Search Results - "Griffiths, Charmaine"

N 10 -carbonyl-substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress by Keynes, Robert G, Karchevskaya, Anastasia, Riddall, Dieter, Griffiths, Charmaine H, Bellamy, Tomas C, Chan, A W Edith, Selwood, David L, Garthwaite, John

“…During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified…”
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N10‐carbonyl‐substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress by Keynes, Robert G., Karchevskaya, Anastasia, Riddall, Dieter, Griffiths, Charmaine H., Bellamy, Tomas C., Chan, A. W. Edith, Selwood, David L., Garthwaite, John

“…During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified…”
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Differential Sensitivity of Guanylyl Cyclase and Mitochondrial Respiration to Nitric Oxide Measured Using Clamped Concentrations by Bellamy, Tomas C, Griffiths, Charmaine, Garthwaite, John

“…Nitric oxide (NO) signal transduction may involve at least two targets: the guanylyl cyclase-coupled NO receptor (NO GC R), which catalyzes cGMP formation, and…”
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The shaping of nitric oxide signals by a cellular sink by Griffiths, Charmaine, Garthwaite, John

“…The functioning of nitric oxide (NO) as a biological messenger necessitates that there be an inactivation mechanism. Cell suspensions from a rat brain region…”
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A new and simple method for delivering clamped nitric oxide concentrations in the physiological range: application to activation of guanylyl cyclase-coupled nitric oxide receptors by Griffiths, Charmaine, Wykes, Victoria, Bellamy, Tomas C, Garthwaite, John

“…The signaling molecule nitric oxide (NO) could engage multiple pathways to influence cellular function. Unraveling their relative biological importance has…”
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Superoxide-dependent consumption of nitric oxide in biological media may confound in vitro experiments by Keynes, Robert G, Griffiths, Charmaine, Garthwaite, John

“…NO functions ubiquitously as a biological messenger but has also been implicated in various pathologies, a role supported by many reports that exogenous or…”
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Nitric oxide consumption through lipid peroxidation in brain cell suspensions and homogenates by Keynes, Robert G, Griffiths, Charmaine H, Hall, Catherine, Garthwaite, John

“…Mechanisms which inactivate NO (nitric oxide) are probably important in governing the physiological and pathological effects of this ubiquitous signalling…”
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More support needed for UK charity-funded medical research by Griffiths, Charmaine, Mitchell, Michelle, Burnand, Aisling

“…Charities have been part of countless medical advances, ranging from the development of radiotherapy for cancer patients to the use of clot-busting drugs to…”
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Nitric oxide inactivation in brain by a novel O2-dependent mechanism resulting in the formation of nitrate ions by GRIFFITHS, Charmaine, YAMINI, Bakhtiar, HALL, Catherine, GARTHWAITE, John

“…In order for nitric oxide (NO) to function as a biological messenger it has to be inactivated, but little is known of how this is achieved. In cells from the…”
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Meagre spending on tobacco control is costing the economy billions

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Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase I/II clinical trial by Zhao, Tian Xiao, Kostapanos, Michalis, Griffiths, Charmaine, Arbon, Emma L, Hubsch, Annette, Kaloyirou, Fotini, Helmy, Joanna, Hoole, Stephen P, Rudd, James H F, Wood, Graham, Burling, Keith, Bond, Simon, Cheriyan, Joseph, Mallat, Ziad

“…IntroductionInflammation and dysregulated immune responses play a crucial role in atherosclerosis, underlying ischaemic heart disease (IHD) and acute coronary…”
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Nitric oxide inactivation in brain by a novel O2-dependent mechanism resulting in the formation of nitrate ions by Griffiths, Charmaine, Yamini, Bakhtiar, Hall, Catherine, Garthwaite, John

“…In order for nitric oxide (NO) to function as a biological messenger it has to be inactivated, but little is known of how this is achieved. In cells from the…”
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Dynamics of nitric oxide during simulated ischaemia-reperfusion in rat striatal slices measured using an intrinsic biosensor, soluble guanylyl cyclase by Griffiths, Charmaine, Garthwaite, Giti, Goodwin, David A., Garthwaite, John

“…Nitric oxide (NO) may act as a toxin in several neuropathologies, including the brain damage resulting from cerebral ischaemia. Rat striatal slices were used…”
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Substrate Specificity of IphP, a Cyanobacterial Dual-Specificity Protein Phosphatase with MAP Kinase Phosphatase Activity by Howell, L. Daniel, Griffiths, Charmaine, Slade, Lynelle W, Potts, Malcolm, Kennelly, Peter J

“…The substrate specificity of the cyanobacterial dual-specificity protein phosphatase, IphP, was explored using a variety of potential substrates. The enzyme…”
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Dynamics of NO-cGMP signalling in brain tissue by Griffiths, Charmaine Helen

“…Nitric oxide (NO) is established as a signalling molecule in the CNS. The kinetics of production and the mechanism of inactivation of NO have received…”
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