Search Results - "Griffiths, Gary L."

Near-Infrared Photoimmunotherapy: Photoactivatable Antibody–Drug Conjugates (ADCs) by Kobayashi, Hisataka, Griffiths, Gary L, Choyke, Peter L

“…Cancer treatment has been founded traditionally on the three approaches of surgery, radiation, and chemotherapy with the latter recognized as the obvious…”
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Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol[S] by Zhu, Xuewei, Owen, John S., Wilson, Martha D., Li, Haitao, Griffiths, Gary L., Thomas, Michael J., Hiltbold, Elizabeth M., Fessler, Michael B., Parks, John S.

“…We previously showed that macrophages from macrophage-specific ATP-binding cassette transporter A1 (ABCA1) knockout (Abca1-M/-M) mice had an enhanced…”
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Salivary excretion of systemically injected [ 18 F]DCFPyL in prostate cancer patients undergoing PSMA scans by Fernandes, Bruna, Roy, Jyoti, Basuli, Falguni, Warner, Blake M, Lindenberg, Liza, Mena, Esther, Adler, Steven S, Griffiths, Gary L, Choyke, Peter L, Lin, Frank I

“…Prostate-specific membrane antigen (PSMA) is present in high amounts in salivary glands, but it is unclear whether labeled binders of PSMA are excreted in the…”
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Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors by Sarin, Hemant, Kanevsky, Ariel S, Wu, Haitao, Sousa, Alioscka A, Wilson, Colin M, Aronova, Maria A, Griffiths, Gary L, Leapman, Richard D, Vo, Howard Q

“…The existence of large pores in the blood-tumor barrier (BTB) of malignant solid tumor microvasculature makes the blood-tumor barrier more permeable to…”
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Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells by Sarin, Hemant, Kanevsky, Ariel S, Wu, Haitao, Brimacombe, Kyle R, Fung, Steve H, Sousa, Alioscka A, Auh, Sungyoung, Wilson, Colin M, Sharma, Kamal, Aronova, Maria A, Leapman, Richard D, Griffiths, Gary L, Hall, Matthew D

“…Effective transvascular delivery of nanoparticle-based chemotherapeutics across the blood-brain tumor barrier of malignant gliomas remains a challenge. This is…”
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Near-Infrared Fluorescence Lifetime pH-Sensitive Probes by Berezin, Mikhail Y., Guo, Kevin, Akers, Walter, Northdurft, Ralph E., Culver, Joseph P., Teng, Bao, Vasalatiy, Olga, Barbacow, Kyle, Gandjbakhche, Amir, Griffiths, Gary L., Achilefu, Samuel

“…We report what we believe to be the first near-infrared pH-sensitive fluorescence lifetime molecular probe suitable for biological applications in…”
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Preparation and long-term biodistribution studies of a PAMAM dendrimer G5-Gd-BnDOTA conjugate for lymphatic imaging by Opina, Ana Christina, Wong, Karen J, Griffiths, Gary L, Turkbey, Baris I, Bernardo, Marcelino, Nakajima, Takahito, Kobayashi, Hisataka, Choyke, Peter L, Vasalatiy, Olga

“…To demonstrate the use of gadolinium (Gd)-labeled dendrimers as lymphatic imaging agents and establish the long-term biodistribution (90-day) of this type of…”
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Tracking the luminal exposure and lymphatic drainage pathways of intravaginal and intrarectal inocula used in nonhuman primate models of HIV transmission by Smedley, Jeremy, Turkbey, Baris, Bernardo, Marcelino L, Del Prete, Gregory Q, Estes, Jacob D, Griffiths, Gary L, Kobayashi, Hisataka, Choyke, Peter L, Lifson, Jeffrey D, Keele, Brandon F

“…Over 80% of sexual HIV-1 transmissions originate from a single viral variant, but the underlying basis for this transmission bottleneck remains to be…”
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Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent by Hyodo, Fuminori, Chuang, Kai-Hsiang, Goloshevsky, Artem G, Sulima, Agnieszka, Griffiths, Gary L, Mitchell, James B, Koretsky, Alan P, Krishna, Murali C

“…Reactive oxygen species (ROS) and compromised antioxidant defense may contribute to brain disorders such as stroke, amyotrophic lateral sclerosis, etc…”
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Anti-CD74 Antibody-Doxorubicin Conjugate, IMMU-110, in a Human Multiple Myeloma Xenograft and in Monkeys by Sapra, Puja, Stein, Rhona, Pickett, Jennifer, Qu, Zhengxing, Govindan, Serengulam V, Cardillo, Thomas M, Hansen, Hans J, Horak, Ivan D, Griffiths, Gary L, Goldenberg, David M

“…Purpose: IMMU-110 is a drug immunoconjugate composed of doxorubicin conjugated to the humanized anti-CD74 monoclonal antibody, hLL1, at a…”
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Development of a MR-Visible Compound for Tracing Neuroanatomical Connections In Vivo by Wu, Carolyn W.-H., Vasalatiy, Olga, Liu, Ning, Wu, Haitao, Cheal, Sarah, Chen, Der-Yow, Koretsky, Alan P., Griffiths, Gary L., Tootell, Roger B.H., Ungerleider, Leslie G.

