Search Results - "Gribble, F M"

SCFAs strongly stimulate PYY production in human enteroendocrine cells by Larraufie, P., Martin-Gallausiaux, C., Lapaque, N., Dore, J., Gribble, F. M., Reimann, F., Blottiere, H. M.

“…Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational…”
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Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion by Parker, H. E., Adriaenssens, A., Rogers, G., Richards, P., Koepsell, H., Reimann, F., Gribble, F. M.

“…Aims/hypothesis Several glucose-sensing pathways have been implicated in glucose-triggered secretion of glucagon-like peptide-1 (GLP-1) from intestinal L…”
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Molecular mechanisms underlying bile acid‐stimulated glucagon‐like peptide‐1 secretion by Parker, HE, Wallis, K, le Roux, CW, Wong, KY, Reimann, F, Gribble, FM

“…BACKGROUND AND PURPOSE The glucagon‐like peptides GLP‐1 and GLP‐2 are secreted from enteroendocrine L‐cells following nutrient ingestion. Drugs that increase…”
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Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells by Habib, A. M., Richards, P., Rogers, G. J., Reimann, F., Gribble, F. M.

“…Aims/hypothesis Targeting the secretion of gut peptides such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) is a strategy under development for the…”
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Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells by Parker, H. E, Habib, A. M, Rogers, G. J, Gribble, F. M, Reimann, F

“…Aims/hypothesis Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with anti-apoptotic effects on the pancreatic beta cell. The aim of…”
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Sulphonylurea action revisited: the post-cloning era by GRIBBLE, F. M, REIMANN, F

“…Hypoglycaemic agents such as sulphonylureas and the newer group of "glinides" stimulate insulin secretion by closing ATP-sensitive potassium (K(ATP)) channels…”
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GDF15 linked to maternal risk of nausea and vomiting during pregnancy by Fejzo, M., Rocha, N., Cimino, I., Lockhart, S. M., Petry, C. J., Kay, R. G., Burling, K., Barker, P., George, A. L., Yasara, N., Premawardhena, A., Gong, S., Cook, E., Rimmington, D., Rainbow, K., Withers, D. J., Cortessis, V., Mullin, P. M., MacGibbon, K. W., Jin, E., Kam, A., Campbell, A., Polasek, O., Tzoneva, G., Gribble, F. M., Yeo, G. S. H., Lam, B. Y. H., Saudek, V., Hughes, I. A., Ong, K. K., Perry, J. R. B., Sutton Cole, A., Baumgarten, M., Welsh, P., Sattar, N., Smith, G. C. S., Charnock-Jones, D. S., Coll, A. P., Meek, C. L., Mettananda, S., Hayward, C., Mancuso, N., O’Rahilly, S.

“…GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum…”
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Preproglucagon neurons project widely to autonomic control areas in the mouse brain by Llewellyn-Smith, I.J, Reimann, F, Gribble, F.M, Trapp, S

“…Abstract Glucagon-like peptide 1 (GLP-1) and its analogue exendin-4 inhibit food intake, reduce blood glucose levels and increase blood pressure and heart rate…”
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Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4 by Casas, S, Novials, A, Reimann, F, Gomis, R, Gribble, F. M

“…Aims/hypothesis To investigate the mechanism by which human islet amyloid polypeptide (hIAPP) fibril formation results in calcium influx across the plasma…”
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Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents by Moss, C. E., Marsh, W. J., Parker, H. E., Ogunnowo-Bada, E., Riches, C. H., Habib, A. M., Evans, M. L., Gribble, F. M., Reimann, F.

“…Aims/hypothesis Glucose-dependent insulinotropic polypeptide (GIP) is an enteroendocrine hormone that promotes storage of glucose and fat. Its secretion from…”
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PREPROGLUCAGON (PPG) NEURONS INNERVATE NEUROCHEMICALLY IDENTIFIED AUTONOMIC NEURONS IN THE MOUSE BRAINSTEM by LLEWELLYN-SMITH, I. J, GNANAMANICKAM, G. J. E, REIMANN, F, GRIBBLE, F. M, TRAPP, S

“…Preproglucagon (PPG) neurons produce glucagon-like peptide-1 (GLP-1) and occur primarily in the nucleus tractus solitarius (NTS). GLP-1 affects a variety of…”
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Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells by REIMANN, F, WILLIAMS, L, DA SILVA XAVIER, G, RUTTER, G. A, GRIBBLE, F. M

“…Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are secreted from enteroendocrine L cells in response to nutrient ingestion. As glutamine is an important…”
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ATP-sensitive K+ channels and insulin secretion : their role in health and disease by ASHCROFT, F. M, GRIBBLE, F. M

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Use of Ex Vivo Normothermic Perfusion for Quality Assessment of Discarded Human Donor Pancreases by Barlow, A. D., Hamed, M. O., Mallon, D. H., Brais, R. J., Gribble, F. M., Scott, M. A., Howat, W. J., Bradley, J. A., Bolton, E. M., Pettigrew, G. J., Hosgood, S. A., Nicholson, M. L., Saeb‐Parsy, K.

“…A significant number of pancreases procured for transplantation are deemed unsuitable due to concerns about graft quality and the associated risk of…”
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Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity by Worthington, J J, Reimann, F, Gribble, F M

“…The intestinal epithelium must balance efficient absorption of nutrients with partitioning commensals and pathogens from the bodies’ largest immune system. If…”
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Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line by Simpson, A. K, Ward, P. S, Wong, K. Y, Collord, G. J, Habib, A. M, Reimann, F, Gribble, F. M

“…Aims/hypothesis To investigate the pathways by which cyclic AMP (cAMP) stimulates glucagon-like peptide-1 (GLP-1) secretion, using the GLUTag enteroendocrine…”
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The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release by Ong, WK, Gribble, FM, Reimann, F, Lynch, MJ, Houslay, MD, Baillie, GS, Furman, BL, Pyne, NJ

“…Background and purpose:  Increases in intracellular cyclic AMP (cAMP) augment the release/secretion of glucagon‐like peptide‐1 (GLP‐1). As cAMP is hydrolysed…”
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Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion by da Silva Xavier, G., Farhan, H., Kim, H., Caxaria, S., Johnson, P., Hughes, S., Bugliani, M., Marselli, L., Marchetti, P., Birzele, F., Sun, G., Scharfmann, R., Rutter, J., Siniakowicz, K., Weir, G., Parker, H., Reimann, F., Gribble, F. M., Rutter, G. A.

“…Aims/hypothesis We assessed whether per-arnt-sim (PAS) domain-containing protein kinase (PASK) is involved in the regulation of glucagon secretion. Methods…”
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The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line by Gameiro, A., Reimann, F., Habib, A. M., O'Malley, D., Williams, L., Simpson, A. K., Gribble, F. M.

“…The incretin hormone, glucagon-like peptide-1 (GLP-1) is released from intestinal L-cells following food ingestion. Its secretion is triggered by a range of…”
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The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide by Gribble, Fiona M., Tucker, Stephen J., Ashcroft, Frances M.

“…The ATP‐sensitive K‐channel (K‐ATP channel) plays a key role in insulin secretion from pancreatic β‐cells. It is closed by glucose metabolism, which stimulates…”
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