Search Results - "Grieve, Adam"

Extracellular cleavage of E-cadherin promotes epithelial cell extrusion by Grieve, Adam G, Rabouille, Catherine

“…Epithelial cell extrusion and subsequent apoptosis is a key mechanism to prevent the accumulation of excess cells. By contrast, when driven by oncogene…”
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The multiple facets of the Golgi reassembly stacking proteins by Vinke, Fabian P, Grieve, Adam G, Rabouille, Catherine

“…The mammalian GRASPs (Golgi reassembly stacking proteins) GRASP65 and GRASP55 were first discovered more than a decade ago as factors involved in the stacking…”
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Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling by Grieve, Adam Graham, Xu, Hongmei, Künzel, Ulrike, Bambrough, Paul, Sieber, Boris, Freeman, Matthew

“…Proteolytic cleavage and release from the cell surface of membrane-tethered ligands is an important mechanism of regulating intercellular signalling. TACE is a…”
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iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells by Sieber, Boris, Lu, Fangfang, Stribbling, Stephen M, Grieve, Adam G, Ryan, Anderson J, Freeman, Matthew

“…Dysregulation of the ERBB/EGFR signalling pathway causes multiple types of cancer. Accordingly, ADAM17, the primary shedding enzyme that releases and activates…”
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Golgi bypass: skirting around the heart of classical secretion by Grieve, Adam G, Rabouille, Catherine

“…Classical secretion consists of the delivery of transmembrane and soluble proteins to the plasma membrane and the extracellular medium, respectively, and is…”
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FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex by Künzel, Ulrike, Grieve, Adam Graham, Meng, Yao, Sieber, Boris, Cowley, Sally A, Freeman, Matthew

“…Many intercellular signals are synthesised as transmembrane precursors that are released by proteolytic cleavage ('shedding') from the cell surface. ADAM17, a…”
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Substrates and physiological functions of secretase rhomboid proteases by Lastun, Viorica L., Grieve, Adam G., Freeman, Matthew

“…Rhomboids are conserved intramembrane serine proteases with widespread functions. They were the earliest discovered members of the wider rhomboid-like…”
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Bacterial rhomboid proteases mediate quality control of orphan membrane proteins by Liu, Guangyu, Beaton, Stephen E, Grieve, Adam G, Evans, Rhiannon, Rogers, Miranda, Strisovsky, Kvido, Armstrong, Fraser A, Freeman, Matthew, Exley, Rachel M, Tang, Christoph M

“…Although multiprotein membrane complexes play crucial roles in bacterial physiology and virulence, the mechanisms governing their quality control remain…”
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Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation by Grieve, Adam G., Yeh, Yi-Chun, Chang, Yu-Fen, Huang, Hsin-Yi, Zarcone, Lucrezia, Breuning, Johannes, Johnson, Nicholas, Stříšovský, Kvido, Brown, Marion H., Parekh, Anant B., Freeman, Matthew

“…Calcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many…”
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Annexin A2 at the Interface of Actin and Membrane Dynamics: A Focus on Its Roles in Endocytosis and Cell Polarization by Grieve, Adam G., Moss, Stephen E., Hayes, Matthew J.

“…Annexins are a family of calcium- and phospholipid-binding proteins found in nearly all eukaryotes. They are structurally highly conserved and have been…”
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The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions by Dorland, Yvonne L., Malinova, Tsveta S., van Stalborch, Anne-Marieke D., Grieve, Adam G., van Geemen, Daphne, Jansen, Nicolette S., de Kreuk, Bart-Jan, Nawaz, Kalim, Kole, Jeroen, Geerts, Dirk, Musters, René J. P., de Rooij, Johan, Hordijk, Peter L., Huveneers, Stephan

“…Vascular homoeostasis, development and disease critically depend on the regulation of endothelial cell–cell junctions. Here we uncover a new role for the F-BAR…”
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Test Review: Bayley, N. (2006). Bayley Scales of Infant and Toddler Development– Third Edition. San Antonio, TX: Harcourt Assessment by Albers, Craig A., Grieve, Adam J.

“…The Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III) is a revision of the frequently used and well-known Bayley Scales of Infant…”
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Neurocognitive function and state cognitive stress appraisal predict cortisol reactivity to an acute psychosocial stressor in adolescents by Slattery, Marcia J, Grieve, Adam J, Ames, Michelle E, Armstrong, Jeffrey M, Essex, Marilyn J

“…Summary Stress and associated alterations in hypothalamic–pituitary–adrenal (HPA) function have deleterious influence on the development of multiple mental and…”
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Golgi Bypass: Skirting Around the Heart of Classical Secretion by Grieve, A. G., Rabouille, C.

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GRASP65 controls the cis Golgi integrity in vivo by Veenendaal, Tineke, Jarvela, Tim, Grieve, Adam G, van Es, Johan H, Linstedt, Adam D, Rabouille, Catherine

“…GRASP65 and GRASP55 are peripheral Golgi proteins localized to cis and medial/trans cisternae, respectively. They are implicated in diverse aspects of protein…”
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Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice by Siggs, Owen M, Grieve, Adam, Xu, Hongmei, Bambrough, Paul, Christova, Yonka, Freeman, Matthew

“…iRhoms are closely related to rhomboid intramembrane proteases but lack catalytic activity. In mammals iRhoms are known to regulate the trafficking of TACE,…”
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Associations Between Academic Achievement and Psychosocial Variables in Adolescents With Cystic Fibrosis by Grieve, Adam J., Tluczek, Audrey, Racine-Gilles, Caroline N., Laxova, Anita, Albers, Craig A., Farrell, Philip M.

“…BACKGROUND: Cystic fibrosis (CF) is a chronic genetic disease that leads to the accumulation of thick mucus in multiple organ systems, leading to chronic lung…”
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Relationships Among Health-Related Quality of Life, Pulmonary Health, and Newborn Screening for Cystic Fibrosis by Tluczek, Audrey, PhD, RN, Becker, Tara, PhD, Laxova, Anita, BS, Grieve, Adam, MS, Gilles, Caroline N. Racine, PhD, Rock, Michael J., MD, Gershan, William M., MD, FCCP, Green, Christopher G., MD, Farrell, Philip M., MD, PhD

“…Background The objective of this study was to examine relationships between pulmonary health and health-related quality of life (HRQOL) in patients with cystic…”
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Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells by Grieve, Adam G, Daniels, Rachel D, Sanchez-Heras, Elena, Hayes, Matthew J, Moss, Stephen E, Matter, Karl, Lowe, Martin, Levine, Timothy P

“…Mutations in the inositol polyphosphate 5-phosphatase OCRL1 cause Lowe Syndrome, leading to cataracts, mental retardation and renal failure. We noted that cell…”
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Rhomboid Proteins in Cell Signaling by Freeman, Matthew, Grieve, Adam

“…Cellular membranes are important biological interfaces. Not only do they compartmentalise cells from the environment and organelles from each other, but they…”
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