Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer by Su, Feng, Kozak, Kathy R., Imaizumi, Satoshi, Gao, Feng, Amneus, Malaika W., Grijalva, Victor, Ng, Carey, Wagner, Alan, Hough, Greg, Farias-Eisner, Gina, Anantharamaiah, G. M., Van Lenten, Brian J., Navab, Mohamad, Fogelman, Alan M., Reddy, Srinivasa T., Farias-Eisner, Robin, Patel, C. Kumar N.

“…We examined whether reduced levels of Apolipoprotein A-I (apoA-I) in ovarian cancer patients are causal in ovarian cancer in a mouse model. Mice expressing a…”
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Suppression of inflammatory arthritis in human serum paraoxonase 1 transgenic mice by Charles-Schoeman, Christina, Wang, Jennifer, Shahbazian, Ani, Lee, Yuen Yin, Wang, Xiaoyan, Grijalva, Victor, Brahn, Ernest, Shih, Diana M., Devarajan, Asokan, Montano, Christy, Lusis, Aldons J., Reddy, Srinivasa T.

“…Paraoxonase 1(PON1) is an HDL-associated protein, which metabolizes inflammatory, oxidized lipids associated with atherosclerotic plaque development. Because…”
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A novel approach to oral apoA-I mimetic therapy[S] by Chattopadhyay, Arnab, Navab, Mohamad, Hough, Greg, Gao, Feng, Meriwether, David, Grijalva, Victor, Springstead, James R., Palgnachari, Mayakonda N., Namiri-Kalantari, Ryan, Su, Feng, Van Lenten, Brian J., Wagner, Alan C., Anantharamaiah, G.M., Farias-Eisner, Robin, Reddy, Srinivasa T., Fogelman, Alan M.

“…Transgenic tomato plants were constructed with an empty vector (EV) or a vector expressing an apoA-I mimetic peptide, 6F. EV or 6F tomatoes were harvested,…”
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Role of enterocyte stearoyl-Co-A desaturase-1 in LDLR-null mice by Mukherjee, Pallavi, Hough, Greg, Chattopadhyay, Arnab, Grijalva, Victor, O'Connor, Ellen Ines, Meriwether, David, Wagner, Alan, Ntambi, James M., Navab, Mohamad, Reddy, Srinivasa T., Fogelman, Alan M.

“…After crossing floxed stearoyl-CoA desaturase-1 (Scd1fl/fl) mice with LDL receptor-null (ldlr−/−) mice, and then Villin Cre (VilCre) mice, enterocyte Scd1…”
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Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis by Navab, Mohamad, Chattopadhyay, Arnab, Hough, Greg, Meriwether, David, Fogelman, Spencer I., Wagner, Alan C., Grijalva, Victor, Su, Feng, Anantharamaiah, G.M., Hwang, Lin H., Faull, Kym F., Reddy, Srinivasa T., Fogelman, Alan M.

“…We previously reported that i) a Western diet increased levels of unsaturated lysophosphatidic acid (LPA) in small intestine and plasma of LDL receptor null…”
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Apolipoprotein A-I Mimetic Peptides Prevent Atherosclerosis Development and Reduce Plaque Inflammation in a Murine Model of Diabetes by MORGANTINI, Cecilia, IMAIZUMI, Satoshi, GRIJALVA, Victor, NAVAB, Mohamad, FOGELMAN, Alan M, REDDY, Srinivasa T

“…To determine the effect of the apolipoprotein A-I (ApoA-I) mimetic peptide, D-4F, on atherosclerosis development in a pre-existing diabetic condition. We…”
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HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer by Su, Feng, Grijalva, Victor, Navab, Kaveh, Ganapathy, Ekambaram, Meriwether, David, Imaizumi, Satoshi, Navab, Mohamad, Fogelman, Alan M, Reddy, Srinivasa T, Farias-Eisner, Robin

“…Recent studies suggest that high-density lipoprotein (HDL) levels are inversely related to colon cancer risk. HDL mimetics constructed from a number of…”
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Hemoglobin and Its Scavenger Protein Haptoglobin Associate with ApoA-1-containing Particles and Influence the Inflammatory Properties and Function of High Density Lipoprotein by Watanabe, Junji, Grijalva, Victor, Hama, Susan, Barbour, Karen, Berger, Franklin G., Navab, Mohamad, Fogelman, Alan M., Reddy, Srinivasa T.

“…Hemoglobin (Hb) uniquely associates with proinflammatory HDL in atherogenic mice and coronary heart disease (CHD) patients. In this paper, we report that Hb…”
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Apolipoprotein A-I Mimetic Peptides by Navab, Mohamad, Anantharamaiah, G M, Reddy, Srinivasa T, Hama, Susan, Hough, Greg, Grijalva, Victor R, Yu, Nicholas, Ansell, Benjamin J, Datta, Geeta, Garber, David W, Fogelman, Alan M

“…Despite identical amino acid composition, differences in class A amphipathic helical peptides caused by differences in the order of amino acids on the…”
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Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid[S] by Navab, Mohamad, Hough, Greg, Buga, Georgette M., Su, Feng, Wagner, Alan C., Meriwether, David, Chattopadhyay, Arnab, Gao, Feng, Grijalva, Victor, Danciger, Janet S., Van Lenten, Brian J., Org, Elin, Lusis, Aldons J., Pan, Calvin, Anantharamaiah, G.M., Farias-Eisner, Robin, Smyth, Susan S., Reddy, Srinivasa T., Fogelman, Alan M.

“…We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic…”
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D-4F, an apoA-I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the antioxidant enzyme MnSOD by Ganapathy, Ekambaram, Su, Feng, Meriwether, David, Devarajan, Asokan, Grijalva, Victor, Gao, Feng, Chattopadhyay, Arnab, Anantharamaiah, G.M., Navab, Mohamad, Fogelman, Alan M., Reddy, Srinivasa T., Farias-Eisner, Robin

“…We recently reported that apoA‐I and apoA‐I mimetic peptides prevent the development of flank tumors in immunocompetent C57BL/6J mice. To delineate the…”
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Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux[S] by Meriwether, David, Sulaiman, Dawoud, Wagner, Alan, Grijalva, Victor, Kaji, Izumi, Williams, Kevin J., Yu, Liqing, Fogelman, Spencer, Volpe, Carmen, Bensinger, Steven J., Anantharamaiah, G.M., Shechter, Ishaiahu, Fogelman, Alan M., Reddy, Srinivasa T.

“…The site and mechanism of action of the apoA-I mimetic peptide 4F are incompletely understood. Transintestinal cholesterol efflux (TICE) is a process involved…”
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