Search Results - "Grible, Jacqueline M"

Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer by Byers, Holly A., Brooks, Amy N., Vangala, Janakiram R., Grible, Jacqueline M., Feygin, Alex, Clevenger, Charles V., Harrell, J. Chuck, Radhakrishnan, Senthil K.

“…Proteasomes are multi-subunit complexes that specialize in protein degradation. Cancer cells exhibit a heightened dependence on proteasome activity, presumably…”
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Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer by Woock, Alicia E., Grible, Jacqueline M., Olex, Amy L., Harrell, J. Chuck, Zot, Patricija, Idowu, Michael, Clevenger, Charles V.

“…In breast cancer, prolactin-induced activation of the transcription factor STAT5a results from the phosphorylation of STAT5a tyrosine residue 694. However, its…”
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Rewiring of the 3D genome during acquisition of carboplatin resistance in a triple-negative breast cancer patient-derived xenograft by Dozmorov, Mikhail G., Marshall, Maggie A., Rashid, Narmeen S., Grible, Jacqueline M., Valentine, Aaron, Olex, Amy L., Murthy, Kavita, Chakraborty, Abhijit, Reyna, Joaquin, Figueroa, Daniela Salgado, Hinojosa-Gonzalez, Laura, Da-Inn Lee, Erika, Baur, Brittany A., Roy, Sushmita, Ay, Ferhat, Harrell, J. Chuck

“…Changes in the three-dimensional (3D) structure of the genome are an emerging hallmark of cancer. Cancer-associated copy number variants and single nucleotide…”
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Publisher Correction: Rewiring of the 3D genome during acquisition of carboplatin resistance in a triple-negative breast cancer patient-derived xenograft by Dozmorov, Mikhail G., Marshall, Maggie A., Rashid, Narmeen S., Grible, Jacqueline M., Valentine, Aaron, Olex, Amy L., Murthy, Kavita, Chakraborty, Abhijit, Reyna, Joaquin, Figueroa, Daniela Salgado, Hinojosa-Gonzalez, Laura, Da-Inn Lee, Erika, Baur, Brittany A., Roy, Sushmita, Ay, Ferhat, Harrell, J. Chuck

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Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer by Rashid, Narmeen S., Boyd, David C., Olex, Amy L., Grible, Jacqueline M., Duong, Alex K., Alzubi, Mohammad A., Altman, Julia E., Leftwich, Tess J., Valentine, Aaron D., Hairr, Nicole S., Zboril, Emily K., Smith, Timothy M., Pfefferle, Adam D., Dozmorov, Mikhail G., Harrell, J. Chuck

“…The goals of this study were to identify transcriptomic changes that arise in basal-like breast cancer cells during the development of resistance to epidermal…”
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Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer by Rashid, Narmeen S., Hairr, Nicole S., Murray, Graeme, Olex, Amy L., Leftwich, Tess J., Grible, Jacqueline M., Reed, Jason, Dozmorov, Mikhail G., Harrell, J. Chuck

“…•High-throughput drug screening reveals promising therapeutic candidates for TNBC.•KPT-330, an XPO1 inhibitor, and GSK2126458 exhibit synergism in preclinical…”
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The human intermediate prolactin receptor is a mammary proto-oncogene by Grible, Jacqueline M., Zot, Patricija, Olex, Amy L., Hedrick, Shannon E., Harrell, J. Chuck, Woock, Alicia E., Idowu, Michael O., Clevenger, Charles V.

“…The hormone prolactin (PRL) and its receptor (hPRLr) are significantly involved in breast cancer pathogenesis. The intermediate hPRLr (hPRLrI) is an…”
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Breast cancer liver metastasis: current and future treatment approaches by Rashid, Narmeen S., Grible, Jacqueline M., Clevenger, Charles V., Harrell, J. Chuck

“…Nearly all fatalities arising from breast tumors are attributable to distant metastases. Breast cancer liver metastasis (BCLM) is associated with poor…”
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Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs by Boyd, David C, Zboril, Emily K, Olex, Amy L, Leftwich, Tess J, Hairr, Nicole S, Byers, Holly A, Valentine, Aaron D, Altman, Julia E, Alzubi, Mohammad A, Grible, Jacqueline M, Turner, Scott A, Ferreira-Gonzalez, Andrea, Dozmorov, Mikhail G, Harrell, J Chuck

“…Basal-like triple-negative breast cancer (TNBC) tumor cells are difficult to eliminate due to resistance mechanisms that promote survival. While this breast…”
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Stratification of Tamoxifen Synergistic Combinations for the Treatment of ER+ Breast Cancer by Zboril, Emily K, Grible, Jacqueline M, Boyd, David C, Hairr, Nicole S, Leftwich, Tess J, Esquivel, Madelyn F, Duong, Alex K, Turner, Scott A, Ferreira-Gonzalez, Andrea, Olex, Amy L, Sartorius, Carol A, Dozmorov, Mikhail G, Harrell, J Chuck

“…Breast cancer alone accounts for the majority of cancer deaths among women, with the most commonly diagnosed subtype being estrogen receptor positive (ER+)…”
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Abstract 870: The role of the intermediate prolactin receptor in breast cancer oncogenesis by Grible, Jacqueline M., Clevenger, Charles V.

“…Abstract Epidemiological, cellular, and genetic analyses indicate the hormone prolactin (PRL) and its cognate receptor in humans (hPRLr) are significantly…”
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Abstract P4-08-02: The human intermediate prolactin receptor is a breast cancer oncogene by Grible, Jacqueline M, Hedrick, Shannon E, Clevenger, Charles V

“…Abstract Epidemiological, cellular, and genetic analyses indicate the hormone prolactin (PRL) and its cognate receptor in humans (hPRLr) are significantly…”
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Abstract P3-09-06: Targeting tumor subpopulations based on single-cell transcriptomics by Grible, Jacqueline M, Leftwich, Tess, Olex, Amy L, Duong, Alex K, Hairr, Nicole, Rashid, Narmeen S, Smith, Timothy M, Signaevskaia, Lia, Boyd, David C, Dozmorov, Mikhail G, Harrell, Joshua C

“…Abstract Breast cancers that are hormone receptor negative, such that they do not express the estrogen receptor (ER), progesterone receptor (PR), or human…”
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SAT-130 The Intermediate Prolactin Receptor Is a Breast Cancer Oncogene by Grible, Jacqueline M, Zot, Patricija, Harrell, J Chuck, Idowu, Michael, Clevenger, Charles V

“…Abstract Epidemiological, cellular, and genetic analyses indicate the hormone prolactin (PRL) and its cognate receptor in humans (hPRLr) are significantly…”
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SAT-139 STAT5A Regulation by Serine Phosphorylation in Breast Cancer by Woock, Alicia E, Grible, Jacqueline M, Zot, Patricija, Harrell, J Chuck, Michael, Idowu, Clevenger, Charles V

“…Abstract The neuroendocrine hormone prolactin (PRL) and its cognate receptor (PRLr) have been implicated in the pathogenesis of breast cancer. PRL signaling…”
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