Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy

Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, par...

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Bibliographic Details
Published in:	Movement disorders Vol. 21; no. 2; pp. 199 - 207
Main Authors:	Millar, David, Griffiths, Philipa, Zermansky, Adam J., Burn, David J.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-02-2006 Wiley
Subjects:	Affective Symptoms - diagnosis Affective Symptoms - physiopathology Affective Symptoms - psychology Aged Attention - physiology Awareness - physiology Biological and medical sciences Cognition Disorders - diagnosis Cognition Disorders - physiopathology Cognition Disorders - psychology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes dysexecutive syndrome Female Frontal Lobe - physiopathology Gyrus Cinguli - physiopathology Humans Katz Adjustment Scale-Relatives Male Medical sciences Mental Disorders - diagnosis Mental Disorders - physiopathology Mental Disorders - psychology Middle Aged Nervous system (semeiology, syndromes) Neurologic Examination Neurology Neuropsychological Tests Personality Assessment Prefrontal Cortex - physiopathology Problem Solving - physiology PSP Reaction Time - physiology Set (Psychology) Supranuclear Palsy, Progressive - diagnosis Supranuclear Palsy, Progressive - physiopathology Supranuclear Palsy, Progressive - psychology Verbal Behavior - physiology Nervous system diseases Katz Adjustment Scale-Relatives dysexecutive syndrome Adjustment PSP
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Summary:	Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale‐Relatives (KAS‐R), an instrument first developed to assess dysexecutive changes in head‐injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS‐R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease. © 2005 Movement Disorder Society
Bibliography:	istex:306C063732AF9B8B5021274C2DEF55FB04C5E7E7 PSP (Europe) Association ark:/67375/WNG-3PDVP5ZL-R ArticleID:MDS20707 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0885-3185 1531-8257
DOI:	10.1002/mds.20707