Search Results - "Grigaitis, Pranas"

Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies by Elsemman, Ibrahim E., Rodriguez Prado, Angelica, Grigaitis, Pranas, Garcia Albornoz, Manuel, Harman, Victoria, Holman, Stephen W., van Heerden, Johan, Bruggeman, Frank J., Bisschops, Mark M. M., Sonnenschein, Nikolaus, Hubbard, Simon, Beynon, Rob, Daran-Lapujade, Pascale, Nielsen, Jens, Teusink, Bas

“…When conditions change, unicellular organisms rewire their metabolism to sustain cell maintenance and cellular growth. Such rewiring may be understood as…”
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A Computational Toolbox to Investigate the Metabolic Potential and Resource Allocation in Fission Yeast by Grigaitis, Pranas, Grundel, Douwe A J, van Pelt-KleinJan, Eunice, Isaku, Mirushe, Xie, Guixiang, Mendoza Farias, Sebastian, Teusink, Bas, van Heerden, Johan H

“…The fission yeast, Schizosaccharomyces pombe, is a popular eukaryal model organism for cell division and cell cycle studies. With this extensive knowledge of…”
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Epistatic Analysis of the Contribution of Rabs and Kifs to CATCHR Family Dependent Golgi Organization by Liu, Shijie, Majeed, Waqar, Grigaitis, Pranas, Betts, Matthew J, Climer, Leslie K, Starkuviene, Vytaute, Storrie, Brian

“…Multisubunit members of the CATCHR family: COG and NRZ complexes, mediate intra-Golgi and Golgi to ER vesicle tethering, respectively. We systematically…”
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An excess of glycolytic enzymes under glucose‐limited conditions may enable Saccharomyces cerevisiae to adapt to nutrient availability by Grigaitis, Pranas, Teusink, Bas

“…Microorganisms, including the budding yeast Saccharomyces cerevisiae, express glycolytic proteins to a maximal capacity that (largely) exceeds the actual flux…”
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Transcription activation is enhanced by multivalent interactions independent of phase separation by Trojanowski, Jorge, Frank, Lukas, Rademacher, Anne, Mücke, Norbert, Grigaitis, Pranas, Rippe, Karsten

“…Transcription factors (TFs) consist of a DNA-binding domain and an activation domain (AD) that are frequently considered to be independent and exchangeable…”
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Protein cost allocation explains metabolic strategies in Escherichia coli by Grigaitis, Pranas, Olivier, Brett G., Fiedler, Tomas, Teusink, Bas, Kummer, Ursula, Veith, Nadine

“…•A novel framework for genome-scale models is developed to improve the predictability.•The new framework includes protein expression and turnover costs and…”
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Use and limitations of genome-scale metabolic models in food microbiology by Somerville, Vincent, Grigaitis, Pranas, Battjes, Julius, Moro, Francesco, Teusink, Bas

“…•Computational models are a useful tool to understand microbial metabolism.•Challenges are complex media and interactions between metabolically diverse…”
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Lysosome-targeted photodynamic treatment induces primary keratinocyte differentiation by Daugelaviciene, Neringa, Grigaitis, Pranas, Gasiule, Liepa, Dabkeviciene, Daiva, Neniskyte, Urte, Sasnauskiene, Ausra

“…Photodynamic therapy is an attractive technique for various skin tumors and non-cancerous skin lesions. However, while the aim of photodynamic therapy is to…”
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Elevated energy costs of biomass production in mitochondrial respiration-deficient Saccharomyces cerevisia by Grigaitis, Pranas, van den Bogaard, Samira L, Teusink, Bas

“…Microbial growth requires energy for maintaining the existing cells and producing components for the new ones. Microbes therefore invest a considerable amount…”
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Elevated energy costs of biomass production in mitochondrial respiration-deficient Saccharomyces cerevisiae by Grigaitis, Pranas, van den Bogaard, Samira L, Teusink, Bas

“…Abstract Microbial growth requires energy for maintaining the existing cells and producing components for the new ones. Microbes therefore invest a…”
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The role of interleukin-8 (CXCL8) and CXCR2 in acquired chemoresistance of human colorectal carcinoma cells HCT116 by Dabkeviciene, Daiva, Jonusiene, Violeta, Zitkute, Vilmante, Zalyte, Egle, Grigaitis, Pranas, Kirveliene, Vida, Sasnauskiene, Ausra

“…Colorectal cancer is one of the most common malignant diseases and is a leading cause of cancer mortality in the Western world. Primary or acquired resistance…”
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Exogenous interleukin-1α signaling negatively impacts acquired chemoresistance and alters cell adhesion molecule expression pattern in colorectal carcinoma cells HCT116 by Grigaitis, Pranas, Jonusiene, Violeta, Zitkute, Vilmante, Dapkunas, Justas, Dabkeviciene, Daiva, Sasnauskiene, Ausra

“…•Exogenous IL-1α-pretreated HCT116 cells are more sensitive to 5-fluorouracil (5-FU).•IL-1α-pretreatment also increases chemosensitivity of a 5-FU-resistant…”
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miRNA target identification and prediction as a function of time in gene expression data by Grigaitis, Pranas, Starkuviene, Vytaute, Rost, Ursula, Serva, Andrius, Pucholt, Pascal, Kummer, Ursula

“…The understanding of miRNA target interactions is still limited due to conflicting data and the fact that high-quality validation of targets is a…”
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