“…Traditional studies of neuroanatomical connections require injection of tracer compounds into living brains, then histology of the postmortem tissue. Here, we…”
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(89)Zr-Oxine Complex PET Cell Imaging in Monitoring Cell-based Therapies by Sato, Noriko, Wu, Haitao, Asiedu, Kingsley O, Szajek, Lawrence P, Griffiths, Gary L, Choyke, Peter L

“…To develop a clinically translatable method of cell labeling with zirconium 89 ((89)Zr) and oxine to track cells with positron emission tomography (PET) in…”
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Translating a radiolabeled imaging agent to the clinic by Griffiths, Gary L., Vasquez, Crystal, Escorcia, Freddy, Clanton, Jeff, Lindenberg, Liza, Mena, Esther, Choyke, Peter L.

“…[Display omitted] Molecular Imaging is entering the most fruitful, exciting period in its history with many new agents under development, and several reaching…”
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Preclinical Imaging of Prostate Cancer by Olkowski, Colleen, Fernandes, Bruna, Griffiths, Gary L., Lin, Frank, Choyke, Peter L.

“…Prostate cancer remains a major cause of mortality and morbidity, affecting millions of men, with a large percentage expected to develop the disease as they…”
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Cure of SCID Mice Bearing Human B-Lymphoma Xenografts by an Anti-CD74 Antibody-Anthracycline Drug Conjugate by GRIFFITHS, Gary L, MATTES, M. Jules, STEIN, Rhona, GOVINDAN, Serengulam V, HORAK, Ivan D, HANSEN, Hans J, GOLDENBERG, David M

“…Purpose: The purpose of this research was to test the therapeutic efficacy of an anthracycline-antibody conjugate for the treatment of human B-cell lymphoma in…”
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Correction: Tracking the Luminal Exposure and Lymphatic Drainage Pathways of Intravaginal and Intrarectal Inocula Used in Nonhuman Primate Models of HIV Transmission by Smedley, Jeremy, Turkbey, Baris, Bernardo, Marcelino L, Del Prete, Gregory Q, Estes, Jacob D, Griffiths, Gary L, Kobayashi, Hisataka, Choyke, Peter L, Lifson, Jeffrey D, Keele, Brandon F

“…[This corrects the article DOI: 10.1371/journal.pone.0092830.]…”
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A Phase I Dosing Study of Ferumoxytol for MR Lymphography at 3 T in Patients With Prostate Cancer by Turkbey, Baris, Agarwal, Harsh K, Shih, Joanna, Bernardo, Marcelino, McKinney, Yolanda L, Daar, Dagane, Griffiths, Gary L, Sankineni, Sandeep, Johnson, Linda, Grant, Kinzya B, Weaver, Juanita, Rais-Bahrami, Soroush, Harisinghani, Mukesh, Jacobs, Paula, Dahut, William, Merino, Maria J, Pinto, Peter A, Choyke, Peter L

“…The objective of our study was to determine the optimal dose of ferumoxytol for performing MR lymphography (MRL) at 3 T in patients with prostate cancer. This…”
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Optimizing Bispecific Antibody Pretargeting for Use in Radioimmunotherapy by Sharkey, Robert M, Karacay, Habibe, Richel, Heidi, McBride, William J, Rossi, Edmund A, Chang, Ken, Yeldell, Dion, Griffiths, Gary L, Hansen, Hans J, Goldenberg, David M

“…Purpose: With increasing interest in pretargeting procedures for improving the delivery of radionuclides for cancer imaging and therapy, this investigation was…”
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Inhibition of Glutathione Peroxidase Mediates the Collateral Sensitivity of Multidrug-resistant Cells to Tiopronin by Hall, Matthew D., Marshall, Travis S., Kwit, Alexandra D.T., Miller Jenkins, Lisa M., Dulcey, Andrés E., Madigan, James P., Pluchino, Kristen M., Goldsborough, Andrew S., Brimacombe, Kyle R., Griffiths, Gary L., Gottesman, Michael M.

“…Multidrug resistance (MDR) is a major obstacle to the successful chemotherapy of cancer. MDR is often the result of overexpression of ATP-binding cassette…”
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Correction: Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin by Hall, Matthew D., Marshall, Travis S., Kwit, Alexandra D.T., Miller Jenkins, Lisa M., Dulcey, Andrés E., Madigan, James P., Pluchino, Kristen M., Goldsborough, Andrew S., Brimacombe, Kyle R., Griffiths, Gary L., Gottesman, Michael M.

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