Search Results - "Griffiths, Christopher E M"

Measurement, Classification and Evaluation of Sleep Disturbance in Psoriasis: A Systematic Review by Henry, Alasdair L, Kyle, Simon D, Bhandari, Sahil, Chisholm, Anna, Griffiths, Christopher E M, Bundy, Christine

“…Psoriasis is a long-term immune-mediated inflammatory disorder mainly, but not only, affecting skin, and is associated with significant medical and…”
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Comparison of Drug Discontinuation, Effectiveness, and Safety Between Clinical Trial Eligible and Ineligible Patients in BADBIR by Mason, Kayleigh J, Barker, Jonathan N W N, Smith, Catherine H, Hampton, Philip J, Lunt, Mark, McElhone, Kathleen, Warren, Richard B, Yiu, Zenas Z N, Griffiths, Christopher E M, Burden, A David

“…Patients with psoriasis enrolled in clinical trials of biologics may not be representative of the real-world population. There is evidence that patients…”
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Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis by Griffiths, Christopher E.M, Strober, Bruce E, van de Kerkhof, Peter, Ho, Vincent, Fidelus-Gort, Roseanne, Yeilding, Newman, Guzzo, Cynthia, Xia, Yichuan, Zhou, Bei, Li, Shu, Dooley, Lisa T, Goldstein, Neil H, Menter, Alan

“…In this 12-week randomized trial comparing two biologic agents known to be effective for psoriasis, ustekinumab (an interleukin-12 and interleukin-23 blocker)…”
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Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis by Andres-Ejarque, Rosa, Ale, Hira Bahadur, Grys, Katarzyna, Tosi, Isabella, Solanky, Shane, Ainali, Chrysanthi, Catak, Zeynep, Sreeneebus, Hemawtee, Saklatvala, Jake, Dand, Nick, de Rinaldis, Emanuele, Chapman, Anna, Nestle, Frank O., Barnes, Michael R., Warren, Richard B., Reynolds, Nick J., Griffiths, Christopher E. M., Barker, Jonathan N., Smith, Catherine H., Di Meglio, Paola

“…Biologic therapies have transformed the management of psoriasis, but clinical outcome is variable leaving an unmet clinical need for predictive biomarkers of…”
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Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy by Kendall, Alexandra C., Pilkington, Suzanne M., Wray, Jonathan R., Newton, Victoria L., Griffiths, Christopher E. M., Bell, Mike, Watson, Rachel E. B., Nicolaou, Anna

“…The menopause can lead to epidermal changes that are alleviated by hormone replacement therapy (HRT). We hypothesise that these changes could relate to altered…”
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Concordance and timing in recording cancer events in primary care, hospital and mortality records for patients with and without psoriasis: A population-based cohort study by Trafford, Alex M, Parisi, Rosa, Rutter, Martin K, Kontopantelis, Evangelos, Griffiths, Christopher E. M, Ashcroft, Darren M

“…Background The association between psoriasis and the risk of cancer has been investigated in numerous studies utilising electronic health records (EHRs), with…”
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Why some women look young for their age by Gunn, David A, Rexbye, Helle, Griffiths, Christopher E M, Murray, Peter G, Fereday, Amelia, Catt, Sharon D, Tomlin, Cyrena C, Strongitharm, Barbara H, Perrett, Dave I, Catt, Michael, Mayes, Andrew E, Messenger, Andrew G, Green, Martin R, van der Ouderaa, Frans, Vaupel, James W, Christensen, Kaare

“…The desire of many to look young for their age has led to the establishment of a large cosmetics industry. However, the features of appearance that primarily…”
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Psoriasis and Atopic Dermatitis by Griffiths, Christopher E. M., van de Kerkhof, Peter, Czarnecka-Operacz, Magdalena

“…Psoriasis and atopic dermatitis are common, chronic inflammatory skin diseases. We discuss several aspects of these disorders, including: risk factors;…”
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Author Correction: Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis by Andres-Ejarque, Rosa, Ale, Hira Bahadur, Grys, Katarzyna, Tosi, Isabella, Solanky, Shane, Ainali, Chrysanthi, Catak, Zeynep, Sreeneebus, Hemawtee, Saklatvala, Jake, Dand, Nick, de Rinaldis, Emanuele, Chapman, Anna, Nestle, Frank O., Barnes, Michael R., Warren, Richard B., Reynolds, Nick J., Griffiths, Christopher E. M., Barker, Jonathan N., Smith, Catherine H., Di Meglio, Paola

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Pathogenesis and clinical features of psoriasis by Griffiths, Christopher EM, Professor, Barker, Jonathan NWN, MD

“…Summary Psoriasis, a papulosquamous skin disease, was originally thought of as a disorder primarily of epidermal keratinocytes, but is now recognised as one of…”
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Psoriasis Prevalence in Adults in the United States by Armstrong, April W, Mehta, Manan D, Schupp, Clayton W, Gondo, George C, Bell, Stacie J, Griffiths, Christopher E M

