Search Results - "Grierson, David"

The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets by Legraverend, Michel, Grierson, David S.

“…Different combinations of substituents R 1–R 7 on the purine ring lead to compounds displaying potent and selective activity against a wide range of protein…”
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Wear Performance of incoloy 800HT and inconel 617 in various surface conditions for high-temperature gas-cooled reactor components by Pauly, Valentin, Kern, Joseph, Clark, Malcolm, Grierson, David S., Sridharan, Kumar

“…Incoloy™ 800HT and Inconel™ 617 are primary candidate structural materials for high-temperature gas-cooled reactors (HTGRs). Impurities (e.g., H2O, CH4) in the…”
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Reaction of 3‑Cl/OMe-Substituted 5‑Nitrobenzisothiazoles with Hydrazine: Structural and Computational Evidence for Rearrangement Pathways Implicating Intramolecular Formation of Pivotal Meisenheimer Complexes by Lin, Zheng Sonia, Tong, Xing, Patrick, Brian, Kennepohl, Pierre, Grierson, David S

“…In projected structure–activity relationship studies of the novel diheteroarylamide-based anti-HIV agent 2 (1C8), one objective was to evaluate the influence…”
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Adhesion of nanoscale asperities with power-law profiles by Grierson, David S., Liu, Jingjing, Carpick, Robert W., Turner, Kevin T.

“…The behavior of single-asperity micro- and nanoscale contacts in which adhesion is present is important for the performance of many small-scale mechanical…”
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Tribochemical Wear of Diamond-Like Carbon-Coated Atomic Force Microscope Tips by Liu, Jingjing, Jiang, Yijie, Grierson, David S., Sridharan, Kumar, Shao, Yuchong, Jacobs, Tevis D. B., Falk, Michael L., Carpick, Robert W., Turner, Kevin T.

“…Nanoscale wear is a critical issue that limits the performance of tip-based nanomanufacturing and nanometrology processes based on atomic force microscopy…”
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Stereoselective Direct Copper-Catalyzed Alkenylation of Oxazoles with Bromoalkenes by Besselièvre, François, Piguel, Sandrine, Mahuteau-Betzer, Florence, Grierson, David S

“…A copper-catalyzed direct alkenylation of oxazoles with bromoalkenes has been developed. The method is both regio- and stereoselective and tolerates a variety…”
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Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication by Shkreta, Lulzim, Blanchette, Marco, Toutant, Johanne, Wilhelm, Emmanuelle, Bell, Brendan, Story, Benjamin A, Balachandran, Ahalya, Cochrane, Alan, Cheung, Peter K, Harrigan, P Richard, Grierson, David S, Chabot, Benoit

“…We recently identified the 4-pyridinone-benzisothiazole carboxamide compound 1C8 as displaying strong anti-HIV-1 potency against a variety of clinical strains…”
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Mechanics of Interaction and Atomic-Scale Wear of Amplitude Modulation Atomic Force Microscopy Probes by Vahdat, Vahid, Grierson, David S, Turner, Kevin T, Carpick, Robert W

“…Wear is one of the main factors that hinders the performance of probes for atomic force microscopy (AFM), including for the widely used amplitude modulation…”
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The Effect of Atomic-Scale Roughness on the Adhesion of Nanoscale Asperities: A Combined Simulation and Experimental Investigation by Jacobs, Tevis D. B., Ryan, Kathleen E., Keating, Pamela L., Grierson, David S., Lefever, Joel A., Turner, Kevin T., Harrison, Judith A., Carpick, Robert W.

“…The effect of atomic-scale roughness on adhesion between carbon-based materials is examined by both simulations and experimental techniques. Nanoscale…”
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Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production by Chabrolles, Hélène, Auclair, Héloïse, Vegna, Serena, Lahlali, Thomas, Pons, Caroline, Michelet, Maud, Couté, Yohann, Belmudes, Lucid, Chadeuf, Gilliane, Kim, Yujin, Di Bernardo, Ariel, Jalaguier, Pascal, Cosset, François-Loïc, Fusil, Floriane, Rivoire, Michel, Arnold, Lee D, Lopatin, Uri, Combet, Christophe, Zoulim, Fabien, Grierson, David, Chabot, Benoit, Lucifora, Julie, Durantel, David, Salvetti, Anna

“…Despite the existence of a preventive vaccine, chronic infection with Hepatitis B virus (HBV) affects more than 250 million people and represents a major…”
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Ligandless Microwave-Assisted Pd/Cu-Catalyzed Direct Arylation of Oxazoles by Besselièvre, François, Mahuteau-Betzer, Florence, Grierson, David S., Piguel, Sandrine

