Search Results - "Griffiths, R. J"

Grain Size Hardening in Mg and Mg-Zn Solid Solutions by Caceres, C. H., Mann, Gemma E., Griffiths, J. R.

“…Cast specimens of Mg and of several Mg-Zn binary alloys with a wide range of grain sizes were deformed in tension and compression. The k values calculated from…”
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Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations by Pollard, P.J., Brière, J.J., Alam, N.A., Barwell, J., Barclay, E., Wortham, N.C., Hunt, T., Mitchell, M., Olpin, S., Moat, S.J., Hargreaves, I.P., Heales, S.J., Chung, Y.L., Griffiths, J.R., Dalgleish, A., McGrath, J.A., Gleeson, M.J., Hodgson, S.V., Poulsom, R., Rustin, P., Tomlinson, I.P.M.

“…The nuclear-encoded Krebs cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDHB, -C and -D), act as tumour suppressors. Germline mutations…”
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Dichloroacetate induces autophagy in colorectal cancer cells and tumours by Lin, G, Hill, D K, Andrejeva, G, Boult, J K R, Troy, H, Fong, A-C L F W T, Orton, M R, Panek, R, Parkes, H G, Jafar, M, Koh, D-M, Robinson, S P, Judson, I R, Griffiths, J R, Leach, M O, Eykyn, T R, Chung, Y-L

“…Background: Dichloroacetate (DCA) has been found to have antitumour properties. Methods: We investigated the cellular and metabolic responses to DCA treatment…”
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Dynamic asymmetry of phosphocreatine concentration and O2 uptake between the on- and off-transients of moderate- and high-intensity exercise in humans by Rossiter, H. B., Ward, S. A., Kowalchuk, J. M., Howe, F. A., Griffiths, J. R., Whipp, B. J.

“…The on- and off-transient (i.e. phase II) responses of pulmonary oxygen uptake ( V̇ O 2 ) to moderate-intensity exercise (i.e. below the lactate threshold, θ…”
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The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations by LEACH, Mo, BRINDLE, Km, MCINTYRE, D, PADHANI, Ar, PRICE, P, RATHBONE, R, RUSTIN, Gj, TOFTS, Ps, TOZER, Gm, VENNART, W, WATERTON, Jc, WILLIAMS, Sr, EVELHOCH, Jl, WORKMAN, P, GRIFFITHS, Jr, HORSMAN, Mr, JACKSON, A, JAYSON, Gc, JUDSON, Ir, KNOPP, Mv, MAXWELL, Rj

“…Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used…”
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Reversible plastic strain during cyclic loading–unloading of Mg and Mg–Zn alloys by Mann, G.E., Sumitomo, T., Cáceres, C.H., Griffiths, J.R.

“…Large hysteresis loops are observed during cyclic loading–unloading of Mg and Mg–Zn alloys. This is true for both tension and compression cycling, for grain…”
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Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo by Bapiro, T E, Frese, K K, Courtin, A, Bramhall, J L, Madhu, B, Cook, N, Neesse, A, Griffiths, J R, Tuveson, D A, Jodrell, D I, Richards, F M

“…Background: The modest benefits of gemcitabine (dFdC) therapy in patients with pancreatic ductal adenocarcinoma (PDAC) are well documented, with drug delivery…”
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Taurine: a potential marker of apoptosis in gliomas by Opstad, K S, Bell, B A, Griffiths, J R, Howe, F A

“…New cancer therapies are being developed that trigger tumour apoptosis and an in vivo method of apoptotic detection and early treatment response would be of…”
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Oxide films, pores and the fatigue lives of cast aluminum alloys by WANG, Q. G, DAVIDSON, C. J, GRIFFITHS, J. R, CREPEAU, P. N

“…In the absence of gross defects such as cold shuts, the fatigue properties of castings are largely determined by the sizes of microstructural defects,…”
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Effects of solidification rate and ageing on the microstructure and mechanical properties of AZ91 alloy by Cáceres, C.H, Davidson, C.J, Griffiths, J.R, Newton, C.L

“…Sand-cast plates of a commercial AZ91C alloy have been used for the study. Varying the solidification rate by placing large cast-iron chills in the mould…”
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Damage by eutectic particle cracking in aluminum casting alloys A356/357 by WANG, Q. G, CACERES, C. H, GRIFFITHS, J. R

“…The strain dependence of particle cracking in aluminum alloys A356/357 in the T6 temper has been studied in a range of microstructures produced by varying…”
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Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high-intensity knee-extension exercise in humans by Rossiter, H. B., Ward, S. A., Kowalchuk, J. M., Howe, F. A., Griffiths, J. R., Whipp, B. J.

“…A prior bout of high-intensity square-wave exercise can increase the temporal adaptation of pulmonary oxygen uptake ( ) to a subsequent bout of high-intensity…”
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Microhardness mapping and the hardness-yield strength relationship in high-pressure diecast magnesium alloy AZ91 by Cáceres, C.H., Griffiths, J.R., Pakdel, A.R., Davidson, C.J.

“…Microhardness maps of cross-sections of high-pressure diecast test bars of AZ91 have been determined. Specimens with rectangular cross-sections, 1, 2 and 3 mm…”
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Are cancer cells acidic? by GRIFFITHS, J. R

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Hall-Petch parameters in tension and compression in cast Mg–2Zn alloys by Mann, G., Griffiths, J.R., Cáceres, C.H.

“…The flow stress in tension and compression has been measured as a function of plastic strain in Mg–2Zn castings with grain sizes ranging from 55 to 340 μm…”
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Do junior doctors know where to insert chest drains safely? by Griffiths, J R, Roberts, N

“…Background: The safe insertion of a chest drain is a skill doctors across specialties require. Incorrect placement can lead to significant morbidity and even…”
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Inferences from pulmonary O2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans by Rossiter, H. B., Ward, S. A., Doyle, V. L., Howe, F. A., Griffiths, J. R., Whipp, B. J.

“…In the non-steady state of moderate intensity exercise, pulmonary O 2 uptake ( V̇ p,O 2 ) is temporally dissociated from muscle O 2 consumption ( V̇ m,O 2 )…”
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Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours by Howe, F. A., Robinson, S. P., McIntyre, D. J. O., Stubbs, M., Griffiths, J. R.

“…The sensitivity of blood oxygenation level dependent (BOLD) contrast techniques to changes to tumour deoxyhaemoglobin concentration is of relevance to many…”
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Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging by ROBINSON, S. P, MCINTYRE, D. J. O, CHECKLEY, D, TESSIER, J. J, HOWE, F. A, GRIFFITHS, J. R, ASHTON, S. E, RYAN, A. J, BLAKEY, D. C, WATERTON, J. C

“…ZD6126 is a vascular targeting agent that disrupts the tubulin cytoskeleton of proliferating neo-endothelial cells. This leads to the selective destruction and…”
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Oxidative β-C-H sulfonylation of cyclic amines by Griffiths, R J, Kong, W C, Richards, S A, Burley, G A, Willis, M C, Talbot, E P A

“…A transition metal-free strategy for the dehydrogenative β-sulfonylation of tertiary cyclic amines is described. -Iodosuccinimide facilitates regioselective…”
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