Search Results - "Gribnau, J."

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells by Gunhanlar, N, Shpak, G, van der Kroeg, M, Gouty-Colomer, L A, Munshi, S T, Lendemeijer, B, Ghazvini, M, Dupont, C, Hoogendijk, W J G, Gribnau, J, de Vrij, F M S, Kushner, S A

“…Progress in elucidating the molecular and cellular pathophysiology of neuropsychiatric disorders has been hindered by the limited availability of living human…”
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Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells by Mira-Bontenbal, H., Tan, B., Gontan, C., Goossens, S., Boers, R.G., Boers, J.B., Dupont, C., van Royen, M.E., IJcken, W.F.J., French, P., Bedalov, A., Gribnau, J.

“…Rett syndrome may be treated by reactivating the silent copy of Mecp2 from the inactive X chromosome in female cells. Most studies that model Mecp2…”
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X chromosome inactivation in a female carrier of a 1.28 Mb deletion encompassing the human X inactivation centre by de Hoon, B., Splinter, Erik, Eussen, B., Douben, J. C. W., Rentmeester, E., van de Heijning, M., Laven, J. S. E., de Klein, J. E. M. M., Liebelt, J., Gribnau, J.

“…X chromosome inactivation (XCI) is a mechanism specifically initiated in female cells to silence one X chromosome, thereby equalizing the dose of X-linked gene…”
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Topical haemostatic agents for skin wounds: a systematic review by Groenewold, Marieke D, Gribnau, Astrid J, Ubbink, Dirk T

“…Various agents and techniques have been introduced to limit intra-operative blood loss from skin lesions. No uniformity regarding the type of haemostasis…”
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U-shaped sacral fractures: Surgical treatment and quality of life by Gribnau, A.J.G, Hensbroek, P. Boele van, Haverlag, R, Ponsen, K.J, Been, H.D, Goslings, J.C

“…Abstract Background U-shaped sacral fractures are rare and highly unstable pelvic ring fractures. They are not recognised in the standard classification…”
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The role of EKLF in human beta-globin gene competition by Wijgerde, M, Gribnau, J, Trimborn, T, Nuez, B, Philipsen, S, Grosveld, F, Fraser, P

“…We have investigated the role of erythroid Kruppel-like factor (EKLF) in expression of the human beta-globin genes in compound EKLF knockout/human beta-locus…”
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Choice of Comparator in Active Control Trials of New Drugs by van Luijn, Johan CF, van Loenen, Arie C, Gribnau, Frank WJ, Leufkens, Hubert GM

“…Background: When choosing the active control group in a randomized that, it is important to maintain standard treatment for the therapeutic indication for…”
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Superior efficacy of new medicines? by van Luijn, Johan C. F., Gribnau, Frank W. J., Leufkens, Hubert G. M.

“…Purpose To provide an overview of and discuss newly authorised medicines with an improved efficacy. Methods This analysis focussed on new medicines with an…”
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Availability of comparative trials for the assessment of new medicines in the European Union at the moment of market authorization by Van Luijn, Johan C. F., Gribnau, Frank W. J., Leufkens, Hubert G. M.

“…What is already known about this subject • The assessment of the added therapeutic value of new medicines with a new active substance is hampered by the lack…”
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Post-approval trials of new medicines: widening use or deepening knowledge? Analysis of 10 years of etanercept by van Luijn, JCF, Danz, M, Bijlsma, JWJ, Gribnau, FWJ, Leufkens, HGM

“…Objective: To investigate the main aims of the post-approval randomized controlled trials (RCTs) on etanercept and the extent to which they were designed to…”
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Derivation of embryonic germ cells and male gametes from embryonic stem cells by Daley, George Q, Geijsen, Niels, Horoschak, Melissa, Kim, Kitai, Gribnau, Joost, Eggan, Kevin

“…Egg and sperm cells (gametes) of the mouse are derived from a founder population of primordial germ cells that are set aside early in embryogenesis. Primordial…”
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MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma by Vos, M., Boers, R., Vriends, A.L.M., Boers, J., van Kuijk, P.F., Van Houdt, W., van Leenders, G J L H, Wagrodzki, M., van IJcken, W.F.J., Gribnau, J., Grünhagen, D.J., Verhoef, C., Sleijfer, S., Wiemer, E.A.C.

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1723P - MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma by Vos, M., Boers, R., Vriends, A.L.M., Boers, J., van Kuijk, P.F., Van Houdt, W., van Leenders, G J L H, Wagrodzki, M., van IJcken, W.F.J., Gribnau, J., Grünhagen, D.J., Verhoef, C., Sleijfer, S., Wiemer, E.A.C.

“…Approximately one-third of the patients with well-differentiated liposarcoma (WDLPS) will develop a local recurrence after resection of the primary tumor. Not…”
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X Inactivation Counting and Choice Is a Stochastic Process: Evidence for Involvement of an X-Linked Activator by Monkhorst, Kim, Jonkers, Iris, Rentmeester, Eveline, Grosveld, Frank, Gribnau, Joost

“…Female mammalian cells achieve dosage compensation of X-encoded genes by X chromosome inactivation (XCI). This process is thought to involve X chromosome…”
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Monitoring and maintaining the differentiation status of human ipsc derived kidney organoids by Du, Z.S., Shankar, A.S., Korevaar, S., van den Bosch, T., Clahsen-van Groningen, M., Gribnau, J., Hoorn, E., Baan, C., Hoogduijn, M.J.

“…Human induced pluripotent stem cell (iPSC) derived kidney organoids resemble first trimester fetal kidney and offer a great model for studying kidney…”
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Gap in publication of comparative information on new medicines by Van Luijn, Johan C. F., Stolk, Pieter, Gribnau, Frank W. J., Leufkens, Hubert G. M.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Randomized active control trials are used by health care professionals and reimbursement authorities for the…”
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Assessment of outcome in ankylosing spondylitis: an extended radiographic scoring system by Creemers, M C W, Franssen, M J A M, van ’t Hof, M A, Gribnau, F W J, van de Putte, L B A, van Riel, P L C M

“…Objective: To develop and validate an extensive radiographic scoring system for ankylosing spondylitis (AS). Methods: The Stoke Ankylosing Spondylitis Spinal…”
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1723PMicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma by Vos, M, Boers, R, Vriends, A L M, Boers, J, van Kuijk, P F, Van Houdt, W, van Leenders, G J L H, Wagrodzki, M, van IJcken, W F J, Gribnau, J, Grünhagen, D J, Verhoef, C, Sleijfer, S, Wiemer, E A C

“…Abstract Background Approximately one-third of the patients with well-differentiated liposarcoma (WDLPS) will develop a local recurrence after resection of the…”
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Human kidney organoids produce functional renin by Shankar, A.S., Du, Z.S., Mora, H. Tejeda, van den Bosch, T., Korevaar, S., van den Berg-Garrelds, I., Bindels, E., Iglesias, C. Lopez, Clahsen - van Groningen, M., Gribnau, J., Baan, C., Danser, J., Hoorn, E., Hoogduijn, M.J.

“…Renin production by the kidney dictates salt, volume, and blood pressure homeostasis. There is a worldwide increase in end stage kidney disease patients that…”
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The dynamics of globin gene expression and gene therapy vectors by Grosveld, F, de Boer, E, Dillon, N, Fraser, P, Gribnau, J, Milot, E, Trimborn, T, Wijgerde, M

“…The most important level of the regulation of the beta-globin genes is by activation of all of the genes by the locus control region (LCR). Part of the…”
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