Search Results - "Griffin, Courtney T"

Genomic locus proteomic screening identifies the NF-κB signaling pathway components NFκB1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells by Gao, Siqi, Menendez, Matthew, Kurylowicz, Katarzyna, Griffin, Courtney T.

“…The receptor-interacting protein kinase 3 (RIPK3) is a multi-functional protein best known for facilitating cellular necroptosis and inflammation. Recent…”
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Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis by Colijn, Sarah, Muthukumar, Vijay, Xie, Jun, Gao, Siqi, Griffin, Courtney T

“…Receptor-interacting protein kinase 3 (RIPK3) was recently implicated in promoting atherosclerosis progression through a proposed role in macrophage…”
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Comparative mechanistic study of RPE cell death induced by different oxidative stresses by Tong, Yao, Wu, Yinga, Ma, Jing, Ikeda, Masataka, Ide, Tomomi, Griffin, Courtney T., Ding, Xi-Qin, Wang, Shusheng

“…Oxidative stress is hypothesized to drive the progression of age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cell layer is important…”
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The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development by Xie, Jun, Gao, Siqi, Schafer, Christopher, Colijn, Sarah, Muthukumar, Vijay, Griffin, Courtney T, Schmidt, Edward E

“…ATP-dependent chromatin-remodeling complexes epigenetically modulate transcription of target genes to impact a variety of developmental processes. Our lab…”
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The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development by Griffin, Courtney T, Brennan, Jennifer, Magnuson, Terry

“…ATP-dependent chromatin-remodeling complexes contribute to the proper temporal and spatial patterns of gene expression in mammalian embryos and therefore play…”
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Selective and Marked Blockade of Endothelial Sprouting Behavior Using Paclitaxel and Related Pharmacologic Agents by Lin, Prisca K., Salvador, Jocelynda, Xie, Jun, Aguera, Kalia N., Koller, Gretchen M., Kemp, Scott S., Griffin, Courtney T., Davis, George E.

“…Whether alterations in the microtubule cytoskeleton affect the ability of endothelial cells (ECs) to sprout and form branching networks of tubes was…”
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chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels by Griffin, Courtney T, Curtis, Carol D, Davis, Reema B, Muthukumar, Vijay, Magnuson, Terry

“…The ATP-dependent chromatin-remodeling enzyme brahma-related gene 1 (BRG1) regulates transcription of specific target genes during embryonic and postnatal…”
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Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge by Schafer, Christopher M., Martin-Almedina, Silvia, Kurylowicz, Katarzyna, Dufton, Neil, Osuna-Almagro, Lourdes, Wu, Meng-Ling, Johnson, Charmain F., Shah, Aarti V., Haskard, Dorian O., Buxton, Andrianna, Willis, Erika, Wheeler, Kate, Turner, Sean, Chlebicz, Magdalena, Scott, Rizaldy P., Kovats, Susan, Cleuren, Audrey, Birdsey, Graeme M., Randi, Anna M., Griffin, Courtney T.

“…During infectious diseases, proinflammatory cytokines transiently destabilize interactions between adjacent vascular endothelial cells (ECs) to facilitate the…”
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The Chromatin-Remodeling Enzymes BRG1 and CHD4 Antagonistically Regulate Vascular Wnt Signaling by Curtis, Carol D., Griffin, Courtney T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis by Ingram, Kyle G, Curtis, Carol D, Silasi-Mansat, Robert, Lupu, Florea, Griffin, Courtney T

“…The extracellular matrix (ECM) supports vascular integrity during embryonic development. Proteolytic degradation of ECM components is required for…”
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CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity by Crosswhite, Patrick L, Podsiadlowska, Joanna J, Curtis, Carol D, Gao, Siqi, Xia, Lijun, Srinivasan, R Sathish, Griffin, Courtney T

“…The chromatin-remodeling enzyme CHD4 maintains vascular integrity at mid-gestation; however, it is unknown whether this enzyme contributes to later blood…”
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Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development by de Castro, Rodrigo O, Carbajal, Agustin, Previato de Almeida, Luciana, Goitea, Victor, Griffin, Courtney T, Pezza, Roberto J

“…Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper…”
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Deficient RPE mitochondrial energetics leads to subretinal fibrosis in age-related neovascular macular degeneration by Ma, Xiang, Wu, Wenjing, Hara, Miwa, Zhou, Junwen, Panzarin, Carolina, Schafer, Christopher M., Griffin, Courtney T., Cai, Jiyang, Ma, Jian-Xing, Takahashi, Yusuke

“…Subretinal fibrosis permanently impairs the vision of patients with neovascular age-related macular degeneration. Despite emerging evidence revealing the…”
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SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice by Wiley, Mandi M, Muthukumar, Vijay, Griffin, Timothy M, Griffin, Courtney T

“…Mammalian SWItch/Sucrose NonFermentable (SWI/SNF) adenosine triphosphate (ATP)-dependent chromatin-remodeling complexes play important roles in embryonic…”
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Proinflammatory mediators, TNFα, IFNγ, and thrombin, directly induce lymphatic capillary tube regression by Kemp, Scott S, Penn, Marlena R, Koller, Gretchen M, Griffin, Courtney T, Davis, George E

“…In this work, we sought to investigate the direct effects of proinflammatory mediators on lymphatic endothelial cell (LEC) capillaries and whether they might…”
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An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins by Gullapalli, Anuradha, Wolfe, Breann L, Griffin, Courtney T, Magnuson, Terry, Trejo, JoAnn

“…Sorting nexin 1 (SNX1) and SNX2 are the mammalian homologues of the yeast Vps5p retromer component that functions in endosome-to-Golgi trafficking. SNX1 is…”
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Genetic Evidence for a Mammalian Retromer Complex Containing Sorting Nexins 1 and 2 by Griffin, Courtney T., Trejo, JoAnn, Magnuson, Terry

“…We have previously shown that the putative mammalian retromer components sorting nexins 1 and 2 (Snx1 and Snx2) result in embryonic lethality when…”
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The Role of Endothelial PARs in Modulating Insulin Signaling by Rajala, Rahul, Griffin, Courtney T.

“…Endothelial cell (EC) dysfunction occurs in diabetes. Thrombin, a circulating serine protease with increased activity in diabetics, signals through the…”
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Endothelial dysfunction and angiogenesis impairment in the ageing vasculature by Ungvari, Zoltan, Tarantini, Stefano, Kiss, Tamas, Wren, Jonathan D., Giles, Cory B., Griffin, Courtney T., Murfee, Walter Lee, Pacher, Pal, Csiszar, Anna

“…Ageing is the main risk factor for the development of cardiovascular diseases. A central mechanism by which ageing promotes vascular pathologies is…”
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Chromatin-remodeling complex specificity and embryonic vascular development by Curtis, Carol D., Davis, Reema B., Ingram, Kyle G., Griffin, Courtney T.

“…Vascular development is a dynamic process that relies on the coordinated expression of numerous genes, but the factors that regulate gene expression during…”
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