Search Results - "Griggs, Ryan B"

Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes by Griggs, Ryan B., Santos, Diogo F., Laird, Don E., Doolen, Suzanne, Donahue, Renee R., Wessel, Caitlin R., Fu, Weisi, Sinha, Ghanshyam P., Wang, Pingyuan, Zhou, Jia, Brings, Sebastian, Fleming, Thomas, Nawroth, Peter P., Susuki, Keiichiro, Taylor, Bradley K.

“…Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes. Methylglyoxal (MG) is a reactive metabolite whose elevation in the…”
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Formation and disruption of functional domains in myelinated CNS axons by Griggs, Ryan B., Yermakov, Leonid M., Susuki, Keiichiro

“…•Intrinsic axonal mechanisms regulate axon initial segment formation.•Myelination regulates node of Ranvier formation and mitochondrial distribution.•Calpains…”
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Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation by Griggs, Ryan B, Laird, Don E, Donahue, Renee R, Fu, Weisi, Taylor, Bradley K

“…Methylglyoxal (MG) is a metabolite of glucose that may contribute to peripheral neuropathy and pain in diabetic patients. MG increases intracellular calcium in…”
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The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels by Griggs, Ryan B, Nguyen, Duc V M, Yermakov, Leonid M, Jaber, Jeneane M, Shelby, Jennae N, Steinbrunner, Josef K, Miller, John A, Gonzalez-Islas, Carlos, Wenner, Peter, Susuki, Keiichiro

“…Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or location along the axon) contributes to CNS dysfunction in…”
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Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation by Griggs, Ryan B., Yermakov, Leonid M., Drouet, Domenica E., Nguyen, Duc V.M., Susuki, Keiichiro

“…Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central…”
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Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice by Yermakov, Leonid M, Drouet, Domenica E, Griggs, Ryan B, Elased, Khalid M, Susuki, Keiichiro

“…Cognitive and mood impairments are common central nervous system complications of type 2 diabetes, although the neuronal mechanism(s) remains elusive. Previous…”
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Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms by Griggs, Ryan B., Donahue, Renee R., Morgenweck, Jenny, Grace, Peter M., Sutton, Amanda, Watkins, Linda R., Taylor, Bradley K.

“…Repeated administration of peroxisome proliferator-activated receptor gamma (PPARγ) agonists reduces neuropathic pain-like behavior and associated changes in…”
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Impairment of cognitive flexibility in type 2 diabetic db/db mice by Yermakov, Leonid M., Griggs, Ryan B., Drouet, Domenica E., Sugimoto, Chiho, Williams, Michael T., Vorhees, Charles V., Susuki, Keiichiro

“…•Type 2 diabetic db/db mice show impaired cognitive flexibility.•Immobility and slow swim speed in db/db mice may affect behavioral outcomes.•Path efficiency…”
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Gabapentin alleviates affective pain after traumatic nerve injury by Griggs, Ryan B, Bardo, Michael T, Taylor, Bradley K

“…Gabapentin reduces behavioral signs of stimulus-evoked allodynia and hyperalgesia in preclinical studies of traumatic nerve injury, but its effects on more…”
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Glial βII Spectrin Contributes to Paranode Formation and Maintenance by Susuki, Keiichiro, Zollinger, Daniel R, Chang, Kae-Jiun, Zhang, Chuansheng, Huang, Claire Yu-Mei, Tsai, Chang-Ru, Galiano, Mauricio R, Liu, Yanhong, Benusa, Savannah D, Yermakov, Leonid M, Griggs, Ryan B, Dupree, Jeffrey L, Rasband, Matthew N

“…Action potential conduction along myelinated axons depends on high densities of voltage-gated Na channels at the nodes of Ranvier. Flanking each node,…”
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Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes by Griggs, Ryan B, Donahue, Renee R, Adkins, Braxton G, Anderson, Katie L, Thibault, Olivier, Taylor, Bradley K

“…Thiazolidinedione drugs (TZDs) such as pioglitazone are approved by the U.S. Food and Drug Administration for the treatment of insulin resistance in type 2…”
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Functional Domains in Myelinated Axons by Yermakov, Leonid M, Hong, Lulu A, Drouet, Domenica E, Griggs, Ryan B, Susuki, Keiichiro

“…Propagation of action potentials along axons is optimized through interactions between neurons and myelinating glial cells. Myelination drives division of the…”
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Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca(2+) biomarkers of aging by Maimaiti, Shaniya, DeMoll, Chris, Anderson, Katie L, Griggs, Ryan B, Taylor, Bradley K, Porter, Nada M, Thibault, Olivier

“…Results from clinical studies provide evidence that cognitive changes relatively late in life may be traced to antecedent conditions including diabetes,…”
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Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca2+ biomarkers of aging by Maimaiti, Shaniya, DeMoll, Chris, Anderson, Katie L, Griggs, Ryan B, Taylor, Bradley K, Porter, Nada M, Thibault, Olivier

“…Abstract Results from clinical studies provide evidence that cognitive changes relatively late in life may be traced to antecedent conditions including…”
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Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca 2+ biomarkers of aging by Maimaiti, Shaniya, DeMoll, Chris, Anderson, Katie L., Griggs, Ryan B., Taylor, Bradley K., Porter, Nada M., Thibault, Olivier

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Pioglitazone rapidly reduces neuropathic pain through astrocyte and non-genomic PPARγ mechanisms by Griggs, Ryan B., Donahue, Renee R., Morgenweck, Jenny, Grace, Peter M., Sutton, Amanda, Watkins, Linda R., Taylor, Bradley K.

“…Repeated administration of peroxisome proliferator-activated receptor gamma (PPARγ) agonists reduces neuropathic pain-like behavior and associated changes in…”
Get full text

Targeting Methylglyoxal and PPAR Gamma to Alleviate Neuropathic Pain Associated with Type 2 Diabetes by Griggs, Ryan B

“…Neuropathic pain affects up to 50% of the 29 million diabetic patients in the United States. Neuropathic pain in diabetes manifests as a disease of the…”
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