Search Results - "Griffin, Eadaoin W"

Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium by Kealy, John, Murray, Carol, Griffin, Eadaoin W, Lopez-Rodriguez, Ana Belen, Healy, Dáire, Tortorelli, Lucas Silva, Lowry, John P, Watne, Leiv Otto, Cunningham, Colm

“…Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and…”
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Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression by Nazmi, Arshed, Field, Robert H., Griffin, Eadaoin W., Haugh, Orla, Hennessy, Edel, Cox, Donal, Reis, Renata, Tortorelli, Lucas, Murray, Carol L., Lopez‐Rodriguez, Ana Belen, Jin, Lei, Lavelle, Ed C., Dunne, Aisling, Cunningham, Colm

“…Type I interferons (IFN‐I) are the principal antiviral molecules of the innate immune system and can be made by most cell types, including central nervous…”
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Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α by Hennessy, Edel, Griffin, Éadaoin W, Cunningham, Colm

“…Microgliosis and astrogliosis are standard pathological features of neurodegenerative disease. Microglia are primed by chronic neurodegeneration such that…”
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Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms by Skelly, Donal T., Griffin, Éadaoin W., Murray, Carol L., Harney, Sarah, O’Boyle, Conor, Hennessy, Edel, Dansereau, Marc-Andre, Nazmi, Arshed, Tortorelli, Lucas, Rawlins, J. Nicholas, Bannerman, David M., Cunningham, Colm

“…Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative cognitive dysfunction. Episodes of delirium also contribute…”
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Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males by Griffin, Éadaoin W, Mullally, Sinéad, Foley, Carole, Warmington, Stuart A, O'Mara, Shane M, Kelly, Áine M

“…Abstract Physical activity has been reported to improve cognitive function in humans and rodents, possibly via a brain-derived neurotrophic factor…”
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Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction by Griffin, Éadaoin W, Skelly, Donal T, Murray, Carol L, Cunningham, Colm

“…Systemic inflammatory events often precipitate acute cognitive dysfunction in elderly and demented populations. Delirium is a highly prevalent neuropsychiatric…”
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Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice by O'Neill, Eoin, Griffin, Éadaoin W., O'Sullivan, Ruairi, Murray, Carol, Ryan, Lucy, Yssel, Justin, Harkin, Andrew, Cunningham, Colm

“…•DSP-4 depletes hippocampal noradrenaline by > 80%.•80% noradrenergic depletion does not predispose to acute LPS-induced working memory deficits.•Noradrenaline…”
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Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus by O'Callaghan, Rachel M., Griffin, Éadaoin W., Kelly, Áine M.

“…The potential of exercise or environmental enrichment to prevent or reverse age‐related cognitive decline in rats has been widely investigated. The data…”
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Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age by McGarry, Niamh, Murray, Carol L., Garvey, Sean, Wilkinson, Abigail, Tortorelli, Lucas, Ryan, Lucy, Hayden, Lorna, Healy, Daire, Griffin, Eadaoin W., Hennessy, Edel, Arumugam, Malathy, Skelly, Donal T., Mitchell, Kevin J., Cunningham, Colm

“…•The innate immune response to poly I:C is determined by double stranded RNA length.•Blood IFN-I, induced by high MW poly I:C, is necessary for CNS…”
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Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C by Murray, Carol, Griffin, Éadaoin W, O’Loughlin, Elaine, Lyons, Aoife, Sherwin, Eoin, Ahmed, Suaad, Stevenson, Nigel J, Harkin, Andrew, Cunningham, Colm

“…Graphical abstract…”
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Exercise enhances hippocampal-dependent learning in the rat: Evidence for a BDNF-related mechanism by Griffin, Éadaoin W., Bechara, Ranya G., Birch, Amy M., Kelly, Áine M.

“…Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal‐dependent cognitive function, possibly via brain‐derived…”
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Noradrenaline acting at central β-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: Implications for neurodegeneration by McNamee, Eoin N, Ryan, Karen M, Griffin, Éadaoin W, González-Reyes, Rodrigo E, Ryan, Katie J, Harkin, Andrew, Connor, Thomas J

“…Abstract Evidence indicates that the monoamine neurotransmitter noradrenaline elicits anti-inflammatory actions in the central nervous system (CNS), and…”
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The β2 -adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity by Gleeson, Lorna C, Ryan, Katie J, Griffin, Éadaoin W, Connor, Thomas J, Harkin, Andrew

“…Abstract Excitotoxicity is a mechanism of neuronal cell death implicated in a range of neurodegenerative conditions. Systemic administration of the excitotoxin…”
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Complementary anti-inflammatory actions of the β2 -adrenoceptor agonist clenbuterol and the glucocorticoid dexamethasone in rat brain by Ryan, Katie J, Griffin, Éadaoin W, Connor, Thomas J

“…Abstract Systemic administration of the β2 -adrenoceptor agonist clenbuterol induces expression of IL-1β and its negative regulators, interleukin-1 receptor…”
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Noradrenaline acting at β-adrenoceptors induces expression of IL-1β and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex by McNamee, Eoin N., Griffin, Éadaoin W., Ryan, Karen M., Ryan, Katie J., Heffernan, Sheena, Harkin, Andrew, Connor, Thomas J.

“…Evidence indicates that noradrenaline elicits anti-inflammatory actions in the central nervous system (CNS), and plays a neuroprotective role where…”
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Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms by Skelly, Donal T., Griffin, Éadaoin W., Murray, Carol L., Harney, Sarah, O’Boyle, Conor, Hennessy, Edel, Dansereau, Marc-Andre, Nazmi, Arshed, Tortorelli, Lucas, Rawlins, J. Nicholas, Bannerman, David M., Cunningham, Colm

“…Following publication of this article, the authors noticed an error in the abstract, where they incorrectly stated that: “Direct application of IL-1β to ex…”
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Clenbuterol activates the central IL-1 system via the β2 -adrenoceptor without provoking inflammatory response related behaviours in rats by Ryan, Karen M, Griffin, Éadaoin W, Ryan, Katie J, Tanveer, Riffat, Vanattou-Saifoudine, Natacha, McNamee, Eoin N, Fallon, Emer, Heffernan, Sheena, Harkin, Andrew, Connor, Thomas J

“…Highlights • Clenbuterol induces selective expression of the IL-1 system in the CNS. • Clenbuterol does not induce a classical neuroinflammatory or sickness…”
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At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei by Reis, Renata, Hennessy, Edel, Murray, Caoimhe, Griffin, Éadaoin W., Cunningham, Colm

“…Aims The processes by which neurons degenerate in chronic neurodegenerative diseases remain unclear. Synaptic loss and axonal pathology frequently precede…”
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The β2-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1β administration to rats by Griffin, Éadaoin W., Yssel, Justin D., O'Neill, Eoin, Ryan, Katie J., Boyle, Noreen, Harper, Peter, Harkin, Andrew, Connor, Thomas

“…Objectives: Clenbuterol is a brain penetrant β 2 -adrenoceptor agonist with anti-inflammatory and putative neuroprotective properties. In the present…”
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Clenbuterol activates the central IL-1 system via the beta 2-adrenoceptor without provoking inflammatory response related behaviours in rats by Ryan, Karen M, Griffin, Eadaoin W, Ryan, Katie J, Tanveer, Riffat, Vanattou-Saifoudine, Natacha, McNamee, Eoin N, Fallon, Emer, Heffernan, Sheena, Harkin, Andrew, Connor, Thomas J

“…The long-acting, highly lipophilic, beta 2-adrenoceptor agonist clenbuterol may represent a suitable therapeutic agent for the treatment of neuroinflammation…”
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