“…Determining psoriasis prevalence is fundamental to understanding the burden of the disease, the populations most affected, and health policies to address the…”
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Factors Predicting Quality of Life Impairment in Adult Patients with Atopic Dermatitis: Results from a Patient Survey and Machine Learning Analysis by Paul, Carle, Griffiths, Christopher E. M., Costanzo, Antonio, Herranz, Pedro, Grond, Susanne, Mert, Can, Tietz, Nicole, Riedl, Elisabeth, Augustin, Matthias

“…Introduction Atopic dermatitis (AD) is a chronic, inflammatory skin disorder that impairs patients’ quality of life (QoL). Physician assessment of AD disease…”
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Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials by Langley, Richard G, Elewski, Boni E, Lebwohl, Mark, Reich, Kristian, Griffiths, Christopher E.M, Papp, Kim, Puig, Lluís, Nakagawa, Hidemi, Spelman, Lynda, Sigurgeirsson, Bárður, Rivas, Enrique, Tsai, Tsen-Fang, Wasel, Norman, Tyring, Stephen, Salko, Thomas, Hampele, Isabelle, Notter, Marianne, Karpov, Alexander, Helou, Silvia, Papavassilis, Charis

“…In two trials in patients with moderate-to-severe plaque psoriasis, the anti–interleukin-17A monoclonal antibody secukinumab was more effective than placebo…”
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Association of Psoriasis With the Risk of Developing or Dying of Cancer: A Systematic Review and Meta-analysis by Trafford, Alex M, Parisi, Rosa, Kontopantelis, Evangelos, Griffiths, Christopher E M, Ashcroft, Darren M

“…The risk of cancer developing in people with psoriasis has raised some concern, with little clarity regarding differentiation in risk according to psoriasis…”
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Human Mast Cells Upregulate Cathepsin B, a Novel Marker of Itch in Psoriasis by West, Peter W, Tontini, Chiara, Atmoko, Haris, Kiss, Orsolya, Garner, Terence, Bahri, Rajia, Warren, Richard B, Griffiths, Christopher E. M, Stevens, Adam, Bulfone-Paus, Silvia

“…Mast cells (MCs) contribute to skin inflammation. In psoriasis, the activation of cutaneous neuroimmune networks commonly leads to itch. To dissect the unique…”
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A randomised placebo controlled trial of anakinra for treating pustular psoriasis: statistical analysis plan for stage two of the APRICOT trial by Cro, Suzie, Patel, Prakash, Barker, Jonathan, Burden, David A, Griffiths, Christopher E M, Lachmann, Helen J, Reynolds, Nick J, Warren, Richard B, Capon, Francesca, Smith, Catherine, Cornelius, Victoria

“…Current treatment options for Palmoplantar Pustulosis (PPP), a debilitating chronic skin disease which affects the hands and feet, are limited. The Anakinra…”
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A small population, randomised, placebo-controlled trial to determine the efficacy of anakinra in the treatment of pustular psoriasis: study protocol for the APRICOT trial by Cornelius, Victoria, Wilson, Rosemary, Cro, Suzie, Barker, Jonathan, Burden, David, Griffiths, Christopher E M, Lachmann, Helen, McAteer, Helen, Reynolds, Nick, Pink, Andrew, Warren, Richard B, Capon, Francesca, Smith, Catherine

“…Palmoplantar pustulosis is a rare but painful and debilitating disease. It consistently ranks the highest of all psoriasis phenotypic variants in terms of…”
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Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene by Capon, Francesca, Bijlmakers, Marie-José, Wolf, Natalie, Quaranta, Maria, Huffmeier, Ulrike, Allen, Michael, Timms, Kirsten, Abkevich, Victor, Gutin, Alexander, Smith, Rhodri, Warren, Richard B., Young, Helen S., Worthington, Jane, Burden, A. David, Griffiths, Christopher E.M., Hayday, Adrian, Nestle, Frank O., Reis, Andre, Lanchbury, Jerry, Barker, Jonathan N., Trembath, Richard C.

“…Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage studies have clearly identified a primary disease…”
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Tumour necrosis factor alpha, interferon gamma and substance P are novel modulators of extrapituitary prolactin expression in human skin by Langan, Ewan A, Vidali, Silvia, Pigat, Natascha, Funk, Wolfgang, Lisztes, Erika, Bíró, Tamás, Goffin, Vincent, Griffiths, Christopher E M, Paus, Ralf

“…Human scalp skin and hair follicles (HFs) are extra-pituitary sources of prolactin (PRL). However, the intracutaneous regulation of PRL remains poorly…”
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Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials by Griffiths, Christopher E M, Prof, Reich, Kristian, Prof, Lebwohl, Mark, Prof, van de Kerkhof, Peter, Prof, Paul, Carle, Prof, Menter, Alan, MD, Cameron, Gregory S, PhD, Erickson, Janelle, PhD, Zhang, Lu, MS, Secrest, Roberta J, PhD, Ball, Susan, PhD, Braun, Daniel K, MD, Osuntokun, Olawale O, MD, Heffernan, Michael P, MD, Nickoloff, Brian J, MD, Papp, Kim, MD

“…Summary Background Ixekizumab is a humanised monoclonal antibody against the proinflammatory cytokine interleukin 17A. We report two studies of ixekizumab…”
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