“…An efficient microwave-assisted palladium/copper co-mediated direct arylation of oxazoles with aryl bromides under ligandless conditions has been developed…”
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Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth by PRUDENT, Renaud, VASSAL-STERMANN, Emilie, VALDAMERI, Glaucio, HONORE, Stéphane, ACI-SECHE, Samia, GRIERSON, David, ANTONIPILLAI, Juliana, RONG LI, DI PIETRO, Attilio, DUMONTET, Charles, BRAGUER, Diane, FLORENT, Jean-Claude, NGUYEN, Chi-Hung, KNAPP, Stefan, BERNARD, Ora, LAFANECHERE, Laurence, PILLET, Catherine, MARTINEZ, Anne, PRUNIER, Chloe, BARETTE, Caroline, SOLEILHAC, Emmanuelle, FILHOL, Odile, BEGHIN, Anne

“…The emergence of tumor resistance to conventional microtubule-targeting drugs restricts their clinical use. Using a cell-based assay that recognizes…”
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Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies by Durand, Sébastien, Cougot, Nicolas, Mahuteau-Betzer, Florence, Nguyen, Chi-Hung, Grierson, David S, Bertrand, Edouard, Tazi, Jamal, Lejeune, Fabrice

“…In mammals, nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that degrades mRNA harboring a premature termination codon to prevent the…”
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2‑Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing by Zamiri, Maryam, Cheung, Peter K, Brockman, Mark A, Brumme, Zabrina L, Chabot, Benoit, Cochrane, Alan, Grierson, David S

“…The observation that stilbene 3 (5350150) blocks HIV replication through its impact on HIV mRNA processing prompted a program to develop non-cytotoxic…”
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Development of Novel Monoamine Oxidase‑B (MAO-B) Inhibitors with Reduced Blood–Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases by Gealageas, Ronan, Devineau, Alice, So, Pauline P. L., Kim, Catrina M. J., Surendradoss, Jayakumar, Buchwalder, Christian, Heller, Markus, Goebeler, Verena, Dullaghan, Edith M., Grierson, David S., Putnins, Edward E.

“…Studies indicate that MAO-B is induced in peripheral inflammatory diseases. To target peripheral tissues using MAO-B inhibitors that do not permeate the…”
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A Parallel Synthesis Approach to the Identification of Novel Diheteroarylamide-Based Compounds Blocking HIV Replication: Potential Inhibitors of HIV‑1 Pre-mRNA Alternative Splicing by Cheung, Peter K, Horhant, David, Bandy, Laura E, Zamiri, Maryam, Rabea, Safwat M, Karagiosov, Stoyan K, Matloobi, Mitra, McArthur, Steven, Harrigan, P. Richard, Chabot, Benoit, Grierson, David S

“…A 256-compound library was evaluated in an anti-HIV screen to identify structural “mimics” of the fused tetracyclic indole compound 1 (IDC16) that conserve its…”
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The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation by Dahal, Subha, Cheng, Ran, Cheung, Peter K, Been, Terek, Malty, Ramy, Geng, Melissa, Manianis, Sarah, Shkreta, Lulzim, Jahanshahi, Shahrazad, Toutant, Johanne, Chan, Rose, Park, Sean, Brockman, Mark A, Babu, Mohan, Mubareka, Samira, Mossman, Karen, Banerjee, Arinjay, Gray-Owen, Scott, Brown, Martha, Houry, Walid A, Chabot, Benoit, Grierson, David, Cochrane, Alan

“…Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the…”
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New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights by López-Ramos, Miriam, Prudent, Renaud, Moucadel, Virginie, Sautel, Céline F, Barette, Caroline, Lafanechère, Laurence, Mouawad, Liliane, Grierson, David, Schmidt, Frédéric, Florent, Jean-Claude, Filippakopoulos, Panagis, Bullock, Alex N, Knapp, Stefan, Reiser, Jean-Baptiste, Cochet, Claude

“…Protein kinase casein kinase 2 (CK2) is a serine/threonine kinase with evidence of implication in growth dysregulation and apoptosis resistance, making it a…”
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Simulated Adhesion between Realistic Hydrocarbon Materials: Effects of Composition, Roughness, and Contact Point by Ryan, Kathleen E, Keating, Pamela L, Jacobs, Tevis D. B, Grierson, David S, Turner, Kevin T, Carpick, Robert W, Harrison, Judith A

“…The work of adhesion is an interfacial materials property that is often extracted from atomic force microscope (AFM) measurements of the pull-off force for…”
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2‑Aminothiazole-4-carboxamides Enhance Readthrough of Premature Termination Codons by Aminoglycosides by Rabea, Safwat M, Baradaran-Heravi, Alireza, Balgi, Aruna D, Krause, Alexandra, Hosseini Farahabadi, Sara, Roberge, Michel, Grierson, David S

“…Nonsense mutations introduce a premature termination codon (PTC) and are the underlying cause of multiple rare genetic diseases and cancers. Although certain…”
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